Salivary soluble receptor activator of nuclear factor kappa B ligand/osteoprotegerin ratio in periodontal disease and health

Zahra Alizadeh Tabari,Abbas Azadmehr,Mohammad Amir Alizadeh Tabrizi,Jalaloddin Hamissi,Fatemeh Baharak Ghaedi 대한치주과학회 2013 Journal of Periodontal & Implant Science Vol.43 No.5

Purpose: The receptor activator of nuclear factor kappa B (RANK)/RANK ligand (RANKL)/osteoprotegerin (OPG) system plays a significant role in osteoclastogenesis, activation of osteoclasts, and regulation of bone resorption. This study aimed to evaluate the use of the salivary soluble RANKL (sRANKL)/OPG ratio as a diagnostic marker for periodontitis in nonsmokers. Methods: Twenty-five patients with chronic periodontitis and 25 individuals with a healthy periodontium were enrolled in this study. Samples containing 5 mL of unstimulated saliva were obtained from each subject. Salivary sRANKL and OPG concentrations were determined using a standard enzyme-linked immunosorbent assay. Statistical analysis was performed using SPSS ver. 18.0. Results: The levels of sRANKL and OPG were detectable in all of the samples. Positive relationships were found between the plaque index and clinical attachment level and both the salivary concentration of sRANKL and the salivary sRANKL/OPG ratio (P<0.05). The salivary concentration of sRANKL and the sRANKL/OPG ratio were significantly higher in the periodontitis group than in the healthy group (P=0.004 and P=0.001, respectively). In contrast, the OPG concentration showed no significant differences between the groups (P=0.455). Conclusions: These findings suggest that the salivary sRANKL/OPG ratio may be helpful in the screening and diagnosis of periodontitis. However, longitudinal studies with larger populations are needed to confirm these results. Purpose: The receptor activator of nuclear factor kappa B (RANK)/RANK ligand (RANKL)/osteoprotegerin (OPG) system plays a significant role in osteoclastogenesis, activation of osteoclasts, and regulation of bone resorption. This study aimed to evaluate the use of the salivary soluble RANKL (sRANKL)/OPG ratio as a diagnostic marker for periodontitis in nonsmokers. Methods: Twenty-five patients with chronic periodontitis and 25 individuals with a healthy periodontium were enrolled in this study. Samples containing 5 mL of unstimulated saliva were obtained from each subject. Salivary sRANKL and OPG concentrations were determined using a standard enzyme-linked immunosorbent assay. Statistical analysis was performed using SPSS ver. 18.0. Results: The levels of sRANKL and OPG were detectable in all of the samples. Positive relationships were found between the plaque index and clinical attachment level and both the salivary concentration of sRANKL and the salivary sRANKL/OPG ratio (P<0.05). The salivary concentration of sRANKL and the sRANKL/OPG ratio were significantly higher in the periodontitis group than in the healthy group (P=0.004 and P=0.001, respectively). In contrast, the OPG concentration showed no significant differences between the groups (P=0.455). Conclusions: These findings suggest that the salivary sRANKL/OPG ratio may be helpful in the screening and diagnosis of periodontitis. However, longitudinal studies with larger populations are needed to confirm these results.

Salivary soluble receptor activator of nuclear factor kappa B ligand/osteoprotegerin ratio in periodontal disease and health

Tabari, Zahra Alizadeh,Azadmehr, Abbas,Tabrizi, Mohammad Amir Alizadeh,Hamissi, Jalaloddin,Ghaedi, Fatemeh Baharak Korean Academy of Periodontology 2013 Journal of Periodontal & Implant Science Vol.43 No.5

Purpose: The receptor activator of nuclear factor kappa B (RANK)/RANK ligand (RANKL)/osteoprotegerin (OPG) system plays a significant role in osteoclastogenesis, activation of osteoclasts, and regulation of bone resorption. This study aimed to evaluate the use of the salivary soluble RANKL (sRANKL)/OPG ratio as a diagnostic marker for periodontitis in nonsmokers. Methods: Twenty-five patients with chronic periodontitis and 25 individuals with a healthy periodontium were enrolled in this study. Samples containing 5 mL of unstimulated saliva were obtained from each subject. Salivary sRANKL and OPG concentrations were determined using a standard enzyme-linked immunosorbent assay. Statistical analysis was performed using SPSS ver. 18.0. Results: The levels of sRANKL and OPG were detectable in all of the samples. Positive relationships were found between the plaque index and clinical attachment level and both the salivary concentration of sRANKL and the salivary sRANKL/OPG ratio (P<0.05). The salivary concentration of sRANKL and the sRANKL/OPG ratio were significantly higher in the periodontitis group than in the healthy group (P=0.004 and P=0.001, respectively). In contrast, the OPG concentration showed no significant differences between the groups (P=0.455). Conclusions: These findings suggest that the salivary sRANKL/OPG ratio may be helpful in the screening and diagnosis of periodontitis. However, longitudinal studies with larger populations are needed to confirm these results.

