외상성 두부 손상 환자의 주관적 증상 호소 정도에 따른 다면적 인성검사와 신경심리 검사의 비교

구본훈,정은정,서완석,송창진,장혜경,배대석 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : The purpose of this study was to investigate the clinical characteristics of "fake bad" and "fake good" patients with traumatic head injury in neuropsychological tests. Methods : We measured subjective symptoms by SCL-90-R and objective symptoms by McBride obstacle-valuation measure. The patient was divided into three groups according to differences between subjective and objective symptoms. We also examined their intelligence, memory, clinical characteristics, using K-WAIS, K-MAS, MMPI. Results : The group who overly expressed their subjective symptoms has its psychotic symptom exaggeratingly measured, so it will be helpful to be careful to such over-expressed symptoms in those who present a psychotic symptom in a clinical Viewpoint. An K-WAIS measurement among those who exaggerated their subjective symptoms showed less value than the actual one, which weakens the reliability of this intelligent test. Rather, for that grouP, the result of K-MAS can be used with a confidence in the estimation of their severity of symptoms. Conclusion : MMPI and neuropsychological tests are helpful to understand characteristics between subjective symptoms and objective disabilities of patients with traumatic head injury.

CaO, Ca(OH)₂-C₂H??OH-CO₂계에서 탄산칼슘 미분말의 합성

민경소,구본급 大田工業大學 1992 한밭대학교 논문집 Vol.9 No.1

Calcium carbonate fine powders were synthesized in the system CaO-Ca(OH)_2 -C_2H_5OH -CO_2 and the properties of powders obtained were examined for each syn- thetic condition. When ethanol was used as a solvent, reaction did not occured. Because CaO and Ca(OH)_2 were insoluble in ethanol. Adding ethylene glycol in ethanol, spherical powders with the average size of submicron were obtained, and crystal phase of powders was vaterite. The addition of ethylene glycol have an effect above 10 vol%. The vaterite phase powders synthesized in this experiments have been showed lower decomposition temperature and have been transfered calcite having the shapes of the starting particles.

쥐의 망막 미세구조에 미치는 급성 메탄올 중독에 대한 에탄올의 효과 관찰

이호경,유진형,구본술 인제대학교 1983 仁濟醫學 Vol.4 No.3

복강내 메탄올 주입으로 급성 메탄올 중독을 일으킨 쥐와 메탄올 주입 직후, 8시간 후 및 24시간 후에 에탄올을 투여한 쥐의 망막 미세구조를 관찰하여, 메탄올 주입 직후와 8시간 후에 에탄올을 투여한 쥐에서 메탄올에 의한 망막 조직 파괴가 경감되었음을 관찰하였다. Methanol is a widely-used chemical which can cause serious visual loss by accidental ingestion, and ethanol therapy has been considered effective in maintaining life as well as preserving vision, if performed appropriately. To provide histopathologic basis of ethanol therapy in acute methanol poisoning, which is still obscure, methanol was injected intraperitoneally to the rat and ethanol therapy was carried out immediately after, 8 hours after, and 24 hours after methanol injection. One month later, specimens of retina were obtained and examined using electron microscope, comparing with only methanol-injected case. The results were as follows. 1.Ultrastructural examination of retina of the only methanol·injected rat revealed such histologic changes as retinal ganglion cell degeneration, vacuole formation in nerve fiber layer, photoreceptor outer segment destruction, and separation of inter-pigment epithelial junction, which are compatible with clinically observed visual deterioration. 2.Retinal changes were much reduced in the rat which had received ethanol therapy immediately after methanol injection, but the reduction was not conspicuous in the 8 hour-interval ethanol treated rat. No differences were found between only methanol-injected rat and 24 hour-interval ethanol-treated case.

복귀돌연변이시험을 이용한 이온화에너지 처리 우유 및 아이스크림의 유전독성학적 평가

유지숙, 한선경, 신명수, 구본철, 최지현, 이주운, 조철훈, 함준상, 이완규 충북대학교 동물의학연구소 2008 Journal of Biomedical and Translational Research Vol.9 No.1

