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RISS 인기검색어
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- 저자 : Bohee Hong (검색결과 5 건)
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Jang, Bohee,Jung, Hyejung,Hong, Heejeong,Oh, Eok-Soo Elsevier 2018 Cellular signalling Vol.52 No.-
<P><B>Abstract</B></P> <P>Cell surface receptors must specifically recognize an extracellular ligand and then trigger an appropriate response within the cell. Their general structure enables this, as it comprises an extracellular domain that can bind an extracellular ligand, a cytoplasmic domain that can transduce a signal inside the cell to produce an appropriate response, and a transmembrane domain that links the two and is responsible for accurately delivering specific information on a binding event from the extracellular domain to the cytoplasmic domain, to trigger the proper response. A vast body of research has focused on elucidating the specific mechanisms responsible for regulating extracellular binding events and the subsequent interactions of the cytoplasmic domain with intracellular signaling. In contrast, far less work has focused on examining how the transmembrane domain links these domains and delivers the necessary information. In this review, we propose the importance of the transmembrane domain as a signal regulator. We highlight the cell adhesion receptor, syndecan, as a special case, and propose that the transmembrane domain-mediated oligomerization of the syndecan cytoplasmic domain is a unique regulatory mechanism in syndecan signaling.</P>
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Kim, Mihye,Hong, Bohee,Lee, Jongman,Kim, Se Eun,Kang, Seong Soo,Kim, Young Ha,Tae, Giyoong American Chemical Society 2012 Biomacromolecules Vol.13 No.8
<P>Delivering isolated chondrocytes with matrix is a promising approach to promote the cartilage repair. The present study attempted to combine the advantages of porous scaffold and hydrogel in delivering chondrocytes to partial-thickness cartilage defects. An electrospun, gelatin-incorporated PLCL scaffold mechanically similar to natural cartilage was fabricated, and chondrocytes were seeded using an injectable heparin-based hydrogel for efficient cell seeding. The scaffold/hydrogel composite showed more enhanced expression of chondrogenic genes and production of GAGs than those prepared without hydrogel. In addition, significant cartilage formation showing good integration with surrounding, similar to natural cartilage, was observed by scaffold/hydrogel composite system in partial-thickness defects of rabbit knees while no regeneration was observed in control defects. Although no exogenous chondrogenic factors were added, it was evident that the scaffold/hydrogel composite system was highly effective and better than the scaffold alone system without hydrogel for cartilage regeneration both in vitro and in vivo.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bomaf6/2012/bomaf6.2012.13.issue-8/bm3005353/production/images/medium/bm-2012-005353_0011.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/bm3005353'>ACS Electronic Supporting Info</A></P>
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문화중심형 공공디자인의 전략 기획을 위한 관련지표 분석
이정민(Jeongmin Lee),홍의택(Euitaek Hong),이한나(Hanna Lee),정보희(Bohee Jung) 한국콘텐츠학회 2011 한국콘텐츠학회논문지 Vol.11 No.9
21세기는 문화패러다임의 시대이며 시민들의 문화적 수요를 반영하는 공공환경 정책을 필요로 하고 있다. 이런 요구를 충족시키기 위해 지역자원을 바탕으로 한 문화중심형 공공디자인의 개발이 관심을 끌고 있다. 본 연구는 문화중심형 공공디자인 사업의 기획을 위한 전략 프로그래밍 지원모델을 개발하고자 하는 목적으로 시행되었다. 이 모델을 추상적인 개념들로 이루어진 프로세스 모델이 아니라 선택형 참조체계 방식의 모델로 개발하기 위하여 본고에서는 전략프로그래밍 프로토타입 단계별 관련지표들을 분석하였다. 프로토타입 단계들 중에서 특히 장소전략 수립단계(리소스, 미션, 타겟팅)에 초점을 맞추어 관련지표들을 분석하였다. 정성적 사례분석을 통해 연관요소들을 추출하였고 이에서 공통점을 분석하여 단계별 관련지표로 설정하였다. 모두 81개의 지표가 분석되었다. Citizens of 21st century which is called to be the era of 'Culture' express their cultural desires in their public environments. Governments found that these needs can be satisfied through the culture-centered public designs which are based on the local resources and identities. This research suggests the strategy programming model to support these projects. It aims at not suggesting the conceptual process model, but developing the practical supporting model with options to choose. Thus the indices which are related to each prototype phases of programming process are analyzed through the case analyses with qualitative approach. This paper focused on analyzing the indices for Place Strategy which includes the phases for Resource, Mission, and Targeting. Altogether, 81 indices are analyzed.
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Sherlyn C. Tipayno,Puneet S. Chauhan,Sungman Woo,Bohee Hong,Keewoong Park,Jongbae Chung,Tongmin Sa 한국토양비료학회 2011 한국토양비료학회지 Vol.44 No.1
The continuous increase in the production of metals and their subsequent release into the environment has lead to increased concentration of these elements in agricultural soils. Because microbes are involved in almost every chemical transformations taking place in the soil, considerable attention has been given to assessing their responses to metal contaminants. Short-term and long-term exposures to toxic metals have been shown to reduce microbial diversity, biomass and activities in the soil. Several studies show that microbial parameters like basal respiration, metabolic quotient, and enzymatic activities, including those of oxidoreductases and those involved in the cycle of C, N, P and other elements, exhibit sensitivity to soil metal concentrations. These have been therefore, regarded as good indices for assessing the impact of metal contaminants to the soil. Metal contamination has also been extensively shown to decrease species diversity and cause shifts in microbial community structure. Biochemical and molecular techniques that are currently being employed to detect these changes are continuously challenged by several limiting factors, although showing some degree of sensitivity and efficiency. Variations and inconsistencies in the responses of bioindicators to metal stress in the soil can also be explained by differences in bioavailability of the metal to the microorganisms. This, in turn, is influenced by soil characteristics such as CEC, pH, soil particles and other factors. Therefore, aside from selecting the appropriate techniques to better understand microbial responses to metals, it is also important to understand the prevalent environmental conditions that interplay to bring about observed changes in any given soil parameter.
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