진행성 비소세포폐암의 이차항암화학요법으로서 Docetaxel 단독요법의 성적

강현모,이정은,장필순,이연선,권선중,안진영,정성수,김주옥,김선영 충남대학교 암연구소 2006 암연구소 업적집 Vol.5 No.-

Background : The survival benefit associated with first-line chemotherapy in lung cancer has led to the need for second -line chemotherapy, for which Docetaxel (Taxotere^(?)) has proven efficacy in both settings. This study evaluated the safety and efficacy of docetaxel in patients with non-small cell lung cancer who had failed first-line platinum-based chemotherapy. Methods : Thirty one patients with non-small-cell lung cancer, who had failed first line platinum-based chemotherapy, between March 1999 and August 2003, were enrolled in this study. Patients received intravenous docetaxel, either 75 mg/㎡ or 100 mg/㎡, with routine premedication every three weeks. Results : Fourteen patients (45.2%) had a partial response. The median survival and progression- free survival times were 12.5 months (95% CI 7.3-17.6) and 3.0 months (95% CI 1.6-4.5), respectively. This study showed 2 factors gave different survival benefits; the age (< 60 years: 20.1 months vs. > 60 years: 6.6 months, p=0.0105) and the histological type (adenocarcinoma: 25.6 months vs. others: 7.9 months, p=0.0055). The predominant toxicity was neutropenia, which occurred as WHO grade 3 or 4 in 38.7 % of patients. One treatment related death was also reported. Non-hematological toxicity was minor and easily controlled. There were no significant statistical differences in the survival benefit and toxicity between the two doses. Conclusion : Docetaxel, as second-line monotherapy, was well tolerated and effective in patients with non-small-cell lung cancer who failed first line platinum -based chemotherapy. (Tuberc Respir DiS 2005: 58: 465-472)

진행성 비소세포폐암의 이차항암화학요법으로서 Docetaxel 단독요법의 성적

강현모,이정은,장필순,이연선,권선중,안진영,정성수,김주옥,김선영 충남대학교 암공동연구소 2006 암공동연구소 업적집 Vol.5 No.

