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Isomorphic identification for kinematic chains using variable high-order adjacency link values
Leiying He,Faxin Liu,Liang Sun,Chuanyu Wu 대한기계학회 2019 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.33 No.10
Isomorphism identification is a crucial issue in the type synthesis of kinematic chains (KCs). To date, various topological characteristics have been used to detect isomorphism, but the manner of the correspondence between two isomorphic KCs has seldom been investigated. In this paper, a method using variable high-order adjacency link values to identify isomorphisms in KCs is proposed. First, the definition of improved high-order adjacency link values, which are used to describe the characteristics of KCs, is introduced in detail. The variable high-order adjacency link values are then calculated repeatedly through reassignment procedure according to the repetitions of their elements for one KC. Finally, isomorphisms are identified and all manner of the correspondence are detected by comparing two high-order adjacency link strings from two KCs. The proposed method is tested on 8-link, 15-link, and 28-link KCs, and all results demonstrate its feasibility and efficiency.
Sung Min Kim,Seon Ho Ahn,Ju Hung Song,Bong Kyu Choi,Chuanyue Wu,Kyu Yong Jung,Nari Kim,Seoul Lee,Do Kyung Kim,Yu Min Lee 생화학분자생물학회 2007 Experimental and molecular medicine Vol.39 No.4
TGF-β1-induced glomerular mesangial cell (GMC) in-jury is a prominent characteristic of renal pathology in several kidney diseases, and a ternary protein com-plex consisting of PINCH-1, integrin-linked kinase (ILK) and α-parvin plays a pivotal role in the regulation of cell behavior such as cel proliferation and hyper-trophy. We report here that PINCH-1-ILK-α-parvin (PIP) complex regulates the TGF-βliferation and hypertrophy in cultured rat GMCs. When GMCs were treated with TGF-β1 for 1, 2 and 3 days, the PIP complex formation was up-regulated after 1 day, but it was down-regulated on day 2. Cell numbers were significantly elevated on day 2, but dramatically decreased on day 3. In contrast, a sig-nificant increase in cellular protein contents was ob-served 3 days after TGF-β1-treatment. TGF-β1 in-duced early increase of caspase-3 activity. In GMCs β1 for 2 days, cytosolic ex-pression of p27Kip1 was dramatically reduced, but its nuclear expression was remarkably elevated. A sig-nificantly decreased expression of phospho-Akt (Ser 473) was observed in the cells treated with TGF-β1 for 1 day. TGF-β1 induced early increase of phos-pho-p27Kip1(Thr 157) expression with subsequent de-crease, and similar responses to TGF-β1 were ob-Taken together, TGF-β1 differently regulates the PIP complex formation of GMCs in an incubation peri-od-dependant fashion. The TGF-β1-induced up- and down-regulation of the PIP complex formation likely contributes to the pleiotropic efects of TGF-β1 on mesangial cell proliferation and hypertrophy through cellular localization of p27Kip1and alteration of Akt and p38 phosphorylation. TGF-β1-induced alteration implicated in the development and progression of glomerular failure shown in several kidney diseases.
Jing-Hong Li,Qiang Wang,Gao-Hong Yu,Chuanyu Wu 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.1
Drivers who lack sufficient experience would be unable to achieve handling stability due to the variationand dynamics of the combined vehicles (CVs). Drivers face hurdles in the stabilization attempt once these vehiclesare rendered unstable. In this investigation, the use of the behavior of real vehicles to track the desired properties ofthe developed combined vehicles can help maintain good handling stability despite the present varying dynamics. This paper provides an appropriate design method for CVs to gain suitable handling property for such vehicles. Thedeveloped adaptive steering controller (ASC) allows the tracking of the desired vehicle by the real vehicle, despitethe variation of parameter and lack of information of the real vehicle. Simulation results are obtained to validate thatthe handling stability was improved by using one design parameter, which minimizes frequency oscillation causedin the wheel steering angles. The introduction of a driver model that can simulate the real vehicle demonstrated thatthe adoption of the ASC is useful in the driver-tractor-semitrailer system