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Dinneswara Reddy, Guda,Park, Sae-Jin,Cho, Hyeon Mo,Kim, Tack-Joong,Lee, Myong Euy American Chemical Society 2012 Journal of medicinal chemistry Vol.55 No.14
<P>A new class of sila-substituted 1,3,4-oxadiazoles was synthesized and evaluated for antiallergic activity using RBL-2H3 as the in vitro model and the in vivo anaphylactic mouse model. We observed that compound 5c effectively suppressed DNP-HSA-induced mast cell degranulation, compared to carbon analogue 9, and also suppressed the expression of TNF-α mRNA and Akt phosphorylation in antigen-stimulated RBL-2H3 cells. We also studied the effect of 5c in an in vivo passive cutaneous anaphylaxis (PCA) mouse model. The suppression by 5c was more effective than that by diphenylhydramine (DPH), a typical anti-histamine drug.</P>
Mallikarjuna, K.,Bathula, Chinna,Dinneswara Reddy, G.,Shrestha, Nabeen K.,Kim, Haekyoung,Noh, Yong-Young Elsevier 2019 International journal of biological macromolecules Vol.126 No.-
<P><B>Abstract</B></P> <P>Currently, metallic nanoparticles possessing versatile heterogeneous catalytic functionality such as in hydrogenation, water splitting, hydrogen production and CO<SUB>2</SUB> reduction for global pollution remediation have been paid great attentions due to their high chemical stability, superior activity and unique electrical and optical properties. However, the gradual degradation of their catalytic activity on multiple usage limits the monometallic nanoparticles to industrial applications. Herein, we fabricated the highly porous fenugreek polysaccharide assisted green synthesis of AuPd nanostructures for heterogeneous catalytic hydrogenation of the industrial usable highly toxic 4-nitrophenol to the medicinally useful 4-aminophenol. The aqueous method developed in the present work is environmentally friendly, simple and low-cost procedure. The fabricated bimetallic porous AuPd nanostructures characterized using SEM, TEM, UV–Vis, XRD, XPS and FTIR analysis. The catalytic activity of the synthesized nanostructures was studied for the heterogeneous hydrogenation of 4-nitrophenol to 4-aminophenol in presence of NaBH<SUB>4</SUB>, and the catalytic kinetic for the hydrogenation was analyzed <I>via</I> an UV–Vis spectrometer.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Synthesis and Cell Death Mechanism of a Militarin Derivative
Fei Chen,Deok Hyo Yoon,Dinneswara Reddy,Changwoo Han,최성아,조재열,성기호,황기철,김태웅,박해일 대한화학회 2016 Bulletin of the Korean Chemical Society Vol.37 No.3
Militarin, a novel anticancer substance from a caterpillar-grown traditional insect-flower (Cordyceps militaris), was previously isolated and characterized as an ether compound of 4-tert-octylphenol and a nonaethylene glycol. Among militarin analogs with different numbers of ethylene glycol substructure, the analog with four ethylene glycol substructure (M4EG) exhibited potent anticancer activities. A facile and scalable synthetic pathway of the M4EG was developed and the mechanism of cell death by the M4EG against lung adenocarcinoma epithelial cell line (A549) was explored. The results of this study showed that apoptosis of M4EG toward A549 cells is mediated by a caspase-dependent death-signaling pathway.
Thanh Nguyen Huu,Shaariikhuu Erdenechimeg,Nguyen Thi Xuyen,Hossain Muhammad Sarwar,Tae Eunju Lee,Reddy Guda Dinneswara,윤경병 대한화학회 2023 Bulletin of the Korean Chemical Society Vol.44 No.4
Cross-linked polystyrene and polydivinylbenzene (PDVB) have unreacted pendant vinyl groups. They readily undergo aging or oxidation with air even at room temperature, giving rise to formation of OH and (CO)CH3 groups within the polymers. We now report that the aging process involves the release of carbon monoxide (CO) and hydrogen (H2) in significant amounts at 40 C and the rate increases with time and temperature. The amounts of CO and H2 released from PDVB at a given temperature can be expressed using a polyno- mial equation of Aa = Bt + Ct2, where Aa is the accumulated amount, t is the time in the unit of day, and B and C are the coefficients. The coefficients B and D increase with increasing temperature. This result shows that the storage rooms for the above polymers and their composites should be well ventilated to prevent inhalation of CO by the workers and H2-induced potential hazards.