WEAK CONVERGENCE THEOREMS FOR 2-GENERALIZED HYBRID MAPPINGS AND EQUILIBRIUM PROBLEMS

Alizadeh, Sattar,Moradlou, Fridoun Korean Mathematical Society 2016 대한수학회논문집 Vol.31 No.4

In this paper, we propose a new modied Ishikawa iteration for finding a common element of the set of solutions of an equilibrium problem and the set of fixed points of 2-generalized hybrid mappings in a Hilbert space. Our results generalize and improve some existing results in the literature. A numerical example is given to illustrate the usability of our results.

A Ca²⁺ selective membrane electrode based on calcium-imprinted polymeric nanoparticles

Alizadeh, Taher,Shamkhali, Amir Naser,Hanifehpour, Younes,Joo, Sang Woo CNRS 2016 NEW JOURNAL OF CHEMISTRY Vol.40 No.10

<P>In this work, a Ca2+ selective PVC-membrane electrode, utilizing nano-sized Ca2+ imprinted polymers as the ionophore, was introduced. The imprinted polymer was prepared by precipitation polymerization in acetonitrile. Various types of commercially available functional monomers including methacrylic acid, acrylic acid and itaconic acid were tested for the synthesis of Ca2+-imprinted polymers. The networked polymers obtained were used as the ionophore of PVC membrane electrodes. The potentiometric responses of the electrodes, prepared using different imprinted polymers, showed that the type of functional monomers used had a crucial effect on the analytical characteristics of the related membrane electrode. The membrane electrode composed of itaconic acid based imprinted polymers showed better Nernstian slope and particularly better selectivity for Ca2+ determination. The effectiveness of itaconic acid for complex formation with Ca2+, in comparison to two other monomers (methacrylic acid and acrylic acid), was demonstrated by density functional theory-based calculations. The type of crosslinker agent had a definitive role in the performance of the related electrode. Divinyl benzene based imprinted polymers led to an electrode with no significant sensitivity for Ca2+; whereas, the utilization of ethylene glycol dimethacrylate led to a sensor with ideally Nernstian response. Other components of the membrane such as the plasticizer and ionic additive as well as the solution pH were evaluated and appropriate conditions were selected. The electrode showed a response time of 10 s with no memory effect. A dynamic linear range of 1 x 10(-6)-1 x 10(-1) mol L-1, a Nernstian slope of 30.3 (+/-0.4) mV decade(-1) and a detection limit of 7.5 x 10(-7) mol L-1 were obtained for the electrode. The utility of the electrode was checked by its use as an indicator electrode in the determination of Ca2+ ions via complexometric titration by EDTA.</P>

ON FRAMES FOR COUNTABLY GENERATED HILBERT MODULES OVER LOCALLY C^*-ALGEBRAS

Alizadeh, Leila,Hassani, Mahmoud Korean Mathematical Society 2018 대한수학회논문집 Vol.33 No.2

Let $\mathcal{X}$ be a countably generated Hilbert module over a locally $C^*$-algebra $\mathcal{A}$ in multiplier module M($\mathcal{X}$) of $\mathcal{X}$. We propose the necessary and sufficient condition such that a sequence $\{h_n:n{{\in}}\mathbb{N}\}$ in M($\mathcal{X}$) is a standard frame of multipliers in $\mathcal{X}$. We also show that if T in $b(L_{\mathcal{A}}(\mathcal{X}))$, the space of bounded maps in set of all adjointable maps on $\mathcal{X}$, is surjective and $\{h_n:n{{\in}}\mathbb{N}\}$ is a standard frame of multipliers in $\mathcal{X}$, then $\{T{\circ}h_n:n{\in}\mathbb{N}}$ is a standard frame of multipliers in $\mathcal{X}$, too.

