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Hu, Liu,Wu, Qin-Qin,Wang, Wen-Bo,Jiang, Huan-Gang,Yang, Lei,Liu, Yu,Yu, Hai-Jun,Xie, Cong-Hua,Zhou, Yun-Feng,Zhou, Fu-Xiang Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.2
Ku70/80 heterodimer is a central element in the nonhomologous end joining (NHEJ) DNA repair pathway, Ku80 playing a key role in regulating the multiple functions of Ku proteins. It has been found that the Ku80 protein located at telomeres is a major contributor to radiosensitivity in some telomerase positive human cancer cells. However, in ALT human osteosarcoma cells, the precise function in radiosensitivity and telomere maintenance is still unknown. The aim of this study was to investigate the effects of Ku80 depletion in the U2OS ALT cell line cell line. Suppression of Ku80 expression was performed using a vector-based shRNA and stable Ku80 knockdown in cells was verified by Western blotting. U2OS cells treated with shRNA-Ku80 showed lower radiobiological parameters (D0, Dq and SF2) in clonogenic assays. Furthermore, shRNA-Ku80 vector transfected cells displayed shortening of the telomere length and showed less expression of TRF2 protein. These results demonstrated that down-regulation of Ku80 can sensitize ALT cells U2OS to radiation, and this radiosensitization is related to telomere length shortening.
Granular Effects on Depositional Processes of Debris Avalanches
Yu-xiang Hu,Hai-bo Li,Shun-chao Qi,Gang Fan,Jia-wen Zhou 대한토목학회 2020 KSCE JOURNAL OF CIVIL ENGINEERING Vol.24 No.4
Debris avalanches generally have massive mobility and extensive deposited area, which have strong relation to the granular effect. The granular effect is an outcome from the interaction (based on frictional mechanism) among particles. Discrepancy of grain composition, for instance the difference of particle size and their proportion of particles, is a key factor to influence granular effect. A series of laboratory tests have been conducted to research the granular effects on depositional processes of debris avalanches containing fine- and coarse-grained particles. The velocity of debris front, the morphology characteristics and runout distance of the debris avalanche are considered in detail, and the mass parameter and the size parameter are introduced in analysis for the research of granular effect. The experimental results indicate that the granular effects can decrease the dissipation of momentum and increase the accumulation region, leading to further runout distance and more extensive deposited areas. Further, the velocity, the range of depositions of debris avalanches are larger than that in other conditions when the proportion of fine-grained particles is 30%, especially the materials consist of heterogeneous granular. It means there have a critical mass parameter in experiments which lead to the high efficiency of granular effects, and the granular effect is weakening in homogeneous granular composition.
Hu, Guang,Hu, Huasi,Yang, Quanzhan,Yu, Bo,Sun, Weiqiang Korean Nuclear Society 2020 Nuclear Engineering and Technology Vol.52 No.1
The traditional methods for radiation shield design always only focus on either the structure or the components of the shields rather than both of them at the same time, which largely affects the shielding performance of the facilities, so in this paper, a novel method for designing the structure and components of shields simultaneously is put forward to enhance the shielding ability. The method is developed by using the genetic algorithm (GA) and the MCNP software. In the research, six types of shielding materials with different combinations of elements such as polyethylene (PE), lead (Pb) and Boron compounds are applied to the radiation shield design, and the performance of each material is analyzed and compared. Then two typical materials are selected based on the experiment result of the six samples, which are later verified by the Compact Accelerator Neutron Source (CANS) facility. By using this method, the optimal result can be reached rapidly, and since the design progress is semi-automatic for most procedures are completed by computer, the method saves time and improves accuracy.
Comparative Study of Ultimate Bond Strength Models for FRP-to-Steel Bonded Joints
Bo Hu,Yu-Tian Jiang 한국강구조학회 2019 International Journal of Steel Structures Vol.19 No.6
This paper presents a comparative study of current ultimate bond strength models for fi ber reinforced polymer (FRP)-tosteel bonded joints. A database that includes the test results of 106 single and 93 double lap joints was assembled from the open literature for this comparison. Comparative results show that Xia and Teng’s and Hart-Smith’s models have the highest accuracy for predicting the ultimate bond strengths of single and double lap joints, respectively. Current ultimate bond strength models for single or double lap joints have some applicability to both single and double lap joints. Xia and Teng’s model has the best performance for predicting the ultimate bond strengths of both single and double lap joints. However, the predictions by Xia and Teng’s model have a large deviation for double lap joints and for joints whose adhesives have trilinear bond–slip behavior. Based on comparative results, an improved ultimate bond strength model for both single and double lap joints is proposed. The proposed model further considers the eff ects of the joint type, the stiff ness ratio of the double lap joint and the bond–slip behavior of the adhesive. The comparison between model predictions and test results indicates that the improved model is more accurate and applicable than current models for both single and double lap joints.
