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Lee, Seungmin,Moon, Byung Joon,Lee, Hyun Jung,Bae, Sukang,Kim, Tae-Wook,Jung, Yong Chae,Park, Jong Hyeok,Lee, Sang Hyun American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.20
<P>In this study, we developed reduced graphene oxide (rGO)-incorporated porous agarose (Ar-rGO) composites that were prepared via a “one-pot” sol-gel method involving a mixing and vacuum freeze-drying process. These composites represent an easy-to-use adsorbent for organic contaminant removal. Ar-rGOs can efficiently adsorb organic molecules, especially aromatic organic compounds from wastewater, because of the synergistic effect between the agarose bundles, which function as a water absorption site, and the rGO sheets, which function as active sites for pollutant binding. The pore structures and morphology of the Ar-rGO composites varied according to the added rGO, resulting in effective water infiltration into the composites. The main adsorption mechanism of the aromatic organic compounds onto Ar-rGOs involved π-π interactions with the rGO sheets. The surface interaction was more effective for adsorbing/desorbing the aromatic pollutants than the electrostatic interaction via the O-containing functional groups. In addition, we confirmed that Ar-rGO is highly stable over the entire pH range (1-13) because of the presence of the rGO sheets.</P> [FIG OMISSION]</BR>
Lee, Jung Hoon,Kim, Nayoung,Chung, Jae Il,Kang, Kyung Phil,Lee, Sang Hyup,Park, Young Soo,Hwang, Jin-Hyeok,Kim, Jin-Wook,Jeong, Sook-Hyang,Lee, Dong Ho,Jung, Hyun Chae,Song, In Sung Wiley (Blackwell Publishing) 2008 HELICOBACTER -CAMBRIDGE USA- Vol.13 No.4
<P>BACKGROUND: Serology is widely used for epidemiologic research of Helicobacter pylori. However, there is limited information on the long-term follow up of H. pylori titers after eradication. In addition, it is presumed that the reinfection rate decreases as the H. pylori infection rate decreases. The aim of this study was to investigate the long-term follow up of H. pylori IgG, and to evaluate the reinfection rate of H. pylori in Korea. METHODS: Among 247 patients, who were enrolled during 2003-07, 185 patients with invasive H. pylori test positive received proton pump inhibitor-based triple therapy, and follow-up H. pylori testing, including histology, CLOtest, culture, and serology, were evaluated 2, 10, and 18 months after H. pylori eradication. RESULTS: The initial H. pylori IgG optical density (OD(450 nm)), 2.06, gradually decreased to 0.63 (67% reduction) at 18 months after H. pylori eradication. The seroreversion rate was 5, 10, and 45% at 2, 10, and 18 months after H. pylori eradication, respectively. The recrudescence of H. pylori was 3.49%, and the annual reinfection rate was 2.94% per year. H. pylori IgG titers abruptly increased in cases with recrudescence and reinfection, and correlated with the results of the invasive H. pylori tests. CONCLUSION: The results of this study showed that H. pylori IgG serology could be used for the determination of reinfection of H. pylori, but not for the diagnosis of H. pylori eradication. The reinfection rate of H. pylori, in Korea, was found to be very low, 2.94% per year.</P>
Tristetraprolin regulates expression of VEGF and tumorigenesis in human colon cancer
Lee, Hyun Hee,Son, Young Joon,Lee, Won Hyeok,Park, Young Woo,Chae, Seoung Wan,Cho, Wha Ja,Kim, Young Min,Choi, Hye‐,Jeong,Choi, Dae Hwa,Jung, Seok Won,Min, Young Joo,Park, Soon Eun,Lee, Byung Ju Wiley Subscription Services, Inc., A Wiley Company 2010 International journal of cancer: Journal internati Vol.126 No.8
