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- 저자 : Deng Yufang (검색결과 3 건)
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Deng Yufang,Jiang Fan,Hu Fan,Liang Liang,Wang Yuejin 한국응용곤충학회 2021 Journal of Asia-Pacific Entomology Vol.24 No.4
Bactrocera dorsalis and its larvae have evolved to cope with the hypoxic environment during their lifetime. In this study, we sequenced the transcriptomes of B. dorsalis under and post anoxia stress. Our data revealed the different biological mechanisms of B. dorsalis in response to anoxia and during recovery from anoxia. The in duction of heat shock proteins (HSPs) might be one of the important mechanisms for B. dorsalis to tolerate anoxia. Furthermore, our data showed B. dorsalis acquires energy through gluconeogenesis rather than glycolysis under anoxia and upregulated its lipid metabolism post anoxia. The up-regulation of the genes involved in the Hippo signaling pathway might also play a role in eliminating damaged cells as a result of anoxia. Furthermore, the HIF system of B. dorsalis did not change in response to anoxia stress in this study. We hypothesized that the HIF system in B. dorsalis might be activated by a specific duration of anoxia.
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Comparative portrayal of ocular surface microbe with and without dry eye
ZhenHao Li,Yufang Gong,ShuZe Chen,SiQi Li,Yu Zhang,HuiMin Zhong,ZhouCheng Wang,YiFan Chen,QiXin Deng,YuTing Jiang,LiYing Li,Min Fu,GuoGuo Yi 한국미생물학회 2019 The journal of microbiology Vol.57 No.11
To compare the ocular surface (OS) microbial communities and diversity between dry eye (DE) and non-DE (NDE). Furthermore, we compared meibomian gland dysfunction (MGD) and non-MGD (NMGD) among DE subjects. The V3-V4 region of 16S rRNA gene high-throughput sequencing was performed in the conjunctival swab samples to investigate the composition of the OS bacterial community in DE (n=35) and NDE (n=54) and compared the composition of MGD (n=25) and NMGD (n=10) among DE subjects. Deep sequencing of OS 16S rDNA from DE (n=35) and NDE (n=54) demonstrated great a difference in alpha and beta diversity between the OS bacterial flora (P < 0.05). The similar OS microbial structures were shown at the phylum and genus levels by bioinformatics analysis between them, and in LEfSe (linear discriminant analysis effect size) analysis, Bacteroidia and Bacteroidetes were enriched in DE, while Pseudomonas was plentiful in NDE (linear discriminant analysis [LDA] > 4.0). Among the DE group, there was no significant difference in α and β diversity between MGD and NMGD (P > 0.05). Surprisingly, Bacilli was the dominant microbe in MGD, and Bacteroidetes was the superior bacteria in NMGD among DE subjects (LDA > 4.0). Different diversity of OS bacteria composition between DE and NDE and the altered diversity of OS bacteria may play an important role in DE. Moreover, the lower dominance of OS bacteria in DE may be associated with the occurrence and development of DE. Although there was no significant difference in alpha and beta analysis, the OS dominant microbe between MGD and NMGD among DE was different.
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Yu Fang,Yanqing Li,Xin Liao,Jie Deng,Qiannan Wang,Jingtao Liang,Bohua Yan 한국식품영양과학회 2023 Journal of medicinal food Vol.26 No.12
Depression, a prevalent psychiatric disorder, presents a serious health risk to humans. Increasing evidencesuggested that the gut microbiota and the 5-hydroxytryptamine (5-HT) pathway both contribute significantly to depression. This research aimed to investigate how Corydalis yanhusuo polysaccharides (CYP) could potentially alleviate depressioninduced by chronic unpredictable mild stress in mice, as well as its underlying mechanism. The sucrose preference test, tailsuspension test, and forced swimming test were employed to evaluate the behavior of mice. Enzyme-linked immunosorbentassay and PCR techniques were utilized to measure depression-related factors (dopamine [DA], 5-HT, norepinephrine [NE],brain-derived neurotrophic factor [BDNF], tryptophan hydroxylase 2 [TPH-2], 5-hydroxytryptophan [5-HTP], and tryptophanhydroxylase [TPH-1] levels). Hematoxylin and eosin staining and Nissl staining were conducted to observe histopathologicalchanges in the hippocampus, the differences in the diversity of gut flora between groups were analyzed using 16S rRNAsequencing, and gas chromatography–mass spectrometry metabolomics was utilized to evaluate short-chain fatty acid (SCFA)concentrations. The findings indicated that CYP treatment increased the sucrose preference index, decreased the immobilitytime, and improved neuropathological injury. In depressed mice, CYP improved the dysregulation of the gut microbiota, andincreased the SCFA levels. In addition, CYP enhanced the DA, 5-HT, NE, BDNF, and TPH-2 levels in the brain and theexpression of 5-HTP and TPH-1 in the colon, while SCFAs were positively correlated with these levels. In summary, ourstudy suggested that CYP may mitigate depression by ameliorating gut microbiota dysregulation, promoting the generation ofSCFAs, and activation of 5-HT signaling expression.
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