Background : The survival benefit associated with first-line chemotherapy in lung cancer has led to the need for second -line chemotherapy, for which Docetaxel (Taxotere^(?)) has proven efficacy in both settings. This study evaluated the safety and efficacy of docetaxel in patients with non-small cell lung cancer who had failed first-line platinum-based chemotherapy. Methods : Thirty one patients with non-small-cell lung cancer, who had failed first line platinum-based chemotherapy, between March 1999 and August 2003, were enrolled in this study. Patients received intravenous docetaxel, either 75 mg/㎡ or 100 mg/㎡, with routine premedication every three weeks. Results : Fourteen patients (45.2%) had a partial response. The median survival and progression- free survival times were 12.5 months (95% CI 7.3-17.6) and 3.0 months (95% CI 1.6-4.5), respectively. This study showed 2 factors gave different survival benefits; the age (< 60 years: 20.1 months vs. > 60 years: 6.6 months, p=0.0105) and the histological type (adenocarcinoma: 25.6 months vs. others: 7.9 months, p=0.0055). The predominant toxicity was neutropenia, which occurred as WHO grade 3 or 4 in 38.7 % of patients. One treatment related death was also reported. Non-hematological toxicity was minor and easily controlled. There were no significant statistical differences in the survival benefit and toxicity between the two doses. Conclusion : Docetaxel, as second-line monotherapy, was well tolerated and effective in patients with non-small-cell lung cancer who failed first line platinum -based chemotherapy. (Tuberc Respir DiS 2005: 58: 465-472) 연구배경 : 일차항암화학요법 후에 생존의 이득을 얻었음에도 불구하고 비소세포폐암 환자들의 대다수가 결국은 재발하거나 진행성 병변을 보인다. 이에 저자들은 기존의 여러 연구에서 보고 된 구제요법으로서 docetaxel의 항암효과와 비교적 적은 독성의 결과를 바탕으로,platinum을 근거로 한 항암화학요법을 시행 밖았으나 개발되거나 진행된 비소세포폐암 환자들을 대상으로 docetaxel 단독요법의 치료효과와 부작용에 대하여 알아보고자 하였다. 방법 : 조직학적으로 비소세포폐암으로 진단을 받고 platinum을 근거로 한 항암화학요법을 받았으나 재발 또는 진행성 병변을 보인 31명의 환자들을 대상으로 docetaxel 75 mg/m² 또는 100 mg/m²을 3주마다 정주하였다. 임상기록을 통한 후향적인 방법으로 분석하였다. 결과 : 1) 재발 또는 진행성 병변을 보인 31명중 남녀 비는 24:7이고 중앙연령은 60세였다. 2) 반응평가로 완전 관해는 없었고 부분관해는 14명(45.2%), 불변이 10명(32.3%), 진행이 7명(22.6%)으로 전체적인 반응율은 45.2%이었다. 3)중앙생존기간은 12.5개월(95% 신뢰구간: 7.3개월 17.6개월) 이었고, 1년 생존율은 52%였다. 무진행생존기간의 중앙값은 3.0개월(95%신뢰구간: 1.6개월 -4.5개월)이며, 반응군에서의 중앙반응지속피간은 3.7개월(95% 신뢰구간: 3.0개월 - 4.4개월)이었다. 4) 60세 미만인 경우(20.1 months vs 6.6 months. p=0,0105), 조직학적 아형이 선암일 경우(25.6 months vs 7.9 months, 0=0.0055) 통계적으로 유의한 생존기간의 증가가 있었다. 5) 부작용으로 3도 이상의 백혈구 감소증은 12명(38.7%),호중구 감소증에 동반된 발열은 6명(19.3%),감염이 동반된 호중구 감소증은 4명(12.9%)에서 발생했다. 치료와 관련되어 1명이 사망하였다. 6) Docetaxel 용량에 따른 생존기간의 차이나 독성의 차이는 없었다. 결론 : Platinum을 근거로 하는 항암화학요법으로 치료받은 후 재발 또는 진행성 병변을 보이는 비소세포폐암환자들에게 docetaxel을 투여하는 것은 비교적 안전하고 효과적인 항암치료법으로 사료된다.

PCR을 이용한 Rat 기관지 세척액에서의 Pneumocystis carinii DNA의 검출 : 기초실험 A pilot study

김주옥,홍석철,한표성,이종진,김선영,이영하,신대환 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.1

Background: Pneumocystis carinii (PC) is a opportunistic pathogen causing serious pneumonia (Pneumocystis carinii pneumonia : PCP) in immunosuppressed patients including AIDS. Laboratory diagnosis of PCP is dependent on microscopic demonstration of the PC by using cytochemical staining or by immunocytochemical staining with monoclonal antibodies. However, these staining methods are not highly sensitive. The development of the polymerase chain reaction (PCR) has made it possible to detect very small numbers of pathogens in clinical specimens. To establish the usefulness of PCR for detection of PC DNA, We performed PCR as a pilot study. Methods: PCP was induced on Spraque-Dawley rats with prednisolone 5mg IM twice a week. Bronchial lavages, impression smears, and permanent sections were performed from the 3rd week to 7th week of cortisonized rats. PC DNA was extracted with bead beater / 10% CTAB method. Results: Impression smears showed PC cyst after the 4th week (100%, 28/28 rats), and permanent sections showed 27/28 rats. Control rats showed some PC cysts (2/7). PCR result was positive only one case among the 6th week rats (1/7), But positive 6 cases at the 7th week rats, (6/7). Among control rats. 2 cases were positive (2/7). ??This data is a pilot study for the PC DNA detection using a PCR. PCP were successfully cortisonized rats. If adequate bronchial washing technique will be used, PCR can be a sensitive for PC DNA detection.

