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Larik, Fayaz Ali,Faisal, Muhammad,Saeed, Aamer,Channar, Pervaiz Ali,Korabecny, Jan,Jabeen, Farukh,Mahar, Ihsan Ali,Kazi, Mehar Ali,Abbas, Qamar,Murtaza, Ghulam,Khan, Gul Shahzada,Hassan, Mubashir,Seo, Academic Press 2019 Bioorganic chemistry Vol.86 No.-
<P><B>Abstract</B></P> <P>The increasing resistance of pathogens to common antibiotics, as well as the need to control urease activity to improve the yield of soil nitrogen fertilization in agricultural applications, has stimulated the development of novel classes of molecules that target urease as an enzyme. In this context, the newly developed compounds on the basis of 1-heptanoyl-3-arylthiourea family were evaluated for Jack bean urease enzyme inhibition activity to validate their role as potent inhibitors of this enzyme. 1-Heptanoyl-3-arylthioureas were obtained in excellent yield and characterized through spectral and elemental analysis. All the compounds displayed remarkable potency against urease inhibition as compared to thiourea standard. It was found that novel compounds fulfill the criteria of drug-likeness by obeying Lipinski’s rule of five. Particularly compound <B>4a</B> and <B>4c</B> can serve as lead molecules in 4D (drug designing discovery and development). Kinetic mechanism and molecular docking studies also carried out to delineate the mode of inhibition and binding affinity of the molecules.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A new family of 1-heptanoyl-3-arylthioureas (<B>4a-4j</B>) was synthesized in excellent yield. </LI> <LI> The synthesized 1-heptanoyl-3-arylthiourea family were evaluated for Jack bean urease enzyme inhibition activity. </LI> <LI> Particularly compound <B>4a</B> and <B>4c</B> can serve as lead molecules in 4D (drug designing discovery and development). </LI> <LI> Kinetic mechanism and molecular docking studies also carried out to delineate the mode of inhibition and binding affinity. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Improvement of mechanical properties of bio-concrete using Enterococcus faecalis and Bacillus cereus
Abdullah Faisal Alshalif,Mohd Irwan Juki,Norzila Othman,Adel Ali Al-Gheethi,Faisal Sheikh Khalid 대한환경공학회 2019 Environmental Engineering Research Vol.24 No.4
The present study aimed to investigate the potential of Enterococcus faecalis (E. faecalis) and Bacillus cereus (B. cereus) in improving the properties of bio-concrete. E. faecalis and B. cereus strains were obtained from fresh urine and an acid mire water at cell concentration of 1.16×1012 and 1.3×1012 cells mL-1, respectively. The bacterial strains were inoculated in a liquid medium into the concrete with 1, 3 and 5% as replacement of water cement ratio (w/c). The ability of E. faecalis and B. cereus cells to accumulate the calcite and the decrement of pores size within bio-concrete was confirmed by SEM and EDX analysis. The results revealed that E. faecalis exhibited high efficiency for increasing of compressive and splitting tensile strength than B. cereus (23 vs. 14.2%, and 13 vs. 8.5%, respectively). These findings indicated that E. faecalis is more applicable in the bio-concrete due to its ability to enhance strength development and reduce water penetration.
Toxic potential of some indigenous plant oils against the rice weevil, Sitophilus oryzae (Linnaeus)
Hafiz Azhar Ali KHAN,Waseem AKRAM,이수미,Taskeen AHMAD,Kamran MAQSOOD,Hassan Ali KHAN,Muhammad Waqas NAZIR,Muhammad Faisal JAVAID 한국곤충학회 2019 Entomological Research Vol.49 No.3
The present study was conducted to evaluate the toxic potential of five indigenous plant oils: black pepper (Piper nigrum), Chinese cinnamon (Cinnamomum cassia), garlic (Allium sativum), river red gum (Eucalyptus camaldulensis), and yellow oleander (Thevetia peruviana), against laboratory reared Sitophilus oryzae adults. The bioassays were done by the diet incorporation method with concentrations ranging from 50 ppm to 500 ppm. Based on lethal concentrations to kill 50% (LC50) of the subjected weevils, T. peruviana proved to be the most toxic having the lowest LC50 values, 414.58, 201.94, and 129.52 ppm, after 7, 14, and 21 days of exposure, respectively, followed by E. camaldulensis (475.51, 366.65, and 251.28 ppm, respectively). The rest of the plant oils also showed toxic potential, but these were less toxic compared with T. peruviana and E. camaldulensis. With respect to the time taken to cause 50% mortality (LT50) of the exposed weevils, T. peruviana had LT50 at 14.54 days followed by P. nigrum (22.09 days), E. camaldulensis (24.29 days), and C. cassia (28.71 days). Whereas, A. sativum took the longest time (44.47 days) to cause 50% mortality of the exposed weevils. In conclusion, the result revealed toxic potential of tested plant oils, and suggests further studies under simulated-field conditions should be included in the management plan for S. oryzae.
