Self-powered deep brain stimulation via a flexible PIMNT energy harvester

Hwang, Geon-Tae,Kim, Youngsoo,Lee, Jeong-Ho,Oh, SeKwon,Jeong, Chang Kyu,Park, Dae Yong,Ryu, Jungho,Kwon, HyukSang,Lee, Sang-Goo,Joung, Boyoung,Kim, Daesoo,Lee, Keon Jae The Royal Society of Chemistry 2015 ENERGY AND ENVIRONMENTAL SCIENCE Vol.8 No.9

<P>Deep brain stimulation (DBS) is widely used for neural prosthetics and brain-computer interfacing. Thus far <I>in vivo</I> implantation of a battery has been a prerequisite to supply the necessary power. Although flexible energy harvesters have recently emerged as alternatives to batteries, they generate insufficient energy for operating brain stimulation. Herein, we report a high performance flexible piezoelectric energy harvester by enabling self-powered DBS in mice. This device adopts an indium modified crystalline Pb(In1/2Nb1/2)O3-Pb(Mg1/3Nb2/3)O3-PbTiO3 (PIMNT) thin film on a plastic substrate to transform tiny mechanical motions to electricity. With slight bending, it generates an extremely high current reaching 0.57 mA, which satisfies the high threshold current for real-time DBS of the motor cortex and thereby could efficiently induce forearm movements in mice. The PIMNT based flexible energy harvester could open a new avenue for future <I>in vivo</I> healthcare technology using self-powered biomedical devices.</P>

Incremental predictive value of pre-procedural N-terminal pro-B-type natriuretic peptide for short-term recurrence in atrial fibrillation ablation

Hwang, Hye Jin,Son, Jung Woo,Nam, Byung-Ho,Joung, Boyoung,Lee, Byungho,Kim, Jin-Bae,Lee, Moon-Hyoung,Jang, Yangsoo,Chung, Namsik,Shim, Won-Heum,Cho, Seung-Yun,Kim, Sung Soon Springer-Verlag 2009 Clinical research in cardiology Vol.98 No.4

여가공간으로서 청계천의 브랜드 개성이 브랜드 태도에 미치는 영향

황혜선(Hwang, Hyeseon),김보영(Kim, Boyoung) 인제대학교 디자인연구소 2012 Journal of Integrated Design Research (JIDR) Vol.11 No.3

현대사회의 변화 속에 여가 공간 역시 그 개념과 범위가 확대되었으며, 적극적인 브랜딩과 마케팅 활동을 통한 능동적인 여가공간 활성화 방안의 논의가 필요해지고 있다. 이에 본 연구에서는 장소 마케팅적 관점에서 여가공간의 브랜드 개성이 브랜드 태도에 긍정적 영향을 미친다는 사실을 밝히고, 여가공간의 브랜드 인지와 개성의 중요함을 시사하고자 했다. 이를 위해 청계천을 연구 대상으로 선정하여 총 253명의 설문 조사를 기반으로 청개천의 브랜드 개성을 도출하고, 개성 척도에 따른 태도와의 관계성을 규명하였다. 결과적으로 현재 청계천은 ‘편안한’, ‘자연스러운’, ‘역동적인’, ‘세련된’, ‘유능한’ 의 총 5가지 브랜드 개성요인을 가지고 있는 것으로 나타났으며, 이러한 브랜드 개성이 청계천에 대한 긍정적 브랜드 태도를 형성하는 것으로 나타났다. This research is to establish the validity of brand personality and its influence on brand behavior in this context, which will help to develop more practical strategies for the leisure space brand and suggest a broaden perspective on leisure space from a marketing point of view. In order to achieve the goal, the research identified the dimensions of brand personality of Cheonggyecheon, a well-known leisure space brand, and investigated the relationship between brand personality and brand behavior by analysing the data collected from a survey conducted on 253 university students around the capital area. The findings of the study revealed that the dimensions of leisure space brand personality have been classified as peacefulness, naturalness, excitement, sophistication and competence and that brand personality has a positive effect on the brand behavior. In addition, except "sophistication", the others among the brand personality factors have a positive effect on the brand behavior such as a perceived quality, satisfaction and intention to revisit and to recommend. Furthermore, the relative importance of brand personality on brand behavior was found to be different according to the dimensions.

