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Lin, Jian-Ying,Wang, Ming-Sheng,Dong, Liang-Peng,Xu, Da-Wei,Wang, Ying,Li, Xue-Liang,Li, Xiu-Min Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.11
The aim of this study was to investigate QoL (quality of life) of patients with esophageal cancer in northern Henan province, China, and to accurate evaluate and reflect the relationship between patient characteristics and QoL. In the high risk area of esophageal cancer in the north of Henan province, 735 patients with esophageal cancer were investigated. The Eysenck personality questionnaire (EPQ) and QoL were analyzed by using the questionnaire of general situation, EPQ, QLQ-C30 and QLQ-OES18. The effects of personal character on the QoL of esophageal carcinoma patients were analyzed by SPSS 11.0 software. The QoL of esophageal cancer patients in Northern Henan region was significantly affected by character. The difference between choleric and type of melancholic temperament types was significant (P<0.01), also in OESEAT, OESTA, OESCO and OESSP (P<0.05). Differences in personal character can thus influence the quality of esophageal cancer patient lives.
Qi, Wei-Xiang,Shen, Zan,Lin, Feng,Sun, Yuan-Jue,Min, Da-Liu,Tang, Li-Na,He, Ai-Na,Yao, Yang Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.10
Purpose: To compare the efficacy and safety of epidermal growth factor receptor tyrosine kinase inhibitormonotherapy (EFGR-TKIs: gefitinib or erlotinib) with standard second-line chemotherapy (single agent docetaxel or pemetrexed) in previously treated advanced non-small-cell lung cancer (NSCLC). Methods: We systematically searched for randomized clinical trials that compared EGFR-TKI monotherapy with standard second-line chemotherapy in previously treated advanced NSCLC. The end points were overall survival (OS), progression-free survival (PFS), overall response rate (ORR), 1-year survival rate (1-year SR) and grade 3 or 4 toxicities. The pooled hazard ratio (HR) or risk ratio (RR), with their corresponding 95% confidence intervals (CI) were calculated employing fixed- or random-effects models depending on the heterogeneity of the included trials. Results: Eight randomized controlled trials (totally 3218 patients) were eligible. Our meta-analysis results showed that EGFR-TKIs were comparable to standard second-line chemotherapy for advanced NSCLC in terms of overall survival (HR 1.00, 95%CI 0.92-1.10; p=0.943), progression-free survival (HR 0.90, 95%CI 0.75-1.08, P=0.258) and 1-year-survival rate (RR 0.97, 95%CI 0.87-1.08, P=0.619), and the overall response rate was higher in patients who receiving EGFR-TKIs(RR 1.50, 95%CI 1.22-1.83, P=0.000). Sub-group analysis demonstrated that EGFR-TKI monotherapy significantly improved PFS (HR 0.73, 95%CI: 0.55-0.97, p=0.03) and ORR (RR 1.96, 95%CI: 1.46-2.63, p=0.000) in East Asian patients, but it did not translate into increase in OS and 1-year SR. Furthermore, there were fewer incidences of grade 3 or 4 neutropenia, febrile neutropenia and neutrotoxicity in EGFR-TKI monotherapy group, excluding grade 3 or 4 rash. Conclusion: Both interventions had comparable efficacy as second-line treatments for patients with advanced NSCLC, and EGFR-TKI monotherapy was associated with less toxicity and better tolerability. Moreover, our data also demonstrated that EGFR-TKImonotherapy tended to be more effective in East Asian patients in terms of PFS and ORR compared with standard second-line chemotherapy. These results should help inform decisions about patient management and design of future trials.
Expression and characterization of RNA-dependent RNA polymerase of Ectropis obliqua virus
( Mei Juan Lin ),( Shan Ye ),( Yi Xiong ),( Da Wei Cai ),( Jia Min Zhang ),( Yuan Yang Hu ) 한국생화학분자생물학회 (구 한국생화학회) 2010 BMB Reports Vol.43 No.4
Replication of positive-strand RNA virus is mediated by a virus- encoded RNA-dependent RNA polymerase (RdRp). To study the replication of Ectropis obliqua virus (EoV), a newly identified insect virus belonging to the family Iflaviradae, we expressed the RNA polymerase domain in Escherichia coli and purified it on a Ni-chelating HisTrap affinity column. It is demonstrated that EoV RdRp initiated RNA synthesis in a primer- and poly (A)-dependent manner in vitro. Furthermore, the effect of primer concentration, temperature, metal ions (Mg2+, Mn2+, and K+) on enzymatic activity were determined. Our study represented a first step towards understanding the mechanism of EoV replication. [BMB reports 2010; 43(4): 284-290]
Multiscale self-coordination of bidimensional empirical mode decomposition in image fusion
( Feng-ping An ),( Xian-wei Zhou ),( Da-chao Lin ) 한국인터넷정보학회 2015 KSII Transactions on Internet and Information Syst Vol.9 No.4
The bidimensional empirical mode decomposition (BEMD) algorithm with high adaptability is more suitable to process multiple image fusion than traditional image fusion. However, the advantages of this algorithm are limited by the end effects problem, multiscale integration problem and number difference of intrinsic mode functions in multiple images decomposition. This study proposes the multiscale self-coordination BEMD algorithm to solve this problem. This algorithm outside extending the feather information with the support vector machine which has a high degree of generalization, then it also overcomes the BEMD end effects problem with conventional mirror extension methods of data processing, . The coordination of the extreme value point of the source image helps solve the problem of multiscale information fusion. Results show that the proposed method is better than the wavelet and NSCT method in retaining the characteristics of the source image information and the details of the mutation information inherited from the source image and in significantly improving the signal-to-noise ratio.