Explaining Growth in an Emerging Market
Ali F. Darrat i,Khaled Elkhal,Faisal B. Al-Khateeb 사람과세계경영학회 2010 Global Business and Finance Review Vol.15 No.1
We explore whether, and to what extent, financial deepening, human capital and information technology could explain the rapid economic growth that the United Arab Emirates (UAE) has experienced in recent years. We find compelling evidence that these factors, particularly human capital and information technology, are indispensable ingredients for promoting economic growth but only over the long-run. Consistent with the underlying theory, our results fail to support significant short-run growth gains from any of the growth factors. Together, these results imply that programs to invigorate the education system and the technological infrastructure in the UAE represent an effective growth strategy for the country, although such efforts must persist even in the absence of any quick growth benefits.
Capital Structure and Financial Performance: A Case of Saudi Petrochemical Industry
ALI, Anis,FAISAL, Shaha Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.7
The study investigates and measures the impact of capital structure, profitability and financial performance on the success of the business organization. Capital structure of the business organization refers to the proportion of external funds and internal funds, i.e., debt and equity. In Saudi Arabia, petrochemicals companies are working on equity, but financial performance reflects negative trend for the period 2004 to 2016. The research is based upon secondary data available on the websites of petrochemicals companies of Saudi Arabia. Financial Ratio variability analysis and Trend Indices of financial ratios (TI<sub>CBI</sub>) measure and compare the financial variability and sensitivity of financial ratios of the business organization. Correlation between Trend Indices (TI<sub>CBI</sub>) of independent variable and dependent variables are to be calculated to know the impact of changes in debt equity on other dependent variables. The results reveal the unexpected performance of petrochemicals companies due to under-utilization of the resources caused by low demand and lower prices of the products governed by some internal and external factors. The study finds that size, demand, cost of production, profitable streams of products, and low cost capital in external funds are the factors responsible for overall growth development of the petrochemicals industry of Saudi Arabia.
High participation in the Posyandu nutrition program improved children nutritional status
Faisal Anwar,Ali Khomsan,Dadang Sukandar,Hadi Riyadi,Eddy S. Mudjajanto 한국영양학회 2010 Nutrition Research and Practice Vol.4 No.3
The objective of this research was to analyze nutritional status and food consumption of children participating in the Posyandu nutrition program. A total sample of 300 children under five years had been drawn. Sample was divided into two categories namely high participation and low participation in the Posyandu nutrition program. The sample was selected from two sub districts of Cianjur District, West Java. The districts were areas with a high proportion of poor people and many of them take the benefits of Posyandu nutrition program conducted by the government. The participation of children (under five years old) in visiting Posyandus was relatively good, namely, 92.4% (for the high participation group). However, for the low participation group, the number of participating children was relatively low (28.3%). The average consumption of energy for children under five years old was still below the recommended dietary allowance < 80% of RDA, whereas the protein consumption was already above the RDA. The prevalence of underweight, stunting, and wasting among children were respectively 30.0%, 43.7%, and 12.3%. The activities at Posyandus had a positive impact on the nutritional status of children under five years olds, measured in terms of weight for age (W/A) and weight for height (W/H). The more frequent the visit to Posyandus, the better the nutritional statuses would be.
Comparison of Home Automation System Using IPV-4 and IPV-6 Based On Mitigate Reconnaissance Attacks
Ali, Muhammad Shujat,Siddiq, Imran,Faisal, Abdullah,Awan, Muhammad Zubair International Journal of Computer ScienceNetwork S 2022 International journal of computer science and netw Vol.22 No.2
This research is designed to help and offer hold up to complete the requirements of aged and disable in a home. The control approach and the tone approach are used to manage the house appliances. The major organize system implementation in technology of wireless to offer distant contact from a phone Internet Protocol connectivity for access and calculating strategy and appliance remotely. The planned system no need a committed server PC with value of parallel systems and offers a new communication-protocol to observe and control a house environment with more than just the switch functionality. To express the possibility and efficiency of this system, devices like as lights switches, power plugs, and motion-sensors have been included with the planned home control system and supply more security manage on the control with low electrical energy activate method. The rank of switches is corresponding in all this control system whereby all user interfaces indicate the real time existing status. This system planned to manage electrical-appliances and devices in house with reasonably low cost of design, user friendly interface, easily install and provide high security. Research community generally specified that the network "Reconnaissance Attacks" in IPv6 are usually impossible due to they will take huge challenge to carry out address scanning of 264 hosts in an IPv6 subnet."It being deployed of IPv6 shows that it definitely enhances security and undermines the probability". This research of the IPv6 addressing-strategies at present utilizes and planned a new strategy and move toward to "mitigate reconnaissance attacks".