테녹시캄과 β-시콜로멕스트린 간의 고체분산체 형성에 의한 용출 증가

박옥선,전인구 동덕여자대학교 종합약학연구소 2001 동덕약학연구지 Vol.5 No.-

The purpose of this study is to investigate the interaction of tenoxicam with various cyclodextrins (CDs) in the aqueous solution and in solid state, and finally to formulate a tablet with enhanced dissolution rate. CDs used in solubility studies were α-, β- and γ -CD, 2-hydroxypropyl-β-CD (HPCD), sulfobutyl ether-β-CD (SBCD), dimethyl-β-CD (DMCD) and trimethyl-β-CD (TMCD). The effect of CDs on the solubility of tenoxicam was observed. Solid dispersions were prepared with β-CD using solvent evaporation and freeze-drying process and physical mixtures were prepared by trituration in a mortar. The ratios of drug to carrier were 1:1 and 1:2 molar ratio. These solid dispersions were evaluated by differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FT-IR) and dissolution studies. Solid dispersions were also formulated to tablets and then dissolution rates were compared with that of a commercial product. In aqueous solution, complex formation with α- and β-CD gives rise to Bs type solubility phase diagram, and DMCD, TMCD, HPCD and SBCD showed AL type diagrams. The solubility increase of tenoxicam was in the order of SBCD>γ-CD>β-CD>HPCD>DMCD>α-CD>TMCD. The presence of water soluble polymers such as povidone and hydroxypropyl methylcellulose in β-CD solution did not increase the solubility of tenoxicam. DSC and FT-IR studies confirmed the formation of an solid complex of tenoxicam with β-CD. Dissolution of solid dispersion was about 4-fold higher than that of drug alone and about 2-fold higher than that of physical mixture within 10 min at pH 1.2. As the ratio of carrier to drug increased, dissolution rate became faster. The dissolution rate of tenoxicam from the tablets prepared using freeze-dried solid dispersion at 1:2 molar raio was fast; more than 80% was dissolved within 15 min at pH 1.2. All tenoxicam tablets prepared using tenoxicam-β-CD solid dispersions showed more rapid dissolution rates than commercial tablets. Therefore, the solid dispersion technique is an effective method for increasing the dissolution rate of poorly water soluble tenoxicam. β-CD was thought to be a candidate carrier for preparing solid dispersion with tenoxicam.

前提指示 및 投射

朴善玉 진주여자전문대학 1987 論文集 Vol.9 No.-

Presupposition is those preconditions that the world must meet in order for the sentence to make literal sense. These preconditions can be devided into semantic presupposition and pragmatic presupposition ; this is the sincerity condition in which the utterance of a sentence and the context (speaker, addressee, audience. physical and cultural environment of the utterance) are included and that is the refering condition which decides the truth value of the sentence. On this theorerical basis this study observed the presuppositional factors and translated each factor's presuppositional features centering on the pricatives (factive verbs, aspect verbs and verbs of judging). Verbs are subcategorized into factive, non-factive and neg-factive , factive ( know, surprise, realize··) presupposes the truth of the complement, neg-factive( pretend·) presupposes the falsity of the complement and non-factive( seem, believe ) does not have such presupposition. Among the aspect verbs the ingressive has negative presupposition and the others have positive presupposition. Verbs of judging( accuse, criticize, scold) can be more pragmatically translated relating to the situation and the men concerned (judge, defendant, affected, addressee). Each presupposition of the constituents is generally projected to that of the complex sentence. Some of those presuppositions, however, are cancelled, when the presupposition of a constituent is itself too semantically (identical, entailed, or negated ) related to the content of the other constituent. This study showed these presuppositions of complex sentences on the basis of cumulative hypothesis and filtering theory.

가사노동 관리자유형과 관련 변인에 관한 연구

이선화,채옥희 圓光大學校大學院 1996 論文集 Vol.17 No.-

The purpose of this study is to investigate household work manager style and it's related variables. The subjects of this study were 111 homemakers living in Ik-San. Survey methods were qustionnaire. Data analysis strategies were percentile, frequency, and X2 - test. Following are the results: 1. The characteristics of management in household work have the person orientation. 2. Household work manager style exhibit the related style in his study. The related style is higher the person orientation than the task orientation. 3. Household work manager styles exhibit different in socio-demographic variable such as homemaker's job. Employed wives show the dedicated style but full-time homemakers show the seperated style.