<P><B>Abstract</B></P><P>Tristetraprolin (TTP) is an AU‐rich element‐binding protein that regulates mRNA stability. Here, we report that TTP suppress the growth of human colon cancer cells both <I>in vivo</I> and <I>in vitro</I> by regulating of the expression of vascular endothelial growth factor (VEGF). TTP protein expression in human colonic tissues was markedly decreased in colonic adenocarcinoma compared with in normal mucosa and adenoma. VEGF expression was higher in colonic adenocarcinoma than in normal mucosa and adenoma. Specific inhibition of TTP expression by RNA‐interference increased the expression of VEGF in cultured human colon cancer cells, and TTP overexpression markedly decreased it. In addition, elevated expression of TTP decreased the expression level of luciferase linked to a 3′ terminal AU‐rich element (ARE) of VEGF mRNA. Colo320/TTP cells overexpressing TTP grew slowly <I>in vitro</I> and became tumors small in size when xenografted <I>s.c</I> into nude mice. These findings demonstrate that TTP acts as a negative regulator of VEGF gene expression in colon cancer cells, suggesting that it can be used as novel therapeutic agent to treat colon cancer.</P>
( Daewoo Lee ),( Sung Ho Kook ),( Hyeok Ji ),( Seung Ah Lee ),( Ki Choon Choi ),( Kyung Yeol Lee ),( Jeong Chae Lee ) 생화학분자생물학회(구 한국생화학분자생물학회) 2015 BMB Reports Vol.48 No.11
There are controversial findings regarding the roles of nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway on bone metabolism under oxidative stress. We investigated how Nrf2/HO-1 pathway affects osteoblast differentiation of MC3T3-E1 cells in response to hydrogen peroxide (H2O2), N-acetyl cysteine (NAC), or both. Exposing the cells to H2O2 decreased the alkaline phosphatase activity, calcium accumulation, and expression of osteoblast markers, such as osteocalcin and runt-related transcription factor-2. In contrast, H2O2 treatment increased the expression of Nrf2 and HO-1 in the cells. Treatment with hemin, a chemical HO-1 inducer, mimicked the inhibitory effect of H2O2 on osteoblast differentiation by increasing the HO-1 expression and decreasing the osteogenic marker genes. Pretreatment with NAC restored all changes induced by H2O2 to near normal levels in the cells. Collectively, our findings suggest that H2O2-mediated activation of Nrf2/HO-1 pathway negatively regulates the osteoblast differentiation, which is inhibited by NAC. [BMB Reports 2015; 48(11): 636-641]
이재혁(Chae Hyeok Lee),박현민(Hyun Min Park),이백희(Baeck Hee Lee),김윤환(Yun Hwan Kim),이정구(Chung Ku Rhee) 대한소아신경학회 2001 대한소아신경학회지 Vol.9 No.2
목 적 : 소아에서의 어지러움은 흔한 증상은 아니지만 적지 않은 소아들이 어지러움을 주증상으로 호소하기 때문에 진단과 치료를 위해서는 이에 대한 평가와 자료의 분석이 꼭 필요하다. 저자들은 어지러움을 주증상으로 하는 소아 환자를 대상으로 소아 어지러움의 임상 양상 및 원인 질환을 밝혀보고자 하였다. 방 법 : 단국대학교병원에 어지러움을 주증상으로 내원한 85명의 소아 환자에 대한 의무기록을 검토하여 병력, 진찰, 청력 검사, 방사선학적 검사와 전정기능검사에 대한 결과를 조사하였다. 결 과 : 소아기 양성 돌발성 어지러움이 38.8%로 가장 많았고 편두통성 어지러움과 외상 후 어지러움이 각각 17.6%, 12.9%이었다. 12세 미만에서는 소아기 양성 돌발성 어지러움이, 12세 이상에서는 편두통성 어지러움이 가장 많았다. 전정기능검사 중 전기안진검사와 회전의자검사를 받은 환아 중에서는 각각 11.2%, 21.2%에서 이상이 발견되었고, 동적자세검사를 받은 환아 중 44.4%에서 지각 조절검사의 전정장애 점수가 50점 이하였다. 결 론: 소아에서 흔한 어지러움증은 소아기 양성 돌발성 어지러움과 편두통성 어지러움이고 이러한 질환을 위한 진단적 검사는 없으므로 원인이 뚜렷하지 않은 소아 어지러움의 진단을 위해서는 자세한 병력조사와 소아 어지러움에 대한 폭넓은 이해가 중요함을 알 수 있었다. 목 적 : 소아에서의 어지러움은 흔한 증상은 아니지만 적지 않은 소아들이 어지러움을 주증상으로 호소하기 때문에 진단과 치료를 위해서는 이에 대한 평가와 자료의 분석이 꼭 필요하다. 저자들은 어지러움을 주증상으로 하는 소아 환자를 대상으로 소아 어지러움의 임상 양상 및 원인 질환을 밝혀보고자 하였다. 방 법 : 단국대학교병원에 어지러움을 주증상으로 내원한 85명의 소아 환자에 대한 의무기록을 검토하여 병력, 진찰, 청력 검사, 방사선학적 검사와 전정기능검사에 대한 결과를 조사하였다. 결 과 : 소아기 양성 돌발성 어지러움이 38.8%로 가장 많았고 편두통성 어지러움과 외상 후 어지러움이 각각 17.6%, 12.9%이었다. 12세 미만에서는 소아기 양성 돌발성 어지러움이, 12세 이상에서는 편두통성 어지러움이 가장 많았다. 전정기능검사 중 전기안진검사와 회전의자검사를 받은 환아 중에서는 각각 11.2%, 21.2%에서 이상이 발견되었고, 동적자세검사를 받은 환아 중 44.4%에서 지각 조절검사의 전정장애 점수가 50점 이하였다. 결 론: 소아에서 흔한 어지러움증은 소아기 양성 돌발성 어지러움과 편두통성 어지러움이고 이러한 질환을 위한 진단적 검사는 없으므로 원인이 뚜렷하지 않은 소아 어지러움의 진단을 위해서는 자세한 병력조사와 소아 어지러움에 대한 폭넓은 이해가 중요함을 알 수 있었다.