영주 사과와 상주 곶감의 지리적 표시제 특성에 대한 연구

황윤영(Hwang, Yoonyoung),이보영(Lee, Boyoung) 한국지역지리학회 2018 한국지역지리학회지 Vol.24 No.1

이 연구의 목적은 영주 사과와 상주 곶감을 대상으로 등록된 지리적 표시제와 현재 운영 중인 지리적 표시제의 특성을 확인하며, 지리적 표시제의 운영상의 문제를 분석하고 개선 방안을 도출하고자 한다. 지리적 표시제의 가장 큰 문제는 등록된 법인이 대표성과 정당성을 결여하고 있으며, 지리적 표시제 등록 제품의 생산과 품질관리에서 어려움을 겪고 있는 것으로 밝혀졌다. 비록 영주시와 상주시가 판매와 마케팅에 예산을 투입했음에도 불구하고 제품 판매는 크게 증가하지 않았으며 지리적 표시제의 시행에 있어서 연계성의 부족으로 분산적이며 중복되어 진행되고 있다. 이에 근거하여 중앙 정부, 지방 자치 단체, 등록 법인 등 운영 주체별로 개선 방안을 모색하였다. The purpose of this research is to identify registered Geographical Indication(GI) System and operating GI System for Youngju apple and Sangju dried persimmon, and to seek ways to improve based on the identified problems from operating GI System. We found following problems of GI System from the research. The biggest problem of GI System is that registered corporations lack representativeness and legitimacy, and it appears that they are commonly having difficulties in production and quality management of GI-registered products. Secondly, even though Youngju and Sangju have budgeted a lot for promotion and marketing of local products annually, they have failed to promote GI-registered products. Lastly, the projects are dispersive and overlap with each other due to being lack of connectivity among the projects. Based on the problems, we suggest how to improve the problems by each operating agents such and national government, local government and registered corporations.

Attribution to Heterogeneous Risk Factors for Breast Cancer Subtypes Based on Hormone Receptor and Human Epidermal Growth Factor 2 Receptor Expression in Korea

Park, Boyoung,Choi, Ji-Yeob,Sung, Ho Kyung,Ahn, Choonghyun,Hwang, Yunji,Jang, Jieun,Lee, Juyeon,Kim, Heewon,Shin, Hai-Rim,Park, Sohee,Han, Wonshik,Noh, Dong-Young,Yoo, Keun-Young,Kang, Daehee,Park, Su Wolters Kluwer Health 2016 Medicine Vol.95 No.14

<▼1><P>Supplemental Digital Content is available in the text</P></▼1><▼2><P><B>Abstract</B></P><P>We conducted a heterogeneous risk assessment of breast cancer based on the hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) calculating the risks and population-based attributable fractions (PAFs) for modifiable and nonmodifiable factors.</P><P>Using matched case–control study design from the Seoul Breast Cancer Study and the national prevalence of exposure, the risks and PAFs for modifiable and nonmodifiable factors were estimated for total breast cancers and subtypes.</P><P>The attribution to modifiable factors was different for each subtype (luminal A, PAF = 61.4% [95% confidence interval, CI = 54.3%–69.8%]; luminal B, 21.4% [95% CI = 18.6–24.9%]; HER2-overexpression, 59.4% [95% CI = 47.8%–74.3%], and triple negative tumors [TNs], 27.1% [95% CI = 22.9%–32.4%)], and the attribution to the modifiable factors for the luminal A and HER2-overexpression subtypes was higher than that of the luminal B and TN subtypes (<I>P</I> heterogeneity ≤ 0.001). The contribution of modifiable reproductive factors to luminal A type in premenopausal women was higher than that of the other subtypes (18.2% for luminal A; 3.1%, 8.1%, and −3.1% for luminal B, HER2-overexpression, and TN subtypes, respectively; <I>P</I> heterogeneity ≤ 0.001). Physical activity had the highest impact preventing 32.6% of luminal A, 14.5% of luminal B, 38.0% of HER2-overexpression, and 26.9% of TN subtypes (<I>P</I> heterogeneity = 0.014). Total reproductive factors were also heterogeneously attributed to each breast cancer subtype (luminal A, 65.4%; luminal B, 24.1%; HER2-overexpression, 57.9%, and TN subtypes, −3.1%; <I>P</I> heterogeneity ≤ 0.001).</P><P>Each pathological subtype of breast cancer by HRs and HER2 status may be associated with heterogeneous risk factors and their attributable risk, suggesting a different etiology. The luminal B and TN subtypes seemed to be less preventable despite intervention for alleged risk factors, even though physical activity had a high preventable potential against breast cancer.</P></▼2>

