http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Intervention with costimulatory pathways as a therapeutic approach for graft-versus-host disease
Byungsuk Kwon 생화학분자생물학회 2010 Experimental and molecular medicine Vol.42 No.10
Graft-versus-host disease (GVHD) is mediated by mature donor T cells contained in the hematopoietic stem cell graft. During the development of GVHD, signaling through a variety of costimulatory receptors plays an important role in allogeneic T cell responses. Even though delivery of costimulatory signals is a prerequisite for full activation of donor T cells in the phase of their interactions with host APCs, their involvement with GVHD might occur over multiple stages. Like many other aspects of GVHD, promise of therapeutic interventions with costimulatory pathways has been gleaned from preclinical models. In this review, I summarize some of the advances in roles of costimulatory molecules in GVHD pathophysiology and discuss preclinical approaches that warrant further exploration in the clinic, focusing on novel strategies to delete pathogenic T cells.
The 3-Dimensional Active Earth Pressure and Load Transfer
( Byungsuk Park ),( Junho Jeong ),( Yunseok Kang ) 대한지질공학회 2019 대한지질공학회 학술발표회논문집 Vol.2019 No.2
In this study, it was experimentally tried to investigate the magnitude and the distribution of 3-dimensional active earth pressure and the magnitude and the influence range of transferred load to the adjacent ground. As results, the 3-dimensional active earth pressure were arrived at the horizontal wall displacements, which was approximately 0.13% of the wall height(h), and the resultant earth pressure was similar to that of Walz/Prager (1978) and Karstedt (1982). The distribution of the 3-dimensional active earth pressure showed that the earth pressure at the top and the bottom of a wall was relatively small, The largest earth pressure was measured at the height of 0.50~0.55h when the aspect ratio was larger than 1.2. The ratio of the 3-dimensional active earth pressure to the 2-dimensional active earth pressure was proposed as a reduction coefficient(a). The amount of the load transferred to adjacent ground was 61.7~81.9%. And the range of load transfer was 0.75~1.29w in the lateral direction, and 0.0~2.0h in the vertical direction when the aspect ratio was 0.1~2.7. The transferred load in horizontal direction was larger than that in vertical direction. The largest load was transferred at the boundary of active wall for both vertical and lateral directions. As the aspect ratio increased, the load transfer in horizontal direction increased gradually. A formula to predict the influence range of load transfer with the width of active wall was suggested for the aspect ratio 0.1 ~1.8.
An Experimental Verification Study on the Heat Flow Analysis Results of a Tube Furnace
Byungsuk Park,Sangwoon Kwon,Juho Lee,Changhwa Lee 한국방사성폐기물학회 2023 한국방사성폐기물학회 학술논문요약집 Vol.21 No.2
In general, systems are developed by repeatedly performing the processes of design, analysis, manufacturing, and performance testing. In particular, systems with temperature, pressure, and flow rate often utilize computational fluid dynamics tools at the design stage. In this paper, we aim to verify the reliability of the analysis results of Solidworks Flow Simulation, which is widely used in heat flow analysis at the design stage. A tube furnace was manufactured, various experiments were performed, and a study was conducted to compare the analysis results. The details of the experiment are as follows. First, an experiment was conducted in which the heater was heated to 900°C without insulating the exposed part of the tube. The detailed contents of the experiment are as follows; - Heating heater and measuring temperature without supplying flow inside the tube, - Tube flow supply (25°C, 15 lpm air) and heater heating/temperature measurement. Second, an experiment was performed in which the exposed part of the tube was insulated (thickness 50 mm) and the heater was heated to 900°C. The detailed contents of the experiment are as follows; - Insulate the outside of the tube except for the flanges at both ends of the tube, and heat the heater and measure the temperature without supplying flow inside the tube. - Insulate the outside of the tube except for the flanges at both ends of the tube, supply flow rate inside the tube (25°C, 15 lpm air) and measure heater heating/temperature. - Insulate the flange of the flow supply section, heat the heater and measure temperature without supplying flow inside the tube. - Insulate the flange of the flow supply section, heat the supply air (277°C, 15 lpm) and measure the temperature using a heating gun without heating the heater. - Insulate the flange of the flow supply section, supply heated air (277°C, 15 lpm) and measure heater heating/temperature. - Insulate the flange of the flow supply section and measure temperature according to heater heating (900°C) and supply temperature (25°C, 277°C 15 lpm). The following results were derived from the experimental and analysis results. - When the exposed part of the tube is insulated, the temperature inside the tube increases and the steady-state power decreases compared to non-insulated. - In areas with insulation, the temperature error between experiment and analysis results is not large. - When flow rate is supplied, there is a large temperature error in experiment and analysis results. - The temperature change after the center of the heater is not large for a temperature change of 15 lpm flow rate. From these results, it can be seen that Solidworks Flow Simulation has a significant difference from the experimental results when there is a flow rate in the tube. This was thought to be because the flow rate acts as a disturbance, and this cannot be sufficiently accounted for in the analysis. In the future, we plan to check whether there is a way to solve this problem.
Design and Fabrication of Automated Device for Salt Sample Analysis
Byungsuk Park,Sehwan Park,Jonghui Han 한국방사성폐기물학회 2023 한국방사성폐기물학회 학술논문요약집 Vol.21 No.2
As part of strengthening pyro safety measures, the Korea Atomic Energy Research Institute is developing LIBS (Laser-Induced Breakdown Spectroscopy) application technology to analyze molten salt components in electrolytic recovery device in real time. LIBS performs qualitative and quantitative analysis by analyzing the spectrum of energy emitted by atomizing and ionizing elements on the surface of a salt sample with a high-focused laser. Since salt easily corrodes metal, it must be managed in an environment with a dew point of -40°C or lower. In this study, we designed and manufactured a device that places a rod-type sampling stick on a mounting base, automatically moves it to the optimal measurement position for LIBS, and retrieves the sample. Its characteristics are as follows. First, LIBS is stationary and does not move. Second, the sample stick is placed on a mounting base and can rotate 360 degrees. Third, according to the command, the sample stick automatically moves to the optimal measurement position of LIBS with three degrees of freedom (X, Y, Z). Fourth, the salt attached to the sampling stick is recovered for chemical analysis by driving the gripper mounted at the bottom of the Z axis, Z axis, and rotation axis (R). The X, Y, and Z movement distances of this device are each 100 mm, rotation is 360 degrees, grip stroke is 50 mm, and position accuracy is ±20 ?m. Once the performance test of the automated salt sample analysis device is completed, it will be installed in a dry room with a dew point of - 40°C or lower. Samples will be collected remotely in connection with the electrolytic recovery device and gantry robot built in the dry room. We plan to conduct experiments to seat the sample stick. Ultimately, we plan to conduct comprehensive experiments in conjunction with LIBS.