Yu-Sheng Liu,Qing-Hua Lu,Xiao-Bo Hu,Hong-Zhuan Li,Wei-Dong Jiang,Xin Wang,Hao Lin,Ai-Qiong Qin,Yong-Mei Wang,Tong Zhao,Zhao-Qiang Dong,Mei Zhang 연세대학교의과대학 2011 Yonsei medical journal Vol.52 No.6
Purpose: Lipoprotein-associated phospholipase A2 (Lp-PLA_2) is an inflammatory enzyme expressed in atherosclerotic plaques. We investigated the association of circulating Lp-PLA_2 with characteristics of vulnerable coronary atherosclerotic plaques. Materials and Methods: We recruited 113 patients with either unstable angina (UA, n=59) and stable angina (SA, n=54) by coronary angiography. Thirty-six healthy subjects served as controls. Intravascular ultrasound (IVUS) was used to evaluate the characteristics of coronary atherosclerotic plaque, and serum Lp-PLA2 concentration was measured as well. Results: Lp-PLA_2 concentration was significantly higher in both UA and SA patients [(396±36) μg/L and (321±39) μg/L, respectively]compared with the controls [(127±49) μg/L, p<0.01], and higher in UA than SA group. IVUS findings showed that remodeling index (RI) (0.91±0.15 vs. 0.85±0.11, p=0.005) and eccentricity index (EI) (0.73±0.16 vs. 0.65±0.22, p=0.039) were larger in UA than in SA group, and fibrous caps were thicker in SA than UA group [(0.91±0.23) mm vs. (0.63±0.21) mm, p=0.032]. Moreover, Lp-PLA_2 correlated positively with EI (r=0.439, p<0.01) and RI (r=0.592, p<0.05) in UA group. There was an inverse relationship between Lp-PLA_2 and fibrous cap thickness in both UA (r=-0.587, p<0.001) and SA (r=-0.318, p<0.05) groups. The independent risk factors in UA group were Lp-PLA_2 (OR=1.055, 95% CI: 1.03-1.08, p=0.013), LDL-cholesterol (OR=0.032, 95% CI: 0.00-0.05, p=0.041) and fibrous cap thickness (OR=0.008, 95% CI: 0.00-0.45, p=0.019). Lp-PLA_2 was strongly associated with both EI and fibrous cap thickness in both groups. Conclusion: Serum level of Lp-PLA_2 is associated with both eccentricity index and fibrous cap thickness in both UA and SA groups. Elevated levels of circulating Lp-PLA_2 might to be a strong risk factor and more serious for unstable angina than stable angina.
Yu-Jia Lin,Hsiao-Ting Chang,Ming-Hwai Lin,Ru-Yih Chen,Ping-Jen Chen,Wen-Yuan Lin,Jyh-Gang Hsieh,Ying-Wei Wang,Chung-Chieh Hu,Yi-Sheng Liou,Tai-Yuan Chiu,Chun-Yi Tu,Yi-Jen Wang,Bo-Ren Cheng,Tzeng-Ji Ch 한국한의학연구원 2021 Integrative Medicine Research Vol.10 No.2
Background: Medical staff may have difficulties in using conventional medicine to manage symptoms among terminally ill patients, including adverse effects of the treatment. Traditional Chinese medicine (TCM) is regarded as a complementary or alternative medicine, and has been increasingly used in the field of palliative medicine in recent years. This study aimed to investigate the experiences of and attitudes toward using TCM among palliative care professionals, and to provide preliminary information about its use in palliative care. Methods: This was a cross-sectional survey study conducted in eight inpatient hospice wards in Taiwan between December 2014 and February 2016. The questionnaire was self-administered, and was analyzed with descriptive statistics including Pearson’s Chi-square test and Fisher’s exact test. Results: A total of 251 palliative care professionals responded to the questionnaire, of whom 89.7% and 88.9% believed that the use of TCM could improve the physical symptoms and quality of life in terminally ill patients, respectively. Overall, 59.8%, of respondents suggested that TCM had rare side effects, and 58.2% were worried that TCM could affect the liver and kidney function of patients. In total, 89.7% and 88.0% of professionals agreed there were no suitable clinical practice guidelines and educational programs, respectively, for TCM use in palliative care. Conclusions: Most of the respondents agreed there was insufficient knowledge, skills-training, and continuing education on the use of TCM in terminally ill patients in Taiwan. These results show that to address patient safety considerations, guidelines about use of TCM in palliative care should be established.
Kinematics and dynamic analysis of a novel hybrid dynamics simulator
Bo Hu,Liandong Zhang,Jingjing Yu 대한기계학회 2016 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.30 No.11
A serial-parallel dynamics simulator based on serial-parallel manipulator is proposed. According to the dynamics simulator motion requirement, the proposed serial-parallel dynamics simulator formed by 3-RRS (active revolute joint-revolute joint-spherical joint) and 3-SPR (Spherical joint-active prismatic joint- revolute joint) PMs adopts the outer and inner layout. By integrating the kinematics, constraint and coupling information of the 3-RRS and 3-SPR PMs into the serial-parallel manipulator, the inverse Jacobian matrix, velocity, and acceleration of the serial-parallel dynamics simulator are studied. Based on the principle of virtual work and the kinematics model, the inverse dynamic model is established. Finally, the workspace of the (3-RRS)+(3-SPR) dynamics simulator is constructed.