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Blended Learning Approaches to Enhance Gender Mainstreaming
Claudia Wiepcke,Ewald Mittelstaedt,Andreas Liening 숙명여자대학교 아시아여성연구원 2008 Asian Women Vol.24 No.4
At the German labour market gender inequalities exist with respect to occupation. In order to counteract these inequalities, it is important to establish a policy of gender mainstreaming also in the area of education and to orient training measures in a gender-sensitive way. But how? The authors introduce the blended learning concept of the further education measure E-Office Managementand show that the consideration of female learning characteristics is possible when developing training measures. The evaluation of E-Office Management illustrates that a gender-sensitive further education measure can contribute to the enhancement of gender mainstreaming. On the basis of the described aspects of blended learning scenarios as well as due to the evaluation results, a set of standard rules for gender-sensitive, computer-assisted learning concepts has been formulated.
Root flow characteristics and 3D effects of an isolated wind turbine rotor
Galih Bangga,Thorsten Lutz,Ewald Krämer 대한기계학회 2017 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.31 No.8
The present study evaluates the 3D flow occurring in the inboard area of an isolated rotor blade operating in stalled conditions. The delayed detached-eddy simulation approach is applied, and a high-order weighted essentially non-oscillatory scheme is used for flux computation. The load data obtained from available literature are used to validate the numerical computations, and a good agreement is obtained. Three different velocity components, namely, axial, tangential, and radial, are evaluated. An accelerated nozzle flow effect is observed in the root area, generating a distinct root flow vortex that travels downstream in a helical manner. Furthermore, a strong radial flow is observed within the separated flow area that causes 3D effects; this radial flow is strong only in the blade inboard area with a chord to radius ratio (c/r) that is larger than 0.1. Consequently, the 3D lift coefficient in the blade inboard area is remarkably larger compared with the corresponding 2D condition.
Ultrafast Structural Dynamics of the Photocleavage of Protein Hybrid Nanoparticles
Ibrahimkutty, Shyjumon,Kim, Jangbae,Cammarata, Marco,Ewald, Friederike,Choi, Jungkweon,Ihee, Hyotcherl,Plech, Anton American Chemical Society 2011 ACS NANO Vol.5 No.5
<P>Protein-coated gold nanoparticles in suspension are excited by intense laser pulses to mimic the light-induced effect on biomolecules that occur in photothermal laser therapy with nanoparticles as photosensitizer. Ultrafast X-ray scattering employed to access the nanoscale structural modifications of the protein–nanoparticle hybrid reveals that the protein shell is expelled as a whole without denaturation at a laser fluence that coincides with the bubble formation threshold. In this ultrafast heating mediated by the nanoparticles, time-resolved scattering data show that proteins are not denatured in terms of secondary structure even at much higher temperatures than the static thermal denaturation temperature, probably because time is too short for the proteins to unfold and the temperature stimulus has vanished before this motion sets in. Consequently the laser pulse length has a strong influence on whether the end result is the ligand detachment (for example drug delivery) or biomaterial degradation.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2011/ancac3.2011.5.issue-5/nn200120e/production/images/medium/nn-2011-00120e_0007.eps'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn200120e'>ACS Electronic Supporting Info</A></P>
Is percutaneous destruction of a solitary liver colorectal metastasis as effective as a resection?
Ugo Marchese,Heloise Seux,Jonathan Garnier,Jacques Ewald,Gilles Piana,Bernard Lelong,Cecile De Chaisemartin,Helene Meillat,Jean-Robert Delpero,Olivier Turrini 한국간담췌외과학회 2021 Annals of hepato-biliary-pancreatic surgery Vol.25 No.2
Backgrounds/Aims: Surgical resection remains the gold standard in the treatment of colorectal liver metastasis. However, when a patient presents with a deep solitary colorectal liver metastasis (S-CLM), the balance between the hepatic volume sacrificed and the S-CLM volume is sometimes clearly unappropriated. Thus, alternatives to surgery, such as operative and percutaneous radiofrequency ablation (RFA) and microwave ablation (MWA), have been developed. This study aimed to identify the prognostic factors affecting survival of patients with S-CLM who undergo curative-intent liver resection or local destruction (RFA or MWA). Methods: We retrospectively identified 211 patients with synchronous or metachronous S-CLM who underwent either surgical resection (n=182) or local destruction (RFA or MWA; n=29) according to the S-CLM size, location, and surrounding Glissonian structures. Results: Patients who underwent RFA or MWA had S-CLM of a smaller size than those who underwent resection (mean 19.7 vs. 37.3 mm, p<.01). The 1-, 3-, and 5-year overall survival (OS) rates were 97.4%, 84.9%, and 74.9%, respectively. The 1-, 3-, and 5-year disease-free survival (DFS) rates were 77.9%, 47%, and 38.9%, respectively. S-CLM located in the left liver (p=.04), S-CLM KRAS mutation (p<.01), and extra-hepatic recurrence (p<.01) were identified as independent poor risk factors for overall survival (OS); the OS and DFS were comparable in patients with surgical procedure or percutaneous MWA. Conclusions: In eligible S-CLM cases, percutaneous MWA seems to be as oncologically efficient as surgical resection and should be include in the decision-tree for treatment strategies.
Galih Bangga,Pascal Weihing,Thorsten Lutz,Ewald Krämer 대한기계학회 2017 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.31 No.5
The present study focuses on the impact of grid for accurate prediction of the MEXICO rotor under stalled conditions. Two different blade mesh topologies, O and C-H meshes, and two different grid resolutions are tested for several time step sizes. The simulations are carried out using Delayed detached-eddy simulation (DDES) with two eddy viscosity RANS turbulence models, namely SpalartAllmaras (SA) and Menter Shear stress transport (SST) k-ω. A high order spatial discretization, WENO (Weighted essentially nonoscillatory) scheme, is used in these computations. The results are validated against measurement data with regards to the sectional loads and the chordwise pressure distributions. The C-H mesh topology is observed to give the best results employing the SST k-ω turbulence model, but the computational cost is more expensive as the grid contains a wake block that increases the number of cells.
Leakage of fluid around endotracheal tube cuffs: a cadaver study
Falk Birkenfeld,Ralph Lucius,Kristian Ewald 대한마취통증의학회 2013 Korean Journal of Anesthesiology Vol.65 No.5
Background: The aim of the study was to evaluate the leakage of liquid past the cuffs of tracheal tubes in fresh frozen human heads. Methods: Six truncated fresh frozen heads were used and intubated with 8.0 mm endotracheal tubes. The intracuff pressures tested were 30 and 100 cmH2O. Subsequently, 20 ml of each of two oral antiseptic rinses (0.2% chlorhexidine and octenidine [octenidolⓇ, Schülke & Mayr GmbH, Norderstedt, Germany]) was applied for thirty seconds in the mouth. During the trial, leakage of the cuffs was examined. Results: The sealing between the tracheal cuff and tracheal wall was leakage-proof for all tested intracuff pressures and all tested antiseptic rinses. However, approximately 5.6 ml and 1.8 ml leaked into the esophagus and remained as a cuff-puddle, respectively. Conclusions: The sealing between an endotracheal tube cuff with an intracuff pressure of 30 cmH2O and the tracheal wall is leakage-proof during oral care with antiseptic rinsing. An increase of intracuff pressure to 100 cmH2O does not appear to be required.