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RISS 인기검색어
- 검색키워드
- 저자 : Beyaz, Semir (검색결과 14 건)
- 무료
- 기관 내 무료
- 유료
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Beyaz, Serbulent Gokhan The Korean Pain Society 2011 The Korean Journal of Pain Vol.24 No.1
Background: Circumcision is a painful intervention frequently performed in pediatric surgery. We aim to compare the efficacy of caudal block versus dorsal penile block (DPNB) under general anesthesia for children undergoing circumcision. Methods: This study was performed between July 1, 2009 and October 16, 2009. Fifty male children American Society of Anesthesiolgists physical status classification I, aged between 3 and 12 were included in this randomized, prospective, comparative study. Anesthetic techniques were standardized for all children. Patients were randomized into 2 groups. Using 0.25% 0.5 ml/kg levobupivacain, we performed DPNB for Group 1 and caudal block for Group 2. Postoperative analgesia was evaluated for six hours with the Flacc Pain Scale for five categories; (F) Face, (L) Legs, (A) Activity, (C) Cry, and (C) Consolability. For every child, supplemental analgesic amounts, times, and probable local or systemic complications were recorded. Results: No significant difference between the groups (P > 0.05) was found in mean age, body weight, anesthesia duration, FLACC pain, and sedation scores (P > 0.05). However, on subsequent measurements, a significant decrease of pain and sedation scores was noted in both the DPNB group and the caudal block group (P < 0.001). No major complication was found when using either technique. Conclusions: DPNB and caudal block provided similar postoperative analgesic effects without major complications for children under general anesthesia.
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Beyaz, Semir,Kim, Ji Hyung,Pinello, Luca,Xifaras, Michael E,Hu, Yu,Huang, Jialiang,Kerenyi, Marc A,Das, Partha P,Barnitz, R Anthony,Herault, Aurelie,Dogum, Rizkullah,Haining, W Nicholas,Yilmaz, Ö NATURE AMERICA INC 2017 NATURE IMMUNOLOGY Vol.18 No.2
Invariant natural killer T cells (iNKT cells) are innate-like lymphocytes that protect against infection, autoimmune disease and cancer. However, little is known about the epigenetic regulation of iNKT cell development. Here we found that the H3K27me3 histone demethylase UTX was an essential cell-intrinsic factor that controlled an iNKT-cell lineage-specific gene-expression program and epigenetic landscape in a demethylase-activity-dependent manner. UTX-deficient iNKT cells exhibited impaired expression of iNKT cell signature genes due to a decrease in activation-associated H3K4me3 marks and an increase in repressive H3K27me3 marks within the promoters occupied by UTX. We found that JunB regulated iNKT cell development and that the expression of genes that were targets of both JunB and the iNKT cell master transcription factor PLZF was UTX dependent. We identified iNKT cell super-enhancers and demonstrated that UTX-mediated regulation of super-enhancer accessibility was a key mechanism for commitment to the iNKT cell lineage. Our findings reveal how UTX regulates the development of iNKT cells through multiple epigenetic mechanisms.
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Beyaz, Ramazan,Darcin, E. Selcen,Aycan, Murat,Kayan, Mustafa,Yildiz, Mustafa The Korean Society of Plant Biotechnology 2016 식물생명공학회지 Vol.43 No.2
In this study, routinely used transformation method, which includes transferring explants onto co-cultivation medium after inoculating them with bacterial solution for a while, was compared with 3 different inoculation methods. In every 3 methods, hypocotyl explants excised from 7-day-old sterile flax seedlings having cotyledon leaves and no root system dried under air flow in sterile cabin for 35 min were inoculated with different volumes of bacterial solution at different inoculation periods. GV2260 line of Agrobacterium tumefaciens having 'pBIN 19' plasmid containing npt II (neomycin phosphotransferase II) gene and GUS reporter gene was used in transformation studies. After inoculation, hypocotyl segments of seedlings (0.5 cm in length) - were excised and left to co-cultivation for 2 days. Then, explants were transferred to regeneration medium supplemented with different antibiotics. The presence of npt-II and GUS genes in transformants was confirmed by PCR and GUS analysis. The highest results in all characters examined in all cultivars were obtained from the 2 inoculation method in which hypocotyls excised from seedlings inoculated with $500{\mu}l$ of bacterial solution after drying in sterile cabin for 35 min were used.