간호학생들이 경험한 간호행위의 종류와 경험시 느끼는 스트레스 정도에 대한 조사연구

李鈺淑,徐仁善 全北大學校 1995 論文集 Vol.39 No.-

This study was performed to examine the kind of nursing activities which nursing student had experienced, and the degree of stress perceived during the period of nursing activities. It was carried out on Sep. 30, 1994. The object of study was 70 senior nursing students in Chon-Ju and Dae-Jeon selected from 2 universities by questionnaire. The collocted data was analyzed by statistical method. The results obtained from this study are summerized as follows : 1. The total experience rate of 10 nursing fields was 89.7%. On which, the students-themselved practiced rate was 66.9% and the observation rate was 22.8%. 2. The students-themselves practiced rates in nelaton catheterization, measuring vital signs, position change, and intramuscular injection were 100%. 3. The highest rank of inexperience rate was colostomy irrigation(67.1%). The inexperience rates in bed bath, artificial respiration were 65.7%, 64.3%. 4. The average of degree of stress student received in 10 nursing fields : Mean score was 2.143, when maximum score was 5. The highest rank of degree of stress was suction(2.771), elimination and irrigation(2.366), and recording(2.291) were other nursing fields of higher rank. The lowest rank of degree of stress was comfort and heat therapy(1.600). 5. The degree of stress in 50 nursing activities, the highest rank of degree of stress was tracheal suction(3.120), foley catheterization(2.929), nasal, oral suction(2.739) were other nursing activities of higher rank. The lowest rank of degree of stress was cold compress(1.174). 6. In regard to the motive for majoring in nursing, the occupational stability had the highest percentage(41.4%), and self-confidence in nursing activities(M=2.89), and knowledge in nursing activities(M=2.94) were in the middle range. 7. When we examind mutual relation between stress degrees in each nursing field and self confidence and knowledge about nursing activities, self confidence about nursing activities appeared to have reverse relations in the field of oxygen supply and cardio-pulmonary resuscitation(r=-.2344,P<.05). Knowledge about nursing activities appeared to have reverse in the field of measuring status value(r=-.2402,P<.05).

서산 간척지의 염도와 벼의 생육에 관한 연구

이희선,김옥봉 西原大學校 基礎科學硏究所 1998 基礎科學硏究論叢 Vol.12 No.-

The effects of salinity on the growth and production of rice were studied at Seosan reclaimed land from July to October, 1995. The plant height, the number of living leaves, dead leaves and total leaves, the number of the grains and the dry weight of the grains per individual, and the dry weight of above the ground in 25cm×25cm quadrat were investigated on 5 plots where were different salinity. The plant height, the number of living leaves and total leaves and the number of grains and the dry weight of grains per individual, and the dry weight of above the ground decreased as the salinity of water increase and the number of dead leaves of rice increased as the salinity of water decrease. The effect of salinity on the reproductive production is severer than the vegetative production. Because of the salinity, the growth and the production of the rice at Seosan reclaimed land are worse than the normal rice field.

20대 성인 남녀 발의 형태분류와 유형별 특성 분석

辛璇遇,咸玉相 服飾文化學會 1999 服飾文化硏究 Vol.7 No.1

For a ideal construction of shoes, the exact analysis for shape and size of foot is necessary. This study was performed to classify and analyze the foot types of young males and females. For this, methods of cluster analysis, correspondence ananlysis and value of proportion were used. The subjects were 414 college students and 36 items, weight(1 item), height(8 items), length(6 items), breadth(6 items), girth(7 items), depth(3 items), slope(5 items) on foot were measured. The fundamental results of the study were as follows ; Difference in foot shape between men's and women's feet was not found below ankle girth. Based on cluster analysis the shapes of foot were classified into five groups, small but relatively slim group, small but relatively barrel group, middle group, large but relatively slim group and large but relatively barrel group. The types of foot had the distinguished dominant characteristics according to sex, weight and height. The results of this study show that there must be the suitable design of shoes for each foot type.

