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        Association of Fluorodeoxyglucose Positron Emission Tomography Radiomics Features with Clinicopathological Factors and Prognosis in Lung Squamous Cell Cancer

        Mustafa Erol 대한핵의학회 2022 핵의학 분자영상 Vol.56 No.6

        Aim To evaluate the role of fluorine-18 fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography(PET/CT) radiomics features (RFs) for predicting clinicopathological factors (CPFs) and prognosis in patients with resectedlung squamous cell cancer (LSCC). Material and Methods Patients with early-stage (stage I–III) LSCC who underwent 18F-FDG PET/CT before surgical resectionbetween August 2012 and February 2020 were analyzed. Patients who received neoadjuvant chemotherapy or radiotherapywere excluded from the study. The maximum standard uptake value (SUVmax) and RFs were extracted from PETimages for primary tumors. The diagnostic performances of PET parameters in groups of tumor differentiation, stage, andmediastinal lymph node metastasis (MLNM) status were evaluated. The study endpoints were overall survival (OS) andprogression-free survival (PFS). Univariate and multivariate analyses were performed with RFs, SUVmax, and CPFs to findindependent predictors of PFS and OS. Results A total of 77 patients (5 female, 72 male) were included in the study. SUVmax and GLCM entropy were independentlyassociated with tumor differentiation. The only parameter with significant diagnostic performance for MLNM wasGLZLM-SLZGE. Tumor diameter and NGLDM busyness were independently associated with the stage. MLNM and tumordifferentiation were found to be independent predictors of PFS. NGLDM contrast and MLNM were independently associatedwith OS. Conclusion Using radiomic features in addition to CPFs to predict disease recurrence and shorter overall survival can guideprecision medicine in patients with LSCC.

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      • SCOPUSKCI등재
      • KCI등재

        Acquired noncaustic esophageal strictures in children

        Sag, Elif,Bahadir, Aysenur,Imamoglu, Mustafa,Sag, Sefa,Reis, Gokce Pinar,Erduran, Erol,Cakir, Murat The Korean Pediatric Society 2020 Clinical and Experimental Pediatrics (CEP) Vol.63 No.11

        Background: Esophageal stricture (ES) is an uncommon clinic entity in pediatrics that may be congenital or acquired in childhood. Acquired noncaustic ES is very rare, and clinical features of affected patients are unknown. Purpose: We aimed to evaluate the clinical findings, and outcomes of patients with acquired noncaustic ES to aid physicians in the early referral of patients to gastroenterologists. Methods: The medical data of patients with acquired noncaustic ES who were followed in our gastroenterology clinic between January 2009 and December 2019 were reviewed. Results: Acquired noncaustic ES was found in 12 of the 4,950 patients (0.24%) who underwent endoscopy during the study period. The main symptoms were dysphagia (58.3%), vomiting (33.3%), and chronic anemia (8.3%). Chronic malnutrition and underweight were found in 66.6% of the patients. The most common etiological factors were radiotherapy, peptic reflux, and achalasia (16.6%, each), while chemotherapy, squamous-cell carcinoma (SC) of the esophagus, eosinophilic esophagitis (EoE), esophageal web, epidermolysis bullosa, and esophageal diverticulum (8.2%, each) were the other etiological factors. Patients with EoE underwent endoscopic bougie dilation in addition to steroid use and elimination diet. Patients with epidermolysis bullosa and esophageal web underwent bougie dilation. Patients with peptic reflux-related ES were initially put on antireflux therapy, but during follow-up, one patient required esophageal replacement with colonic interposition. Patients with radiotherapy-related ES recovered with medical therapy. The patient with initially underwent surgical gastrostomy and tumoral mass excision. The patient then received chemotherapy and radiotherapy and underwent jejunal interposition. Patients with achalasia underwent surgical esophagomyotomy. Conclusion: The presence of solid dysphagia, malnutrition, and an associated disease may alert physicians to the presence of ES.

      • SCIESCOPUSKCI등재

        Effects of Boron Supplementation to Diets Deficient in Calcium and Phosphorus on Performance with Some Serum, Bone and Fecal Characteristics of Broiler Chickens

        Bozkurt, Mehmet,Kucukyilmaz, Kamil,Catli, Abdullah Ugur,Cinar, Mustafa,Cabuk, Metin,Bintas, Erol Asian Australasian Association of Animal Productio 2012 Animal Bioscience Vol.25 No.2

