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        The Unresolved Case of Sacral Chordoma: From Misdiagnosis to Challenging Surgery and Medical Therapy Resistance

        Fabio Garofalo,Dimitrios Christoforidis,Pietro G. di Summa,Béatrice Gay,Stéphane Cherix,Wassim Raffoul,Nicolas Demartines,Maurice Matter 대한대장항문학회 2014 Annals of Coloproctolgy Vol.30 No.3

        Purpose: A sacral chordoma is a rare, slow-growing, primary bone tumor, arising from embryonic notochordal remnants. Radical surgery is the only hope for cure. The aim of our present study is to analyse our experience with the challenging treatment of this rare tumor, to review current treatment modalities and to assess the outcome based on R status. Methods: Eight patients were treated in our institution between 2001 and 2011. All patients were discussed by a multidisciplinary tumor board, and an en bloc surgical resection by posterior perineal access only or by combined anterior/posterior accesses was planned based on tumor extension. Results: Seven patients underwent radical surgery, and one was treated by using local cryotherapy alone due to low performance status. Three misdiagnosed patients had primary surgery at another hospital with R1 margins. Reresection margins in our institution were R1 in two and R0 in one, and all three recurred. Four patients were primarily operated on at our institution and had en bloc surgery with R0 resection margins. One had local recurrence after 18 months. The overall morbidity rate was 86% (6/7 patients) and was mostly related to the perineal wound. Overall, 3 out of 7 resected patients were disease-free at a median follow-up of 2.9 years (range, 1.6–8.0 years). Conclusion: Our experience confirms the importance of early correct diagnosis and of an R0 resection for a sacral chordoma invading pelvic structures. It is a rare disease that requires a challenging multidisciplinary treatment, which should ideally be performed in a tertiary referral center.

      • KCI등재

        Monitoring of the exotic fly Drosophila suzukii in stone, pome and soft fruit orchards in NWItaly

        Fabio Mazzetto,Marco G. Pansa,Barbara L. Ingegno,Luciana Tavella,Alberto Alma 한국응용곤충학회 2015 Journal of Asia-Pacific Entomology Vol.18 No.2

        After its introduction in Europe, Drosophila suzukii Matsumura (Diptera: Drosophilidae), an invasive pest native to South-East Asia, has rapidly spread into many European countries, including Italy, causing several economic losses on stone fruits and berries. Therefore, monitoring of fly adults and fruit damage was carried out in stone, pome and soft fruit orchards in two areas in NW Italy in 2011–2012. In 2012, different types of vinegars and traps [apple cider vinegar (ACV), mixture of wine vinegar and ACV, rice vinegar in transparent traps; ACV in red traps] were also used in the field; moreover, the responses of females to these vinegars were evaluated in the laboratory through a two-choice olfactometer. In the two-year field surveys, adults of D. suzukii were trapped in all orchards. In both years, after few specimens were caught in early spring, adults were no longer found until June. The captures increased in late summer, reaching higher peaks inOctober and November. In winter, the population decreased severely, but a few adults were still caught. At harvest, no damage was found on stone and pome fruits. Instead, severe yield losses occurred on berries, especially on later cultivars. In the field, the numbers of adults sampled by the tested vinegars fluctuated highly during the season, but significant differenceswere found only between red traps and the other ones. In the laboratory, ACVwas the most attractive substance for fly females in the two-choice olfactometer.

      • KCI등재후보

        Monitoring a steel building using GPS sensors

        Fabio Casciati,Clemente Fuggini 국제구조공학회 2011 Smart Structures and Systems, An International Jou Vol.7 No.5

        To assess the performance of a structure requires the measurement of global and relative displacements at critical points across the structure. They should be obtained in real time and in all weather condition. A Global Navigation Satellite System (GNSS) could satisfy the last two requirements. The American Global Position System (GPS) provides long term acquisitions with sampling rates sufficient to track the displacement of long period structures. The accuracy is of the order of sub-centimetres. The steel building which hosts the authors’ laboratory is the reference case-study within this paper. First a comparison of data collected by GPS sensor units with data recorded by tri-axial accelerometers is carried out when dynamic vibrations are induced in the structure by movements of the internal bridge-crane. The elaborations from the GPS position readings are then compared with the results obtained by a Finite Element (FE) numerical simulation. The purposes are: i) to realize a refinement of the structural parameters which characterize the building and ii) to outline a suitable way for processing GPS data toward structural monitoring.

      • KCI등재

        Sensor placement driven by a model order reduction (MOR) reasoning

        Fabio Casciati,Lucia Faravelli 국제구조공학회 2014 Smart Structures and Systems, An International Jou Vol.13 No.3

        Given a body undergoing a stress-strain status as consequence of external excitations, sensors can be deployed on the accessible lateral surface of the body. The sensor readings are regarded as input of a numerical model of reduced order (i.e., the number of sensors is lower than the number of the state variables the full model would require). The goal is to locate the sensors in such a way to minimize the deviations from the response of the true (full) model. One adopts either accelerometers as sensors or devices reading relative displacements. Two applications are studied: a plane frame is first investigated; the focus is eventually on a 3D body.

      • KCI등재후보

        Variability in mechanical properties and microstructure characterization of CuAlBe shape memory alloys for vibration mitigation

        Fabio Casciati,Casper van der Eijk 국제구조공학회 2008 Smart Structures and Systems, An International Jou Vol.4 No.2

        Shape memory alloys (SMA) have been emphasized, studied and understood in the controlled world of the laboratory. Any attempt to implement one of these alloys in engineered products requires a jump from the controlled world of the laboratory to the actual environment of the application. The first step is to move from single grain specimens to multigrain samples. One works with a material for which any stock is different from that previously available. This paper reviews the milestones in the familiarization process the authors had to overcome during their cooperation within a project funded by the European Union. The main items cover transformation temperatures, thermal treatment and properties understanding.

      • KCI등재

        Control of the along-wind response of steel framed buildings by using viscoelastic or friction dampers

        Fabio Mazza,Alfonso Vulcano 한국풍공학회 2007 Wind and Structures, An International Journal (WAS Vol.10 No.3

        The insertion of steel braces has become a common technique to limit the deformability of steel framed buildings subjected to wind loads. However, when this technique is inadequate to keep floor accelerations within acceptable levels of human comfort, dampers placed in series with the steel braces can be adopted. To check the effectiveness of braces equipped with viscoelastic (VEDs) or friction dampers (FRDs), a numerical investigation is carried out focusing attention on a three-bay fifteen-storey steel framed building with K-braces. More precisely, three alternative structural solutions are examined for the purpose of controlling wind-induced vibrations: the insertion of additional diagonal braces; the insertion of additional diagonal braces equipped with dampers; the insertion of both additional diagonal braces and dampers supported by the existing K-braces. Additional braces and dampers are designed according to a simplified procedure based on a proportional stiffness criterion. A dynamic analysis is carried out in the time domain using a step-by-step initial-stress-like iterative procedure. Along-wind loads are considered at each storey assuming the time histories of the wind velocity, for a return period Tr=5 years, according to an equivalent wind spectrum technique. The behaviour of the structural members, except dampers, is assumed linear elastic. A VED and an FRD are idealized by a six-element generalized model and a bilinear (rigid-plastic) model, respectively. The results show that the structure with damped additional braces can be considered, among those examined, the most effective to control vibrations due to wind, particularly the floor accelerations. Moreover, once the stiffness of the additional braces is selected, the VEDs are slightly more efficient than the FRDs, because they, unlike the FRDs, dissipate energy also for small amplitude vibrations.

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