THE MAGNETIC SEPARATION OF Nd - Fe - B POWDERS
Li-Ya Cui,Da-Li Zheng,Jing-Han Zhu,Wei-Hong Zhao,Shu-Lin Ding 한국자기학회 1995 韓國磁氣學會誌 Vol.5 No.5
The magnetic separation of Nd-Fe-B powders prepared by melt-spun and HDDR processes was investigated. The experiments show that the ununiform melt-spun powders can be separated into various standards by means of magnetic separation method. The magnetic powders with higher properties were obtained by the use of suitable separating field. For example, the properties of ununiform melt-spun powders are Br=7.95 kG, iHc=9.93 kOe and (BH)max=10.2 MGOe before separating. Through separating in different magnetic fields, the powders obtained with a separating field of 780 Oe has the optimum properties of Br=7.7 kG, iHc=11.0 kOe and (BH)max=15.3 MGOe. The magnetic properties of the HDDR magnetic powder are hardly separated by the magnetic separation method.
Xu-Yang Wang,Da-Jun Yuan,Da-Long Jin,Wei-Lin Su 대한토목학회 2020 KSCE JOURNAL OF CIVIL ENGINEERING Vol.24 No.5
In the long-distance shield tunneling process, the shield tail brush needs to be replaced after wear failure, especially in cross-river and cross-sea tunnel projects. Taking the shield tail brush replacement project of Qingchun Road tunnel in Hangzhou, China as the research background, a three-dimensional sequential thermo-mechanical coupled numerical simulation was carried out to study the shield tail brush replacement with liquid nitrogen freezing by ABAQUS software. The development of temperature fields and displacement fields of soil, and the deformations of the tunnel sections along the longitudinal direction induced by freezing were obtained. The numerical model was further validated by site measurement. In addition, the effects of the frozen wall thickness, buried depth, excavation radius, and coefficients of linear thermal expansion of soils on the frost heave were studied.
Characterization of Protein Arginine Methyltransferases in Porcine Brain
Hung, Chien-Jen,Chen, Da-Huang,Shen, Yi-Ting,Li, Yi-Chen,Lin, Yi-Wei,Hsieh, Mingli,Li, Chuan Korean Society for Biochemistry and Molecular Biol 2007 Journal of biochemistry and molecular biology Vol.40 No.5
Protein arginine methylation is a posttranslational modification involved in various cellular functions including cell signaling, protein subcellular localization and transcriptional regulation. We analyze the protein arginine methyltransferases (PRMTs) that catalyze the formation of methylarginines in porcine brain. We fractionated the brain extracts and determined the PRMT activities as well as the distribution of different PRMT proteins in subcellular fractions of porcine brain. The majority of the type I methyltransferase activities that catalyze the formation of asymmetric dimethylarginines was in the cytosolic S3 fraction. High specific activity of the methyltransferase was detected in the S4 fraction (high-salt stripping of the ultracentrifugation precipitant P3 fraction), indicating that part of the PRMT was peripherally associated with membrane and ribosomal fractions. The amount and distribution of PRMT1 are consistent with the catalytic activity. The elution patterns from gel filtration and anion exchange chromatography also indicate that the type I activity in S3 and S4 are mostly from PRMT1. Our results suggest that part of the type I arginine methyltransferases in brains, mainly PRMT1, are sequestered in an inactive form as they associated with membranes or large subcellular complexes. Our biochemical analyses confirmed the complex distribution of different PRMTs and implicate their regulation and catalytic activities in brain.
Chun-Hao Yang,Wu-Ning Ma,Da-wei Ma,Qiang He,Jian-Lin Zhong 대한기계학회 2018 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.32 No.6
The low velocity impact analysis of functionally graded carbon nanotubes reinforced composite (FG-CNTRC) spherical shells including the contact force and indentation of the shell surface center was presented. The material properties were set according to the rule of mixture. The fibers and polymeric matrix were temperature-dependent. Timoshenko-Midlin assumption was used to establish the dimensionless nonlinear governing equations of the axis-symmetric transverse isotropy spherical shells. The Hertz contact theory was established to obtain the force and displacement between the spherical shell and impactor. Seven species of comparison analyses including grading profiles and volume fraction were mentioned to investigate the influence on the low velocity impact response of the FG-CNTRC spherical shells. The results revealed that the contact force was determined by the material properties of both contact surface and noncontact surface collectively. Furthermore, the increase of volume fraction can result in the larger contact force and shorter contact time.
Mechanical behavior of crumb rubber concrete under axial compression
Ren, Rui,Liang, Jiong-Feng,Liu, Da-wei,Gao, Jin-he,Chen, Lin Techno-Press 2020 Advances in concrete construction Vol.9 No.3
This paper aims at investigating the effect of crumb rubber size and content on compressive behaviors of concrete under axial compression. Concrete specimens are designed and produced by replacing natural aggregate with crumb rubber content of 0%, 5%, 10%, 15% and three different sized crumb rubbers (No. 20, No. 40, No. 80 crumb rubber). And the failure mode, compressive strength, elastic modulus, stress-strain curves, peak strain and ultimate strain are experimentally studied. Based on the test results, formulas have been presented to determine the compressive strength, elastic modulus, the relationship between prism compressive strength and cube compressive strength, stress-strain curves and peak strain of crumb rubber concrete (CRC). It is found that the proposed formulas agree well with the test result on the whole, which may be used to practical applications.