박승혁 ( Seung Hyeok Park ),채민수 ( Min Soo Chae ),장준복 ( Jun Bock Jang ),이진무 ( Jin Moo Lee ),이창훈 ( Chang Hoon Lee ),이경섭 ( Kyung Sub Lee ),황덕상 ( Deok Sang Hwang ) 대한한방부인과학회 2014 大韓韓方婦人科學會誌 Vol.27 No.4
Objectives: This study aims to identify effects of Korean medical treatment for stress urinary incontinence patient. Methods: The patient was treated by moxibustion at Shuidao (ST28), Sa-Am acupuncture lung tonification, Bojungikkitang-gamibang and Boshimdan for 2 weeks. These treatments are Korean medical treatment, and non-invasive. Results: After 2 weeks of Korean medical treatment, the symptoms of stress urinary incontinence disappeared. Conclusions: This case report shows that non-invasive Korean medical treatments are effective against stress urinary incontinence.
한국 한려해상국립공원 서부 조간대 저서다모류 동물상 연구
이건혁(Geon Hyeok Lee),이하은(Ha-Eun Lee),지수정(Su-Jung Ji),채규석(Kyu-Seok Chae),민기식(Gi-Sik Min) 국립공원연구원 2021 국립공원연구지 Vol.12 No.1
본 연구는 한려해상국립공원(서부) 경성조간대와 연성조간대의 저서성 다모류에 대한 종류상, 분포상 그리고 군집구조를 파악하기 위해 2020년에 조사를 시행하였다. 저서다모류의 출현종수는 6목28과121종, 개체밀도는 188.8개체/㎡로 확인되었다. 경성기질에서는 굵은석회관갯지렁이(28.4%), 연성기질에서는 얼굴갯지렁이류(20.9%)가 우점하는 것으로 확인되었다. 전체정점에 대한 우점도는 0.21, 다양도는 3.38 그리고 종풍부도는 22.90으로 확인되었다. 다양한 생태지수를 고려해 보면, 남해대교지구(st. 5, 6)에 비해 사천지구(st. 1, 3)와 상주·금산지구(st. 7, 8)의 다모류 군집이 생태학적으로 안정하다는 것을 알 수 있다. 출현종과 개체밀도에 따른 집괴분석 결과는 생태기질의 종류에 따라 조사정점들이 묶이는 것을 확인하였다. 고착성으로 알려진 다모류 군집이 생태기질에 영향을 많이 받는 것으로 보인다. This study was carried out to investigate the species composition, distribution, and community structure of benthic polychaetes in the western intertidal zones of Hallyeohaesang National Park in 2020. The total number of benthic polychaetes was 121 species of 28 families in 6 orders. The mean density of community was 188.9 individual/m2. The major dominant species was Spirobranchus cf. kraussii (Baird, 1864) (28.4%) in the hard substrate, and Aonides aff. oxycephala (Sars, 1862) (20.9%) in the soft substrate. The biodiversity index and richness index for all sites were calculated as 3.38 and 22.90, respectively. Considering the various ecological indices, the polychaete communities of Sacheon district (st. 1, 3) and Sangju-Geumsan district (st. 7, 8) are more ecologically stable than those of Namhae Bridge district (st. 5, 6). From the cluster analysis based on the species composition and population density, study sites were grouped into ecological clades according to the type of ecological substrates. It seems that the polychaete communities are highly influenced by ecological substrates.
이침과 한약치료를 병행한 임신오조(姙娠惡阻) 환자 4례의 증상호전 및 안전성 보고
박승혁 ( Seung Hyeok Park ),채민수 ( Min Soo Chae ),김남훈 ( Nam Hoon Kim ),황덕상 ( Deok Sang Hwang ),이진무 ( Jin Moo Lee ),이창훈 ( Chang Hoon Lee ),이경섭 ( Kyung Sub Lee ),장준복 ( Jun Bock Jang ) 대한한방부인과학회 2013 大韓韓方婦人科學會誌 Vol.26 No.3
Objectives: To identify effects and safety of Korean traditional herbal medicine and auricular acupuncture for hyperemesis gravidarum patients. Methods: Korean traditional herbal medicine and auricular acupuncture were applied to 4 hyperemesis gravidarum patients, and we investigated changes of symptoms, continuance of pregnancy, and whether they delivered or not. Results: Hyperemesis gravidarum symptom was improved in 3 patients, and 1 patient showed complete recovery. Among them, 2 patients had children by natural childbirth, 1 patient had a repeat cesarean due to previous cesarean section, and 1 patient has been maintaining pregnancy well for 25weeks. Conclusions: It is confirmed that symptoms of hyperemesis gravidarum patients were improved by Korean traditional herbal medicine and auricular acupuncture, and these medical interventions are safe.