본문참고

Pulse Oximeter를 이용한 치수생활력측정

이제호,구본경,이종갑 大韓小兒齒科學會 2000 大韓小兒齒科學會誌 Vol.27 No.1

치수 생활력 검사시 전통적인 방법으로 전기치수검사나 온도변화검사 등이 있다. EPT와 ice test 즉, 전기치수검사와 온도변화검사는 치아의 신경학적 반응에 의해 치아의 실활여부를 판단하는 방법으로 환자가 아동일 때는 정확한 반응을 얻기가 어렵고, 환자의 주관적 반응을 판단해야 하므로 객관적이지 못하고, 소아환자에게 좋지 못한 자극을 주어 행동 조절의 문제를 일으키며, 거짓 양성반응과 거짓 음성반응이 나올 수 있다는 등의 한계가 있다. 최근에는 전통적인 방법의 한계를 극복하려는 시도에서 혈관의 보전성을 평가하는 방법인 laser doppler flowmetry와 pulse oximeter를 이용하는 방법이 소개되고 있다. Pulse oximeter의 원리는 두 가지 종류의 파장의 빛을 귀, 손가락 등 생체의 말단에 투과시켜 발산된 빛과 감지된 빛간의 두 파장의 흡수비로 산소포화 정도를 알아내는 것으로서 이에 착안하여 또 하나의 생체 말단인 치아에 이를 적용하여 치아의 실활 여부를 판단하는 것이다. 이 보고에서는 치수 생활력 검사시 pulse oximeter의 사용 가능성에 대해 검증하고 이의 임상적용에 대해 기초적 자료를 제공하고자 함을 목적으로 했는데 생활치에서는 평균 96.3%의 산소 포화도를 실활치에서는 평균 0.0%의 산소 포화도를 얻어냄으로서 pulse oximeter가 치아의 실활여부 판단에 있어 유용한 진단도구로서의 가치가 있다는 것이 밝혀졌다. Traditionally, EPT and thermal tests were used as diagnostic methods for pulp vitality test. The thermal and electrical stimulation tests are the methods to determine the vitality of a tooth based on its neuronal response. These have certain limitations, one of them is the difficulty of approaching the correct result in case of treatment of children. The reason is management problem caused by the unpleasant stimulation. Also, the response from patients are not objective, and false positive or false negative could be happened. Recently, laser doppler flowmetry and pulse oximeter which evaluate vascular integrity are introduced-in an effort of overcoming to limitation of traditional methods. The principle of pulse oximeter is to find out level of oxygen saturation by ratio of the two pulses between emitted light and detected light penetrating them to the termination of body, such as ears or fingers. From this point of view, it can be applied to a tooth to determine its vitality. The objective of this study lies mainly on varifying pulse oximeter as a method of determining tooth vitality and providing basic data of its clinical implementation. The result of the research showed that level of oxygen saturation in vital teeth was average of 96.3% and 0.0% in pulpless teeth. As a comprehensive result, pulse oximeter could be an useful diagnostic equipment in determining of tooth vitality.

이온화에너지 처리 아이스크림 및 우유의 단회투여 독성시험

이희준,최현종,한선경,구본철,신명수,함준상,조철훈,이완규 충북대학교 동물의학연구소 2006 Journal of Biomedical and Translational Research Vol.7 No.1

본문참조

Analysis of Research Papers Published in the Korean Journal of Clinical Laboratory Science from 1985 to 2012

( Bon Kyung Koo ) 대한임상검사과학회 2013 대한임상검사과학회지(KJCLS) Vol.45 No.4

The author surveyed and analyzed the research papers of korean journal of clinical laboratory science (KJCLS) that have been posted for 28 years from 17 volumes in 1985 to 44 volumes in 2012 in the time of 50th anniversary of foundation of the korean association of medical technologists (KAMT) of in 2012. This study is aimed to provide members with basic materials helpful to research development and suggest development measures of journal. The author analyzed the number of papers, research field, type of papers, and number of authors based on the title of paper. The total number of papers is 916 and average number of paper is 33. The research field was biochemistry 167 (18.2%), microbiology 160 (17.4%), histology & cytology 99 (10.8%), molecular genetics 77 (8.5%), hematology 69 (7.5%), physiologic function 64 (7.0%), immunology 60 (6.5%), blood bank 33 (3.6%), radioimmunoassay 33 (3.6%), parasitology 27 (2.9%), quality control 18 (2.0%), urinalysis & body fluid 13 (1.4%), cytogenetics 12 (1.3%), flow cytometry analysis 6 (0.7%), and other articles were 78 (8.5%). Regarding the type of papers, original article was 777 (84.8%), case report 52 (5.7%), review 23 (2.5%), others 64 (7.0%). Regarding the number of paper authors, single author was 208 (22.7%), 2-man joint authors 178 (19.4%), 3-man joint authors 181 (19.8%), 4-man joint authors 151 (16.5%), over-5-man joint authors 198 (21.6%). The average number of papers was 33 for 28 years from 1985 to 2012, it is fewer than number of technologists and professors working currently regardless of the level of quantity and quality. The KAMT needs paper promoting measures and strategic investment on the scholarly journals that can aggressively promote to members and inspire research desire for korea citation index (KCI) registered article selection of KJCLS in the future.

