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Effects of Ginseng Total Saponin on Stress-Induced Analgesia
Kim, Hack-Seang,Chung, Myeon-Woo,Jang, Choon-Gon,Park, Woo-Kyu,Oh, Ki-Wan The Korean Society of Ginseng 1993 Journal of Ginseng Research Vol.17 No.1
This study was undertaken to determine the effects of ginseng total saponin (GTS) on stress- induced analgesia (SIA) in mice. intermittent foot shock (FS)-SIA was antagonized not by on but by naloxone in the tail flick FS-SIA which was not antagonized by naloxone in the T.F. test. On the other hand, GTS did not antagonize the continuous FS-SIA naloxone antagonized in the T.P. test. Also GTS antagonized psychological (PSIF)-SIA which was not antagonized by naloxone in the T.F. test. However, GTS did not antagonize the PSY-SIA which naloxone antagonized in the T.P. test. Forced swimming (FSIP)-SIA was not affected by both GTS and naloxone. These results suggest that the antapeonisms of intermittent FS-SIA in the T.F. test, continuous FS-SIA and PSY-SIA by GTS are mediated by non-opioid mechanisms but the antagonism of intermittent FS-SIA in the T.P. test by GTS is mediated by opioid mechanism.
Effects of the CYP2D6*10 allele on the pharmacokinetics of atomoxetine and its metabolites
Byeon, Ji-Yeong,Kim, Young-Hoon,Na, Han-Sung,Jang, Jong-Hwa,Kim, Se-Hyung,Lee, Yun-Jeong,Bae, Jung-Woo,Kim, In Su,Jang, Choon-Gon,Chung, Myeon-Woo,Lee, Seok-Yong Springer-Verlag 2015 Archives of Pharmacal Research Vol.38 No.11
Medial Unicompartmental Knee Arthroplasty in Patients with Spontaneous Osteonecrosis of the Knee
Won Sik Choy,Kap Jung Kim,Sang Ki Lee,Dae Suk Yang,Choon-Myeon Kim,Ju Sang Park 대한정형외과학회 2011 Clinics in Orthopedic Surgery Vol.3 No.4
Background: We analyzed the clinical and radiologic results of patients with spontaneous osteonecrosis of the knee treated byminimally invasive medial unicompartmental arthroplasty using Oxford Uni. Methods: We reviewed 22 knees in 21 patients which were treated for spontaneous osteonecrosis between 2002 and 2006. Patientsincluded one male and 20 females. The mean age was 70.8 years (range, 53 to 82 years). The mean follow-up period was70.3 months (range, 48 to 93 months). The clinical results were evaluated using the Hospital for Special Surgery (HSS) knee scoreand the range of motion of the knee preoperatively and at the fi nal follow-up. Preoperative plain radiographs and magnetic resonanceimages were analyzed to determine the size and stage of osteonecrotic lesions. Results: The mean HSS knee score was 64.3 (range, 54 to 75) preoperatively and 92.0 (range, 71 to 100) at the fi nal follow-up. The mean preoperative fl exion contracture was 8.9o (range, 0 to 15o) and 0.2o (range, 0 to 5o) at the fi nal follow-up. The mean furtherfl exion increased from 138.6o (range, 100 to 145o) preoperatively to 145.6o (range, 140 to 150o) at the fi nal follow-up. Activefull fl exion was possible within 2 months of the operation. The squatting position was possible in 16 patients (84.2%) out of 19,except one case of bronchiectasis and one case of spine fracture. The cross-leg posture was possible in 19 patients (90.5%) out of21. The mean tibiofemoral angle was improved from varus 0.98o to valgus 3.22o. Meniscal bearing dislocation occurred in 2 casesand femoral component loosening occurred in 1 case. Conclusions: Unicompartmental knee arthroplasty using Oxford Uni could be an alternative treatment option in spontaneous osteonecrosisof the knee.
The Analysis of the Treatment Outcomes of Proximal Humeral Fractures with Locking Plates
Kwang-Won Lee,Yoon-Sub Hwang,Choon-Myeon Kim,Dae-Suk Yang,Tae-Soo Park 대한견주관절의학회 2014 대한견주관절학회지 Vol.17 No.1
Background: The aim of this study was to assess the clinical outcomes after treatment of proximal humeral fractures with locking plates, and to determine which factors influence the clinical and radiological outcomes. Methods: Fifty six patients who were treated with locking plates for proximal humeral fractures and had been followed for more than 1 year were enrolled in this study. We performed functional evaluation using the Constant score and analyzed radiographic results. The following factors that may potentially influence the clinical outcomes were assessed: age, gender, type of fracture, presence of medial metaphyseal comminution, bone mineral density, anatomical reduction, restoration of medial mechanical support, and postoperative complications. Results: The mean Constant score was 70.1 points at the final follow-up. Female gender, 4-part fractures, AO type-C fractures, and fractures with medial metaphyseal comminution were associated with a poor clinical outcome. On the other hand, restoration of medial mechanical support and accurate anatomical reduction had a positive influence on clinical outcomes. Postoperative complications resulted in 3 patients (intra-articular screw perforation: 1 patient, varus deformity with screw loosening: 1 patient, nonunion: 1 patient). Conclusions: When treating proximal humeral fractures with locking plate fixation, following factors: a female gender, Neer type 4-part fracture, AO type C fracture, and medial metaphyseal comminution are important risk factors that surgeons should take into consideration. Factors that contribute to better clinical outcomes of operative treatment for humeral fractures are accurate anatomical reduction and restoration of medial mechanical support.