호흡기 감염에서 Sparfloxacin 의 임상적 유용성에 대한 Enoxacin과의 비교 검토

김주옥,김선영,김관형,서지원,박석영,이종진,박성학 대한감염학회 1995 감염 Vol.27 No.4

목적:폐렴, 기관지염, 만성기관지염에서 fluoroquinolone제제로서 항균력이 강하고, 혈중 반감기가 길고, 객담과 조직내 농도가 높은 sparfloxacin의 안전성과 효과를 enoxacin과 비교하기 위해 본 연구를 시행 하였다. 방법:1994년 10월부터 1995년 4월까지 충남대 부속병원과 대전 성모병원에 내원한 폐렴, 급성기관지염, 만성기관지염이 급성으로 악화된 환자 63명을 대조군(32명)(enoxacin 100 mg 1일 3회 경구투여), 실험군(31명)(sparfloxacin 200mg 1일 1회 경구투여)으로 나누어 임상증상, 세균학적 객담 검사, 혈액검사, 실험실내 항균력검사로 그 치료율 및 안전성을 비교하였다. 결과: 1) 임상종합 평가, 세균학적 균소실, 안전성, 유용성에서 두군간에 의미 있는 차이는 없었다. 2) 시험관내 항균력검사상 MIC가 실험군이 대조군보다 현저하게 낮았다.(p<0.05). 3) 경미한 두통, 식욕감퇴, 상복부 불쾌감, 설사등이 대조군 9예, 실험군 7예에서 발생하였고, 검사실 소견상 SGOT 혹은 SGPT 의 일시적 경미한 상승이 대조군 2명, 실험군 3명에서, 혈중 creatinine 상승이 실험군 2명에서 있었으나 경미하였다. 결론:이상의 결과로 sparfloxacin은 폐렴, 급성기관지염, 만성기관지염의 악화에서 하루 한번 투여로 enoxacin 하루 3번 투여와 유사하게 효과적이고 안전하며, 시험관내 항균력이 enoxacin보다 월등히 우수하여 임상에서도 유용하게 사용될수 있을것으로 생각된다. Background: Sparfloxacin, a new oral quinolone, has a broad spectrum, potent antimicrobial activity, prolonged half life, high concentration in sputum. The clinical efficacy and safety of sparfloxacin have been reported by some previous clinical studies performed in Japan. The objectives of this study were to evaluate the clinical and antimicrobial efficacy of this drug in respiratory tract infections compared to those of enoxacin. Methods:We performed an open controlled, randomized study in 63 patients with acute bronchitis, pneumonia, and exacerbation of chronic bronchitis at Chung Nam University hospital and Dae Jeon St. Mary's hospital from October, 1994 to April, 1995. In the control group(n=32), 100 mg enoxacin was administered orally 3 times a day and in the test group(n=31), 200 mg sparfloxacin once a day. Results: The results were as follows; 1) There were no significant differences between the two groups in clinical efficacy, bacteriological finding, and usefulness. 2) Means and SD of MICs were 0.44±0.89 ㎍/ml in the control group, 0.13±0.24 ㎍/ml in the test group. There was a significant difference in MICs between the two groups(p<0.05). 3) Headache, epigastric discomfort, and loss of appetite were observed in 7 cases of the control group and in 9 cases of the test group, and transient elevations of hepatic enzyme in 2 cases of the control group, and in 3 cases of the test group. There was mild elevation of serum creatinine in 2 cases of the test group. Those laboratory abnormalities by therapy might be associated with their underlying diseases. There were no significant adverse effects caused by the drugs Conclusion:In conclusion, sparfloxacin of 200 mg once a day was as effective and well tolerated as enoxacin of 100 mg three times per day in the treatment of respiratory tract infections. Sparfloxacin is more potent antibiotics because MICs of sparfloxacin were very lower than those of enoxacin.