Comparison of Two Methods for Heparin Sensitivity; Activated Partial Thromboplastin Time Assay using in vitro Heparin-spiked Sample and Anti-Xa Assay using in vivo Heparin-treated Sample

( Bon-kyung Koo ),( Eui-hoon Kwon ),( Kwang-hyun Ryu ),( Jae-won Yun ),( Hee-jin Kim ) 대한임상검사과학회 2011 대한임상검사과학회지(KJCLS) Vol.43 No.4

The monitoring of heparin therapy is using almost aPTT assay. This study is compare to estimating aPTT therapeutic range using in vitro heparin-spiked sample and aPTT therapeutic range using in vivo heparin-treated sample. Normal pooled plasma was collected from 20 healthy representative individuals. 11 concentration of heparinized plasmas from 0 U/mL to 1.0 U/mL at intervals of 0.1 U/mL made by addition of heparin to normal pooled plasma were measured aPTT. The aPTT therapeutic range was performed through correlation analysis between heparin level 0.2 to 0.4 U/mL and aPTT. 30 plasmas from patients on heparin therapy were measured aPTT and anti-Xa activity. The aPTT therapeutic range was performed through correlation analysis between anti-Xa activity 0.3 to 0.7 U/mL and aPTT. The aPTT therapeutic range corresponded by heparin level-vs-aPTT value regression analysis was 60.7 to 102.4 seconds. The aPTT therapeutic range corresponded by anti-Xa activity-vs-aPTT value regression analysis was 85.3 to 147.5 seconds. The validation of heparin sensitivity using in-vitro heparin sample was not considered. The establishing aPTT therapeutic range is recommended anti-Xa activity using in-vivo sample.

Poster Session 1 : Structural basis of syndecan-4 phosphorylation as a molecular switch to regulate signaling

( Bon Kyung Koo ),( Joon Shin ),( Seung In Kim ),( In Noc Han ),( Eok Soo Oh ),( Weon Tae Lee ) 한국생화학분자생물학회 (구 한국생화학회) 2005 생화학분자생물학회 춘계학술발표논문집 Vol.2005 No.-

Test turnaround Time for Complete Blood Cell Count using Delta and Panic Value Checks and the Q-flag Limit

( Bon-kyung Koo ),( Kwang-hyun Ryu ),( Dae-jin Lim ),( Young-kuk Cho ),( Hee-jin Kim ) 대한임상검사과학회 2012 대한임상검사과학회지(KJCLS) Vol.44 No.2

Test turnaround time (TAT) is the lead time from reception to reporting. In the complete blood cell count (CBC), 4 units of the XE-2100 (Sysmex Corp., Japan) processed around 80% of quantity, 1 unit of the LH-780 (Beckman-Coulter Incorp., USA) processed around 10% and 1 unit of ADVIA-2120 (Siemens AG, Munich, Germany) processed around 10%. We analyzed the change in the TAT for the CBC for over 7 years, from January of 2005 to December of 2011. The delta check made alterations of delta to WBC, hemoglobin, hematocrit, platelet and metamyelocyte, however, did not made them to band neutrophil, eosinophil, basophil and monocyte. The panic value check made alterations of panic value to hemoglobin, hematocrit, platelet and monocyte. In the criteria of currently slide review, LH-780 and ADVI-2120 analyzers prepared suspect flags of “Blast, Imm NE2, Immature granulocyte, Imm NE1, Left shift, Variant lymphocyte, Atypical lymphocyte, Platelet clumps and NRBC”. The New slide review in the XE-2100 analyzer altered the preparations of a smear slide more than a “Platelet clumps flag(≥200 unit), a single flag excluding the “Platelet clumps flag (≥250 unit) and a multiple flag (≥200 unit)”. Also, below the 240 unit, medical technologists prepared manual slides selectively according to their evaluations. The automatic reporting rate was 33.4% without alterations, whereas it was 41.0% without alterations, and was thus improved by 7.6%. The slide review rate was 15.2% before using the Q-flag limit, whereas it was 12.1% for a reduce 3.1%. TAT was 45 minutes without the creation alterations of the delta and panic value checks, whereas it was 35 minutes after making alterations of the delta and panic value checks and thus was shortened by 10 minutes. We came to the conclusion that the establishment and operation of delta and panic value checks and slide review criteria suitable for laboratory environment can reduce unnecessary smear slides, re-checking, re-sampling, re-testing, telephone inquiries and concentrated workloads during specific times of the day.