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Bala Murali Krishna Vasamsetti,In-sul Hwang,Heasun Lee,Sung-June Byun,Hyeon Yang,Sun A Ock,Hwi-Cheul Lee,Jae-Seok Woo,Keon Bong Oh 한국수정란이식학회 2018 한국수정란이식학회 학술대회 Vol.2018 No.11
In our previous studies, the cardiac xenotransplantation from an alpha-1,3-galactosyltransferase knockout pig (GT-MCP-MCP) to cynomolgus monkeys showed a mean survival of 38 days. The objective of this study is to genetically upgrade the GT-MCP-MCP pig, to further enhance membrane cofactor protein (MCP) expression and to express an endothelial specific thrombomodulin (TBM). MCP is a complement regulatory protein and TBM is a coagulation inhibitor. As the dicistronic cassette for wild-type-based MCP and TBM concurrent expressions does not show any increase of MCP, we optimized the MCP codon usage (mMCP) and substituted mMCP for MCP. When the mMCP-TBM cassette was transfected to HeLa cells, we were able to find an increased expression of MCP and endothelial cell-specific TBM expression. The cassette was then transfected into ear-skin fibroblasts isolated from one-month-old #23-4 of a GT-MCP-MCP pig, and the cell populations expressing MCP were obtained by MACS cell sorting. We performed a single cell culture of the selected cells, and obtained clones over expressing 90% MCP. The cells of a clone were used as a donor for nuclear transfer and generated GT-MCP/-MCP/mMCP/TBM pig. The transgenic pig was confirmed to be carrying the cells expressing MCP and functioning as an inhibitor against the cytotoxic effect of normal monkey serum, comparable with donor cells. Thus, we believe that the GT-MCP/-MCP/mMCP/TBM transgenic pig would be potential for the prolongation of xenograft survival in the recipients.
Building Social Work Education and the Profession in a Transition Country: Case of Nepal
Bala Raju Nikku 한국사회복지학회 2012 Asian Social Work and Policy Review Vol.6 No.3
Drawing on interviews and personal accounts of the author working in Nepal for the last 7 years,this paper discusses the evolution of social work education and challenges for its growth in Nepal,a country that is going through a series of transitions and is emerging from a recent decade-longarmed conflict. Due to a lack of formal recognition and commitment from state and non-stateactors, the future of social work in Nepal is in the hands of university-affiliated colleges and the fewsocial work graduates and educators. Their commitment, strategies, and passion are crucial to thesurvival and growth of social work in conflict-stricken, transition Nepal in South Asia.
Crafting Child-friendly Cities: Evidence from Biratnagar Sub-metropolitan City, Eastern Nepal
Bala Raju Nikku,Ruja Pokhrel 한국사회복지학회 2013 Asian Social Work and Policy Review Vol.7 No.2
Our cities are increasingly becoming the sites where children socialize, observe, and learn how societyfunctions and many local and global activities have impacted children’s health and well-being. The Child-friendly Cities initiative, launched by the United Nations Children’s Fund and theUnited Nations Human Settlements Programme in 1996, draws in diverse stakeholders to placechildren at the center of the urban agenda. Based on social work research, this article analyzes theacclaimed status of Biratnagar Sub-metropolitan city, Eastern Nepal, as a child-friendly city. Despite its efforts, the city of Biratnagar is yet to meet the required criteria to claim itself as a childfriendlycity. Further improvements by the city administration in achieving children’s participationin decision-making, child-friendly legal environment, and code of conduct are essential. Based onthe evidence, the authors advocate for bottom-up approaches that include children’s voices andtheir real participation in city governance and a strong political will to craft child-friendly cities,not as a policy rhetoric but for real. Enabling children to fulfill their potential as equal participantsin crafting child-friendly cities will require adults to relinquish some of their hegemonic powers ofdecision-making on behalf of children.
Interband optical properties in wide band gap group-III nitride quantum dots
Bala, K. Jaya,Peter, A. John Techno-Press 2015 Advances in nano research Vol.3 No.1
Size dependent emission properties and the interband optical transition energies in group-III nitride based quantum dots are investigated taking into account the geometrical confinement. Exciton binding energy and the optical transition energy in $Ga_{0.9}In_{0.1}N$/GaN and $Al_{0.395}In_{0.605}N$/AlN quantum dots are studied. The largest intersubband transition energies of electron and heavy hole with the consideration of geometrical confinement are brought out. The interband optical transition energies in the quantum dots are studied. The exciton oscillator strength as a function of dot radius in the quantum dots is computed. The interband optical absorption coefficients in GaInN/GaN and AlInN/AlN quantum dots, for the constant radius, are investigated. The result shows that the largest intersubband energy of 41% (10%) enhancement has been observed when the size of the dot radius is reduced from $50{\AA}$ to $25{\AA}$ of $Ga_{0.9}In_{0.1}N$/GaN ($Al_{0.395}In_{0.605}N$/AlN) quantum dot.
Observation ofX(3872)inB→X(3872)Kπdecays
Bala, A.,Bhardwaj, V.,Trabelsi, K.,Singh, J. B.,Abdesselam, A.,Adachi, I.,Aihara, H.,Arinstein, K.,Asner, D. M.,Aulchenko, V.,Aushev, T.,Ayad, R.,Aziz, T.,Bahinipati, S.,Bakich, A. M.,Bansal, V.,Barbe American Physical Society 2015 PHYSICAL REVIEW D - Vol.91 No.5