Lack of Effects of Peroxisome Proliferator-Activated Receptor Gamma Genetic Polymorphisms on Breast Cancer Risk: a Case-Control Study and Pooled Analysis

Park, Boyoung,Shin, Aesun,Kim, Kyee-Zu,Lee, Yeon-Su,Hwang, Jung-Ah,Kim, Yeonju,Sung, Joohon,Yoo, Keun-Young,Lee, Eun-Sook Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.21

A growing body of evidence suggests that the peroxisome proliferator-activated receptor-gamma ($PPAR{\gamma}$) gene may harbor targets for the chemoprevention of breast cancer. However, it is unclear whether polymorphisms in the $PPAR{\gamma}$ gene are associated with the susceptibility of breast cancer. We performed a candidate gene association study between $PPAR{\gamma}$ polymorphisms and breast cancer and a meta-analysis on the association of breast cancer with selected $PPAR{\gamma}$ variants. Six single nucleotide polymorphisms (SNPs) in the $PPAR{\gamma}$ gene were analyzed among 456 breast cancer patients and 461 controls from the National Cancer Center in Korea. Association between the polymorphisms and breast cancer risk were assessed using the Cochrane-Armitage test for trend and a multivariate logistic regression model. Two SNPs, rs3856806 and rs1801282, had been previously analyzed, thus enabling us to perform pooled analyses on their associations with breast cancer susceptibility. Our findings from the candidate gene association study showed no association between the $PPAR{\gamma}$ gene polymorphisms and breast cancer risk. A meta-analysis combining existing studies and our current study also refuted an association of the $PPAR{\gamma}$ gene with breast cancer. Our findings suggest that the $PPAR{\gamma}$ gene may not harbor variants that alter breast cancer susceptibility, although a moderate sample size might have precluded a decisive conclusion.

준설 물량 산출을 위한 지반정보 3차원 가시화 프로그램 비교 평가

이보영(Boyoung Lee),황범식(Bumsik Hwang),김한샘(Han-Saem Kim),조완제(Wanjei Cho) 한국지반환경공학회 2016 한국지반환경공학회논문집 Vol.17 No.7

국내 및 해외에서 진행되고 있는 간척사업은 대규모 매립재가 필요하나 육상에서 얻을 수 있는 매립재는 한정되어 있어 해상준설토를 활용하기 위한 지반 정보화 관련 연구가 활발히 진행되고 있다. 이러한 연구의 일환으로 준설지역 지반조사 자료의 디지털 공간 정보화를 통해 신뢰도가 고려된 3차원 준설 물량의 자동 산출이 가능한 GIS 기반의 준설 매립지반 DB 구축 및 3차원 준설 매립 정보화 프로그램을 개발하였다. 현장에서 준설된 물량과의 비교 검증에 앞서 본 연구에서는 수집된 새만금 지역의 군장항 인근 지반조사 자료를 바탕으로 개발된 프로그램과 3차원 준설 매립 정보화 상용 프로그램으로 지반정보의 3차원 가시화를 수행하였다. 이를 토대로 가시화 수준, 각 지층의 단면 및 심도, 정량적 준설 물량 산출 결과를 비교하여 개발 프로그램에 대한 적정성을 평가하였으며, 평가결과 각각 산출된 준설 물량은 일치하는 것으로 나타났다. There are many reclamation projects domestically and internationally which requires large quantity of reclaimable materials. To provide enough reclaimable soils which are limited in land, there have been various research focusing on the dredged soils in the marine environments. As a part of this research, a GIS based 3D dredging reclamation visualization program was developed for the volume estimation of dredged soils in 2015. The developed program is based on the digitized spatial information of the site investigation data with a consideration of the reliability of the data. Prior to the validation with the comparisons with the actual dredged volume measurement data, the developed program was compared with the commercial 3D visualization program with 3D visualized results from the test site near the Gunjang harbor. The validation of the developed program was performed in terms of the degree of visualized precision, the sectional and profiling of soil layers and the dredged volume estimation results. Based on the comparisons, both commercial and developed program show similar dredged volume with minor discrepancies in soil layers.