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A Case of Pneumothorax after Phrenic Nerve Block with Guidance of a Nerve Stimulator
Beyaz, Serbulent Gokhan,Tufek, Adnan,Tokgoz, Orhan,Karaman, Haktan The Korean Pain Society 2011 The Korean Journal of Pain Vol.24 No.2
Hiccups have more than 100 etiologies. The most common etiology has gastrointestinal origins, related mainly to gastric distention and gastroesophageal reflux disease. Intractable hiccups are rare but may present as a severe symptom of various diseases. Hiccups are mostly treated with non-invasive or pharmacological therapies. If these therapies fail, invasive methods should be used. Here, we present a patient on whom we performed a blockage of the phrenic nerve with the guidance of a nerve stimulator. The patient also had pneumothorax as a complication. Three hours after intervention, a tube thoracostomy was performed. One week later, the patient was cured and discharged from the hospital. In conclusion, a stimulator provides the benefit of localizing the phrenic nerve, which leads to diaphragmatic contractions. Patients with thin necks have more risk of pneumothorax during phrenic nerve location.
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Seda Beyaz,Taner Tanrisever,Hakan Kockar 한국고분자학회 2010 Macromolecular Research Vol.18 No.12
Emulsifier-free emulsion polymerization of methyl methacrylate was carried out in the presence of hydrophilic magnetite nanoparticles using a persulfate initiator. Before the magnetic nanoparticles were placed into the polymerization system, they were dispersed and stabilized electrostatically with perchloric acid in water (magnetic sol). For magnetic nanoparticles in the sol, the hydrodynamic radius and polydispersity index (PDI) measured by dynamic light scattering was 18.8 nm and PDI of 0.282, respectively. The latex sizes also were determined to be 125-223 nm with a PDI of 0.009-0.065. Magnetic measurements by vibrating sample magnetometry confirmed that the magnetite nanoparticles and magnetic poly(methyl methacrylate) nanospheres exhibited superparamagnetism with zero coercivity. The saturation magnetization of the magnetic polymeric nanospheres ranged from 0.2 to 1.19 emu/g depending on the magnetite content. The polymer chain terminations were affected by the addition of magnetite nanoparticles to the polymerization system. In addition, the magnetite that reduced the average molecular weight of the polymers obtained by gel permeation chromatography should be defined as a transfer agent.
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Ramazan Beyaz,E. Selcen Darçın,Murat Aycan,Mustafa Kayan,Mustafa Yıldız 한국식물생명공학회 2016 JOURNAL OF PLANT BIOTECHNOLOGY Vol.43 No.2
In this study, routinely used transformation method, which includes transferring explants onto co-cultivation medium after inoculating them with bacterial solution for a while, was compared with 3 different inoculation methods. In every 3 methods, hypocotyl explants excised from 7-day-old sterile flax seedlings having cotyledon leaves and no root system dried under air flow in sterile cabin for 35 min were inoculated with different volumes of bacterial solution at different inoculation periods. GV2260 line of Agrobacterium tumefaciens having ‘pBIN 19’ plasmid containing npt II (neomycin phosphotransferase II) gene and GUS reporter gene was used in transformation studies. After inoculation, hypocotyl segments of seedlings (0.5 cm in length) - were excised and left to co-cultivation for 2 days. Then, explants were transferred to regeneration medium supplemented with different antibiotics. The presence of npt-II and GUS genes in transformants was confirmed by PCR and GUS analysis. The highest results in all characters examined in all cultivars were obtained from the 2 inoculation method in which hypocotyls excised from seedlings inoculated with 500 μl of bacterial solution after drying in sterile cabin for 35 min were used.
