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Effects of the NQO1 609C>T Polymorphism on Leukemia Susceptibility: Evidence from a Meta-analysis
Han, Fei-Fei,Guo, Chang-Long,Gong, Li-Li,Jin, Zhu,Liu, Li-Hong Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.9
A functional polymorphism in the NQO1 gene, featuring a 609C>T substitution,leading to proline to serine amino-acid and enzyme activity changes, has been implicated in cancer risk. However, individually published investigations showed inconclusive results, especially for leukemia. In this study, we therefore performed a meta-analysis of 21 publications with a total of 3,634 cases and 4,827controls, mainly for leukemia. We summarized the data on the association between the NQO1 609C>T polymorphism and risk of leukemia and performed subgroup analyses by ethnicity and leukemia type. We found that the variant TT homozygous genotype o was associated with a modestly increased risk of leukemia (TT versus CT/CC: OR=1.23, 95%CI=1.00-1.51, heterogeneity=0.76; $I^2$=0%). Following further stratified analyses, increased risk was only observed in subgroups of Caucasians. This meta-analysis suggests that the NQO1 609T allele is a high-penetrance risk factor for leukemia in Caucasians. The effect on leukemia may be modified by ethnicity and leukemia type, and the small sample sizes of the subgroup analyses suggest that further larger studies are needed.
Glacier Change in the Yigong Zangbo Basin, Tibetan Plateau, China
Chang-Qing Ke,Hoonyol Lee,Yan-Fei Han 대한원격탐사학회 2019 大韓遠隔探査學會誌 Vol.35 No.4
Distinguishing debris-covered glaciers from debris-free glaciers is difficult when using only optical remote sensing images to extract glacier boundaries. According to the features that the surface temperature of debriscovered glacier is lower than surrounding objects, and higher than clean glaciers, glacial changes in the Yigong Zangbo basin was analyzed on the basis of visible, near-infrared and thermal-infrared band images of Landsat TM and OLI/TIRS in the support of ancillary digital elevation model (DEM). The results indicated that glacier area gradually declined from 928.76 km2 in 1990 to 918.46 km2 in 2000 and 901.51 km2 in 2015. However, debriscovered glacier area showed a slight increase from 63.39 km2 in 1990 to 66.24 km2 in 2000 and 71.16 km2 in 2015. During 25 years, the glacier length became shorter continuously with terminus elevation rising up. The area of moraine lakes in 1990 was 1.43 km2, which increased to 1.98 km2 in 2000 and 3.41 km2 in 2015. In other words, the total area of the moraine lakes in 2015 is 2.38 times of that in 1990. This increase in moraine lake area could be the result of accelerated glacier melt and retreat, which is consistent with the significant warming trend in recent decades in the basin.
Chang, Fei,Park, Seo-Hun,Kim, Hakwon Korean Chemical Society 2008 Bulletin of the Korean Chemical Society Vol.29 No.7
Novel $CO_2$-soluble 8-hydroxyquinoline (8-HQ) chelating agents were synthesized and evaluated for solubility and metal ion extraction ability in supercritical $CO_2\;(Sc-CO_2)$. Among them, secondary amide-containing 8- HQ derivatives cannot be dispersed well into Sc-$CO_2$, but tertiary amide-containing derivatives can dissolve completely in Sc-$CO_2$ even at low CO2 pressures, perhaps owing to the predominant intermolecular interaction between the chelating agent and the $CO_2$ molecule. Based on 8-HQ chelating agent solubility data, we investigated the extraction of metal ions ($Co^{2+}$, $Cu^{2+}$, $Sr^{2+}$, $Cd^{2+}$, and $Zn^{2+}$) using two highly $CO_2$-soluble 8-HQ derivatives (4d, 4e) in Sc-$CO_2$. The extraction efficiency of tertiary amide-containing 8-HQ ligands, both fluorinated and non-fluorinated forms, was dramatically increased in the presence of diethyl amine (organic base). We suggest that diethyl amine could play an important synergistic role in the stronger metal binding ability of 8-HQ through an in situ deprotonation reaction in Sc-$CO_2$ medium.
An Extended Looped Functional Approach for Stability Analysis of T-S Fuzzy Impulsive Control Systems
Fei Chang,Chuandong Li 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.7
In this paper, the stability analysis of T-S fuzzy impulsive control systems is studied based on an extended looped functional approach. The extended functional is differentiable between two impulsive intervals. The value of the functional at tk+1 minus the value at t+k has been improved to be nonnegative rather than zero in traditional looped functional methods. With the extended bilateral looped functional, stability conditions for T-S fuzzy impulsive control systems with less conservative are obtained in the form of LMIs. The stability conditions under existing looped functional method are also given as a special case. Furthermore, the impulsive fuzzy controller is designed. Two numerical examples verify the feasibility of the proposed results.
Progressive collapse analysis of steel frame structure based on the energy principle
Chang Hong Chen,Yan Fei Zhu,Yao Yao,Ying Huang 국제구조공학회 2016 Steel and Composite Structures, An International J Vol.21 No.3
The progressive collapse potential of steel moment framed structures due to abrupt removal of a column is investigated based on the energy principle. Based on the changes of component's internal energy, this paper analyzes structural member's sensitivity to abrupt removal of a column to determine a sub-structure resisting progressive collapse. An energy-based structural damage index is defined to judge whether progressive collapse occurs in a structure. Then, a simplified beam damage model is proposed to analyze the energies absorbed and dissipated by structural beams at large deflections, and a simplified modified plastic hinges model is developed to consider catenary action in beams. In addition, the correlation between bending moment and axial force in a beam during the whole deformation development process is analyzed and modified, which shows good agreement with the experimental results.