3차원 지하공간통합지도 구축을 위한 지반정보 정밀도 분석

이보영(Boyoung Lee),황범식(Bumsik Hwang),조완제(Wanjei Cho) 한국지반환경공학회 2017 한국지반환경공학회논문집 Vol.18 No.4

국토해양부(현재 국토교통부)가 2000년부터 현재까지 지속적으로 추진하고 있는 국토지반정보 DB구축사업은 2015년 12월 31일을 기준으로 약 21만 공의 지반정보 DB를 국토지반정보 통합DB센터(2017)를 통하여 제공하고 있다. 2007년 시작된 지하공간정보전산화 초기 사업은 정보의 수집에 초점이 맞추어졌다면, 2013~2014년은 수집된 정보의 정밀 · 정확도를 검증하는 연구가 진행되었다. 최근 시작된 3차원 지하공간통합지도 구축 사업과 더불어 지반정보를 3차원으로 가시화하고 이 과정에서의 정밀도를 분석할 필요가 대두되었다. 따라서 본 연구에서는 시추정보 정밀도의 검증 및 향상을 위해 ArcGIS에서 제공하는 지구통계학적 기법인 크리깅 기법과 RMSE의 비교 · 분석 및 검토를 통해 체계적인 3차원 지반정보 구축을 위한 기초 자료를 제시하고자 하였다. 또한 구축된 시추정보 DB의 표고자료 및 DEM 자료를 비교・분석하여 표고 자료의 오차를 검증하였다. Since 2000, the national geotechnical information DB has been constructed by Transport and Maritime Affairs (present Ministry of Land) and recently, it provides more than 210 thousands borehole informations through the geotechnical information DB portal systems. The initial project of underground space information computerization was begun in 2007, focusing on collecting the informations after then additional studies had been conducted to verify the precision and accuracy of collected informations in 2013~ 2014. In accordance with the recent initiation of the 3D integrated underground space mapping project, it is necessary to construct 3D image of the geotechnical information and evaluate the accuracy and precision of the information. Therefore, in this research, the basic information regarding the precision of the geotechnical DB is provided by kriging method and analysis of RMSE for the systematic 3D construction of geotechnical information. In addition, the elevation data errors of boring information are verified by analysis of elevation data such as boring information data and DEM data.

이상치 분석을 통한 3차원 지반정보 정밀도 향상 방안

이보영(Boyoung Lee),황범식(Bumsik Hwang),김한샘(Hansaem Kim),조완제(Wanjei Cho) 한국지반환경공학회 2018 한국지반환경공학회논문집 Vol.19 No.2

최근 서울 및 대도심지에서는 도로함몰과 동공 같은 지반재해가 빈번히 발생되고 있다. 이에 따라 정부차원의 해결책으로 지하공간통합지도 제작에 관한 연구가 진행 중에 있다. 한편, 지하공간통합지도의 근간이 되는 지반정보는 국토지반정보 통합DB센터에 22만 공 이상의 시추공DB로 구축되어 있다. 이러한 지반정보를 토대로 3차원 지하공간통합지도를 구축하기 위해서는 지반정보의 정밀도 검증 및 평가를 통한 신뢰성 확보가 우선시된다. 이로 인해 기 구축된 지반정보 DB에 대한 정밀도 검증 및 평가에 대한 연구가 수행된 바 있으며, 최근에는 지반정보를 3차원으로 가시화하기 위한 지반정보의 정밀도 분석에 더불어 활용 방안에 대하여 검토된 바 있다. 본 연구에서는 이에 나아가 지반정보의 정밀도 향상 방안을 수립하여 선행 연구 결과를 토대로 신뢰성 있는 3차원 지하공간통합지도의 구축을 위한 지반정보의 정밀도 향상 모듈을 제시하고자 한다. Recently, ground disasters such as road collapses and cavities have been frequently occurred in Seoul and downtown areas. As a result, studies on the integrated underground space map is underway as a government’s solution. On the other hand, the geotechnical information underlying the integrated underground space map has been being built with more than 220 thousands borehole DB informations through the Integrated DB Center of National Geotechnical Information. To build a three-dimensional integrated underground space map based on the geotechnical information, the reliability of the geotechnical information should be verified by analyzing and evaluating the precision of the geotechnical information. Thereby, studies were conducted on the precision verification and evaluation of the constructed geotechnical information. Thereafter, it has been reviewed how to utilize geotechnical information in addition to analyzing the precision of the geotechnical information in order to visualize three dimensions in geotechnical information. As a further step to the practical DB application, a module is suggested in this study to improve the precision of geotechnical information for establishing reliable three dimensional integrated underground space maps based on the previous research results.

Adaptation of Sensory Nerve Afferents for Selective Elicitation of Tactile Sensations

안보영(Boyoung An),마주형(Joohyung Ma),황선희(Sun Hee Hwang),송동진(Tongjin Song),강곤(Gon Khang) Korean Society for Precision Engineering 2015 한국정밀공학회지 Vol.32 No.10