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( Serbulent Gokhan Beyaz ) 대한통증학회 2011 The Korean Journal of Pain Vol.24 No.1
Background: Circumcision is a painful intervention frequently performed in pediatric surgery. We aim to compare the efficacy of caudal block versus dorsal penile block (DPNB) under general anesthesia for children undergoing circumcision. Methods: This study was performed between July 1, 2009 and October 16, 2009. Fifty male children American Society of Anesthesiolgists physical status classification I, aged between 3 and 12 were included in this randomized, prospective, comparative study. Anesthetic techniques were standardized for all children. Patients were randomized into 2 groups. Using 0.25% 0.5 ml/kg levobupivacain, we performed DPNB for Group 1 and caudal block for Group 2. Postoperative analgesia was evaluated for six hours with the Flacc Pain Scale for five categories; (F) Face, (L) Legs, (A) Activity, (C) Cry, and (C) Consolability. For every child, supplemental analgesic amounts, times, and probable local or systemic complications were recorded. Results: No significant difference between the groups (P>0.05) was found in mean age, body weight, anesthesia duration, FLACC pain, and sedation scores (P>0.05). However, on subsequent measurements, a significant decrease of pain and sedation scores was noted in both the DPNB group and the caudal block group (P<0.001). No major complication was found when using either technique. Conclusions: DPNB and caudal block provided similar postoperative analgesic effects without major complications for children under general anesthesia. (Korean J Pain 2011; 24: 31-35)
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Case Reports : A Case of Pneumothorax after Phrenic Nerve Block with Guidance of a Nerve Stimulator
( Serbulent Gokhan Beyaz ),( Adnan Tufek ),( Orhan Tokgoz ),( Haktan Karaman ) 대한통증학회 2011 The Korean Journal of Pain Vol.24 No.2
Hiccups have more than 100 etiologies. The most common etiology has gastrointestinal origins, related mainly to gastric distention and gastroesophageal reflux disease. Intractable hiccups are rare but may present as a severe symptom of various diseases. Hiccups are mostly treated with non-invasive or pharmacological therapies. If these therapies fail, invasive methods should be used. Here, we present a patient on whom we performed a blockage of the phrenic nerve with the guidance of a nerve stimulator. The patient also had pneumothorax as a complication. Three hours after intervention, a tube thoracostomy was performed. One week later, the patient was cured and discharged from the hospital. In conclusion, a stimulator provides the benefit of localizing the phrenic nerve, which leads to diaphragmatic contractions. Patients with thin necks have more risk of pneumothorax during phrenic nerve location. (Korean J Pain 2011; 24: 105-107)
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Serbülent Gökhan Beyaz 대한통증학회 2011 The Korean Journal of Pain Vol.24 No.1
Background:Circumcision is a painful intervention frequently performed in pediatric surgery. We aim to compare the efficacy of caudal block versus dorsal penile block (DPNB) under general anesthesia for children undergoing circumcision. Methods:This study was performed between July 1, 2009 and October 16, 2009. Fifty male children American Society of Anesthesiolgists physical status classification I, aged between 3 and 12 were included in this randomized, prospective, comparative study. Anesthetic techniques were standardized for all children. Patients were randomized into 2 groups. Using 0.25% 0.5 ml/kg levobupivacain, we performed DPNB for Group 1 and caudal block for Group 2. Postoperative analgesia was evaluated for six hours with the Flacc Pain Scale for five categories; (F) Face, (L) Legs, (A) Activity, (C) Cry, and (C) Consolability. For every child, supplemental analgesic amounts, times, and probable local or systemic complications were recorded. Results:No significant difference between the groups (P > 0.05) was found in mean age, body weight, anesthesia duration, FLACC pain, and sedation scores (P > 0.05). However, on subsequent measurements, a significant decrease of pain and sedation scores was noted in both the DPNB group and the caudal block group (P < 0.001). No major complication was found when using either technique. Conclusions:DPNB and caudal block provided similar postoperative analgesic effects without major complications for children under general anesthesia.
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