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Superantigen-mediated differentiation of bovine monocytes into dendritic cells
Seo, K. S.,Park, J. Y.,Davis, W. C.,Fox, L. K.,McGuire, M. A.,Park, Y. H.,Bohach, G. A. Wiley (John WileySons) 2009 Journal of Leukocyte Biology Vol.85 No.4
<P>Although many effects of staphylococcal superantigens (SAg) on T cells are well established, less is known about their effects on APC. In this study, bovine PBMC were stimulated with a low dose of staphylococcal enterotoxin C1 (SEC1). The phenotype of adherent cells (Ac) derived from bovine PBMC cultured with SEC1 [SEC1-stimulated Ac (sAc)] for 192 h was CD14(-), CD68(-), CD163(-), dendritic cell (DC)-specific ICAM-3-grabbing nonintegrin(+), MHC class II (MHC II)(high), CD11a(low), CD11b(high), CD11c(high), and CD1b(high), suggesting these cells were dendritic cells (DC). SEC1 also induced transcription of the CXCL1, -2, and -3 family, CXCL6, CCL2, and CCL5 genes in sAc, which increased rapidly but returned to basal levels by 48 h. In contrast, increased transcription of CCL3, CCL8, and CXCL12, responsible for mononuclear cell migration and chronic inflammation, was sustained. In vitro cell migration assays showed vigorous migration of granulocytes, followed by migration of mononuclear cells. The autologous MLR showed that sAc induced a dose-dependent proliferation of CD4(+) T cells and an even stronger proliferation of CD8(+) T cells. This effect was inhibited or reduced by pretreatment with mAb to CD11b, MHC II, or MHC II plus CD18. These results indicate that stimulation of bovine PBMC by SAg induces differentiation of monocytes into DC.</P>
데이비스,Davis, G.H. 한국토양비료학회 1979 한국토양비료학회지 Vol.11 No.4
Pasture establishment techniques successfully employed in the alpine region of Korea are outlined. The subsequent management of the mixed grass/legume pasture to maintain a high producing sward is also described. Relevant overseas literature has been reviewed and related to the methods in use at the ROK/NZ Beef Farming Research and Demonstration Project in the alpine region of Kangweon-do.
Pain Fiber Anesthetic Reduces Brainstem Fos after Tooth Extraction
Badral, B.,Davies, A.J.,Kim, Y.H.,Ahn, J.S.,Hong, S.D.,Chung, G.,Kim, J.S.,Oh, S.B. SAGE Publications 2013 Journal of dental research Vol.92 No.11
<P>We recently demonstrated that pain-sensing neurons in the trigeminal system can be selectively anesthetized by co-application of QX-314 with the TRPV1 receptor agonist, capsaicin (QX cocktail). Here we examined whether this new anesthetic strategy can block the neuronal changes in the brainstem following molar tooth extraction in the rat. Adult male Sprague-Dawley rats received infiltration injection of anesthetic 10 min prior to lower molar tooth extraction. Neuronal activation was determined by immunohistochemistry for the proto-oncogene protein c-Fos in transverse sections of the trigeminal subnucleus caudalis (Sp5C). After tooth extraction, c-Fos-like immunoreactivity (Fos-LI) detected in the dorsomedial region of bilateral Sp5C was highest at 2 hrs (<I>p</I> < .01 <I>vs</I>. naïve ipsilateral) and declined to pre-injury levels by 8 hrs. Pre-administration of the QX cocktail significantly reduced to sham levels Fos-LI examined 2 hrs after tooth extraction; reduced Fos-LI was also observed with the conventional local anesthetic lidocaine. Pulpal anesthesia by infiltration injection was confirmed by inhibition of the jaw-opening reflex in response to electrical tooth pulp stimulation. Our results suggest that the QX cocktail anesthetic is effective in reducing neuronal activation following tooth extraction. Thus, a selective pain fiber ‘nociceptive anesthetic’ strategy may provide an effective local anesthetic option for dental patients in the clinic.</P>
고랭지의 무방풍벽 조건하에서 월동한 번식용육우의 생산능력
지 . 에치 . 데이비스 ( G . H . Davis ) 한국축산학회 1985 한국축산학회지 Vol.27 No.1
Comparisons were made between beef breeding cows outwintered and housed during two winters. At the same level of feeding housed cows gained 16.1-20.9 ㎏ more weight during winter than outwintered cows. However, when both groups grazed together on pasture during the following spring and summer the outwintered cows gained weight faster than the housed cows and reduced the weight difference to only 2.4-4.1 ㎏. There was no carry over effect on calf growth and it is concluded that totally enclosed shelter is unnecessary during winter for Hereford or Angus beef breeding cows in South Korea.
Smith, A.S.T.,Davis, J.,Lee, G.,Mack, D.L.,Kim, D.H. Elsevier Science Ltd ; Distributed by Virgin Maili 2016 DRUG DISCOVERY TODAY Vol.21 No.9
Engineered in vitro models using human cells, particularly patient-derived induced pluripotent stem cells (iPSCs), offer a potential solution to issues associated with the use of animals for studying disease pathology and drug efficacy. Given the prevalence of muscle diseases in human populations, an engineered tissue model of human skeletal muscle could provide a biologically accurate platform to study basic muscle physiology, disease progression, and drug efficacy and/or toxicity. Such platforms could be used as phenotypic drug screens to identify compounds capable of alleviating or reversing congenital myopathies, such as Duchene muscular dystrophy (DMD). Here, we review current skeletal muscle modeling technologies with a specific focus on efforts to generate biomimetic systems for investigating the pathophysiology of dystrophic muscle.
Ashley E. MacConnell,William Davis,Rebecca Burr,Andrew Schneider,Lara R Dugas,Cara Joyce,Dane H. Salazar,Nickolas G. Garbis 대한견주관절의학회 2023 대한견주관절의학회지 Vol.26 No.2
Background: Sleep quality, quantity, and efficiency have all been demonstrated to be adversely affected by rotator cuff pathology. Previous measures of assessing the impact of rotator cuff pathology on sleep have been largely subjective in nature. This study was undertaken to objectively analyze this relationship through the use of activity monitors. Methods: Patients with full-thickness rotator cuff tears at a single institution were prospectively enrolled between 2018 and 2020. Waist-worn accelerometers were provided for the patients to use each night for 14 days. Sleep efficiency was calculated using the ratio of the time spent sleeping to the total amount of time that was spent in bed. Retraction of the rotator cuff tear was classified using the Patte staging system. Results: This study included 36 patients: 18 with Patte stage 1 disease, 14 with Patte stage 2 disease, and 4 patients with Patte stage 3 disease. During the study, 25 participants wore the monitor on multiple nights, and ultimately their data was used for the analysis. No difference in the median sleep efficiency was appreciated amongst these groups (P>0.1), with each cohort of patients demonstrating a generally high sleep efficiency. Conclusions: The severity of retraction of the rotator cuff tear did not appear to correlate with changes in sleep efficiency for patients (P>0.1). These findings can better inform providers on how to counsel their patients who present with complaints of poor sleep in the setting of full-thickness rotator cuff tears.