        Three levels of boron (0, 30, 60 ppm) were supplemented in practical corn-soybean based starter and grower diets, containing either adequate or inadequate Ca or P. A total of 1,800, 1-day-old sexed broiler chicks were assigned to six dietary treatments and fed with the experimental diets for 42 days. Boron improved the overall feed conversion ratio, but increased body weight only at 21 days of age (p<0.01). Boron decreased feed intake in the case of feeding on a diet deficient in Ca and P, and tended to increase feed intake when birds received a diet adequate in Ca and P, signifying significant boron by Ca-P interaction (p<0.01). Mortality was not influenced by boron (p>0.05). Dietary Ca and P deprivation reduced body weight and feed consumption significantly, but did not influence the feed conversion ratio and mortality (p>0.05). Serum Ca level, ALP and ALT activities were not influenced either by dietary Ca and P deficiency or boron supplementation. Serum P content increased with respect to boron at 30 ppm. Bone breakage strength was not affected by dietary variables. Tibia ash, Ca and P were increased in response to the supplementation diet with 30 ppm boron, whereas 60 ppm showed no effect in most cases. Accordingly, the dietary boron supplementation of 30 ppm significantly decreased fecal Ca and P excretion, while there was a numerical decline in the 60 ppm boron as compared to the 0 ppm boron group. Data presented herein indicated that boron, either at the 30 ppm or 60 ppm supplementation level, was effective in conversion of feed to body weight, whereas only boron at 30 ppm contributed to the mineralization of bone thereby augmenting more Ca and P while excreting less through faeces.

      • KCI등재

        ZnO nanostructures for photocatalytic degradation of methylene blue: effect of different anodization parameters

        Oksuz Ahmet Emrecan,Yurddaskal Metin,Kartal Ugur,Dikici Tuncay,Erol Mustafa 한국세라믹학회 2022 한국세라믹학회지 Vol.59 No.6

        In this paper, the photocatalytic activity of ZnO nanostructures formed by anodization method with diff erent parameters was investigated. The synthesis of ZnO nanostructures with diff erent morphology by varying anodic oxidation parameters containing electrolytes, molarity, voltage, and duration was analyzed. ZnO nanostructures were prepared through diff erent parameters consisting of six samples. The produced ZnO nanostructures were investigated by using X-ray diff raction, scan- ning electron microscopy, diff use refl ectance spectroscopy, and UV–Vis spectrophotometer. It was found that the morphology of ZnO structures was formed as nanorods, needle-like, fl ower-like, heterogeneous, and homogeneous of mixed structures. ZnO nanostructures were identified by matching X-Ray diffraction peaks due to the international center for diffraction data database. Experiments on photocatalytic degradation of methylene blue demonstrated that the photocatalytic activity of ZnO samples. The best photocatalytic performance was observed by the sample anodized for an hour in 0.05 M of KHCO 3 electrolytes with 40 V electrical potential. It was observed that the removal of methylene blue increased 3 times (photocatalytic degradation efficiency ~ 31% for methylene blue vs ~ 90% by the best sample) thanks to the obtained ZnO nanostructured photocatalysts. The results showed that an increment of the voltage has a significant effect on the photocatalytic activity of ZnO while keeping other parameters including molarity, time, and electrolyte type constant.

      • SCIESCOPUSKCI등재

        Effects of Rearing Systems on Performance, Egg Characteristics and Immune Response in Two Layer Hen Genotype

        Kucukyilmaz, Kamil,Bozkurt, Mehmet,Herken, Emine Nur,Cinar, Mustafa,Catli, Abdullah Ugur,Bintas, Erol,Coven, Fethiye Asian Australasian Association of Animal Productio 2012 Animal Bioscience Vol.25 No.4

        White (Lohmann LSL) and Brown (ATAK-S) laying hens, were reared under organic and conventional cage rearing systems, and the effects of the rearing system on performance parameters, egg production, egg characteristics, and immune response were investigated. For this purpose, a total of 832 laying hens of two commercial hybrids, i.e., 416 white (Lohmann LSL) and 416 Brown (ATAK-S) layers, were used. The experiment lasted between 23 and 70 wk of age. In this study, the white layers yielded more eggs as compared to the brown layers in both organic and conventional production systems. Egg weight exhibited a similar pattern to that of laying performance. However, the total hen-housed egg number for the white birds in the organic system was fewer than that of white birds in the conventional cage facility; conversely, a contradictory tendency was observed for the brown birds. Livability of the white layers in the organic system was remarkably lower (14%) than that of the brown line, whereas the white line survived better (3.42%) than their brown counterparts in conventional cages. The feed conversion ratio of the white hens was markedly inferior in the organic system as compared to that of the white hens in the conventional system, whereas relatively lower deterioration was reported in brown layers when reared in an organic system. The organic production system increased egg albumen height and the Haugh unit in eggs of the brown layers. The yolk color score of organic eggs was lower than that of conventional eggs for both brown and white hens. The egg yolk ratio of eggs from white layers was found to be higher in organic eggs as compared to those obtained in the conventional system. All organic eggs had heavier shells than those produced in the conventional system. Eggs from brown layers had more protein content than eggs from white layers. Neither housing systems nor genotype influenced egg yolk cholesterol concentration. When compared to conventional eggs, n-3 fatty acid content was lower in organic eggs, and the n-6:n-3 ratio was higher in organic eggs. In conclusion, two hen genotypes showed different responses in terms of performance and egg quality to two different rearing systems. A commercial white strain produced more eggs with higher egg quality as compared to a native brown strain. The brown strain was found to have adapted well to organic production conditions when survival and total egg number was taken into consideration.

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