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Subcellular Localization of Diacylglycerol-responsive Protein Kinase C Isoforms in HeLa Cells
Kazi, Julhash U.,Kim, Cho-Rong,Soh, Jae-Won Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.9
Subcellular localization of protein kinase often plays an important role in determining its activity and specificity. Protein kinase C (PKC), a family of multi-gene protein kinases has long been known to be translocated to the particular cellular compartments in response to DAG or its analog phorbol esters. We used C-terminal green fluorescent protein (GFP) fusion proteins of PKC isoforms to visualize the subcellular distribution of individual PKC isoforms. Intracellular localization of PKC-GFP proteins was monitored by fluorescence microscopy after transient transfection of PKC-GFP expression vectors in the HeLa cells. In unstimulated HeLa cells, all PKC isoforms were found to be distributed throughout the cytoplasm with a few exceptions. PKC$\theta$ was mostly localized to the Golgi, and PKC$\gamma$, PKC$\delta$ and PKC$\eta$ showed cytoplasmic distribution with Golgi localization. DAG analog TPA induced translocation of PKC-GFP to the plasma membrane. PKC$\alpha$, PKC$\eta$ and PKC$\theta$ were also localized to the Golgi in response to TPA. Only PKC$\delta$ was found to be associated with the nuclear membrane after transient TPA treatment. These results suggest that specific PKC isoforms are translocated to different intracellular sites and exhibit distinct biological effects.
Kazi Mohammad Masum,Md. Mehedi Hasan 강원대학교 산림과학연구소 2020 Journal of Forest Science Vol.36 No.3
Satchari National Park is one of the most biodiverse forest in Bangladesh and home of many endangered flora and fauna. 206 tons of CO2 per hectare is sequestrated in this national park every year which helps to mitigate climate issues. As people living near the area are dependent on this forest, degradation has become a regular phenomenon destroying the forest biodiversity by altering its forest cover. So, it is important to map land cover quickly and accurately for the sustainable management of Satchari National Park. The main objective of this study was to obtain information on land cover change using remote sensing data. Combination of unsupervised NDVI classification and supervised classification using maximum likelihood is followed in this study to find out land cover map. The analysis showed that the land cover is gradually converting from one land use type to another. Dense forest becoming degraded forest or bare land. Although it was slowed down by the establishment of ‘National Park’ on the study site, forecasting shows that it is not enough to mitigate forest degradation. Legal steps and proper management strategies should be taken to mitigate causes of degradation such as illegal felling.
Ecotourism Carrying Capacity and the Potentiality of the Safari Park of Bangladesh
Kazi Mohammad Masum,Abdullah Al Mamun,Zahed Mohammad Malekur Rahman,Md. Motlubur Rahman,Md. Shah Newaz,Mohammad Redowan 강원대학교 산림과학연구소 2013 Journal of Forest Science Vol.29 No.4
The study was undertaken to assess the tourist’s carrying capacity and to explore ecotourism potential of Bangabandhu Sheikh Mujib Safari Park, the only safari park of Bangladesh. Carrying capacity was assessed both from physical and social aspect. On the other hand, 250 visitors were interviewed with semi structured questionnaire for ecotourism prospect evaluation along with some secondary data. The total daily-allowed visit was 17,300 with rotation coefficient of 3.46. Maximum daily average numbers of tourists were relatively below the physical carrying capacity of the Park (5,000). The social carrying capacity was 4.38 persons per day. As there are different categories of visitors, their choice of encounters and number of expected encounters also varied. Each year, the total tourist’s number varied significantly (p≤0.05). That proved the safari park had immense tourist prospect. 85 percent visitors were from lower and middle class family as entrance fees and other fees inside were very cheap in relation to other private amusement place. The ecological perspective of the park will remain unaltered if the carrying capacities of the area are followed with sustainability. Therefore, it is the proper time for taking appropriate decision.
Kazi Ahsan Habib,Amit Kumer Neogi,오진아,이윤호,김충곤 한국해양과학기술원 2019 Ocean science journal Vol.54 No.1
The new puffer fish species Chelonodontops bengalensis (Pisces: Tetraodontidae) is described from two specimens collected on the southwest coast of the Bay of Bengal, Bangladesh. C. bengalensis is closely related to C. patoca (Hamilton, 1822), both species being large puffers with a peculiar, disc-shaped exposed nasal organ. The new species however differs from C. patoca with respect to dorsal rays (12 vs 10), anal rays (10 vs 8), pectoral rays (19 vs 15–16) and gill rakers (8 vs 7). C. bengalensis has spinules on its lateral sides but not on the caudal peduncle (vs. a patch of spinules on the back from behind the interorbital nearly to the dorsal fin and another on the throat and abdomen but absent on the lateral sides in C. patoca). Both the DNA barcode region of the mitochondrial COI gene and 16S rRNA gene region of C. bengalensis showed a clear monophyletic clade that distinguishes it as a separate species in the phylogenetic tree from other closely related puffer fish species. The COI barcode region shows a genetic divergence of 6 to 7.6% between C. bengalensis and C. patoca reported in GenBank from different parts of Asia.
Induction of the Nuclear Proto-Oncogene c-fos by the Phorbol Ester TPA and c-H-Ras.
Kazi, Julhash U,Soh, Jae-Won Korean Society for Molecular Biology 2008 Molecules and cells Vol.26 No.5
<P>TPA is known to cooperate with an activated Ras oncogene in the transformation of rodent fibroblasts, but the biochemical mechanisms responsible for this effect have not been established. In the present study we used c-fos promoter-luciferase constructs as reporters, in transient transfection assays, in NIH3T3 cells to assess the mechanism of this cooperation. We found a marked synergistic interaction between TPA and a transfected v-Ha-ras oncogene in the activation of c-fos promoter and SRE. SRE has binding sites for TCF and SRF. A dominant-negative Ras (ras-N17) inhibited the TPA-Ras synergy by blocking the PKC-MAPK-TCF pathway. Dominant-negative RhoA and Rac1 (but not Cdc42Hs) inhibited the TPA-Ras synergy by blocking the Ras-Rho-SRF signaling pathway. Constitutively active PKCalpha and PKCepsilon showed synergy with v-Ras. These results suggest that the activation of two distinct pathways such as Ras-Raf-ERK-TCF pathway and Rho-SRF pathway are responsible for the induction of c-fos by TPA and Ras in mitogenic signaling pathways.</P>
Analysis of LinkedIn Jobs for Finding High Demand Job Trends Using Text Processing Techniques
Kazi, Abdul Karim,Farooq, Muhammad Umer,Fatima, Zainab,Hina, Saman,Abid, Hasan International Journal of Computer ScienceNetwork S 2022 International journal of computer science and netw Vol.22 No.10
LinkedIn is one of the most job hunting and career-growing applications in the world. There are a lot of opportunities and jobs available on LinkedIn. According to statistics, LinkedIn has 738M+ members. 14M+ open jobs on LinkedIn and 55M+ Companies listed on this mega-connected application. A lot of vacancies are available daily. LinkedIn data has been used for the research work carried out in this paper. This in turn can significantly tackle the challenges faced by LinkedIn and other job posting applications to improve the levels of jobs available in the industry. This research introduces Text Processing in natural language processing on datasets of LinkedIn which aims to find out the jobs that appear most in a month or/and year. Therefore, the large data became renewed into the required or needful source. This study thus uses Multinomial Naïve Bayes and Linear Support Vector Machine learning algorithms for text classification and developed a trained multilingual dataset. The results indicate the most needed job vacancies in any field. This will help students, job seekers, and entrepreneurs with their career decisions