Genetic Diversity of Fusarium proliferatum Populations from Maize, Onion, Rice and Sugarcane in Iran Based on Vegetative Compatibility Grouping

Alizadeh, Alireza,Javan-Nikkhah, Mohammad,Fotouhifar, Khalil-Berdi,Motlagh, Elahe Rabiee,Rahjoo, Vahid The Korean Society of Plant Pathology 2010 Plant Pathology Journal Vol.26 No.3

Fusarium proliferatum is the causal agent of stalk and root rot disease of maize, foot rot disease of rice, basal and root rot disease of onion and knife cut disease of sugarcane in Iran. In recent years, incidence and severity of these diseases have been increased in Iran. Fifty seven F. proliferatum single-spore isolates collected from diseased maize, rice, onion and sugarcane plants at different areas were used to study genetic diversity by determination of vegetative compatibility groups (VCGs). Chlorate-resistant nitrate non-utilizing (nit) mutants were recovered from selected isolates of F. proliferatum and used in complementation tests. All isolates in which both nit1 and NitM (or nit3) mutants were recovered, demonstrated self-compatibility. Vegetative compatibility tests by pairing nit mutants identified 30 VCGs among 57 isolates. Twenty-three isolates belonged to singlemember VCGs and the remaining 34 isolates, belonged to other seven multimember VCGs. Segregation of F. proliferatum isolates obtained from various area and host plants into different VCGs in Iran is reported for the first time. In this study, none of isolates obtained from rice complemented with any other isolates from onion and sugarcane and, non complementation occurred between onion and sugarcane isolates. Also, only one complementation occurred between one isolate of maize and one isolate of sugarcane and rice. Thus, a correlation between VCGs grouping and host preferences was founded. It is concluded that natural populations of F. proliferatum in Iran are probably genetically divergent and include isolates representing a potential risk for disease development.

The First Report on Chemoselective Biguanide-Catalyzed Henry Reaction under Neat Conditions

Alizadeh, Abdolhamid,Khodaei, Mohammad M.,Abdi, Gisya,Kordestani, Davood Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.11

An efficient synthetic method for direct Henry reaction catalyzed by a biguanide; namely metformin, as an organosuper-base, between a variety of aromatic and aliphatic aldehydes and nitromethane under neat conditions has been developed. Convenient procedure for removal of the catalyst, chemoselective acquiring of ${\beta}$-nitroalcohols as predominant products, as far as possible short reaction time with excellent conversions are advantages of the developed protocol.

Adsorption of methylene blue from an aqueous dyeing solution by use of santa barbara amorphous-15 nanostructure: Kinetic and isotherm studies

Alizadeh, Reza,Zeidi, Amir Techno-Press 2017 Advances in environmental research Vol.6 No.2

Santa Barbara Amorphous-15(SBA-15) nanoparticles were utilized as the inexpensive and effective adsorbents to remove methylene blue dye from the aqueous solution.SBA-15 was created by Zhao et al method. Infrared spectroscopy, X-ray diffraction and scanning electron microscopy (SEM) were used for the evaluated physical properties of SBA-15. The results of diffraction X-ray indicated that was the crystalline structure for it. Also IR spectroscopy indicated was a silica the whole structure of the groups and SEM image verify the structure of relatively identical particles size of SBA-15. Factors affecting adsorption including the amounts of adsorbent, pH and contact time were investigated by a SBA-15 nanomaterial design. The extent of dye removal enhanced with increasing initial dye concentration and pH from 4 to 10. The higher percentage adsorption were obtained under optimum conditions of variables (sorbent dose of 200 mg/liter, initial MB concentration 10 mg/liter, initial pH of 10 and temperature of $25^{\circ}C$). Maximum adsorption happened after the 2 hour and the kinetic processes of the dyes adsorption were described by applying the pseudo-first-order and the pseudo-second-order and the relatively High correlation with the kinetic Ellovich models. It was found that the pseudo-second-order models kinetic equation described the data of dye adsorption with a good correlation (R2>0.999) which indicated chemisorption mechanism. Freundlich and Langmuir adsorption models were investigated in conditions of variables (adsorbent dose 0.01 gr/liter, MB concentration 10, 20, 30 mg/liter, pH of 4, 7, 10, contact time 90 min and temperature of $27^{\circ}C$). The adsorption data were represented by Langmuir isotherm model. These values are higher than the adsorption capacities of some other adsorbents that have recently been published in the literature.

A new hydrogen cyanide chemiresistor gas sensor based on graphene quantum dots

Alizadeh, Taher,Shokri, Mahrokh,Hanifehpour, Younes,Joo, Sang Woo Taylor Francis 2016 International journal of environmental analytical Vol.96 No.8

<P>Graphene quantum dot (GQDs), synthesised via controlled carbonisation of citric acid, were reduced by hydrazine hydrate and then used as hydrogen cyanide (HCN) gas sensors. Checking of the reduction step by Fourier transform infrared spectroscopy (FT-IR) and X-ray photoelectron spectroscopy (XPS) techniques revealed that most of the oxygen-containing functional groups were removed from the GQDs. It was observed the reduction process is necessary for sensitising of GQDs for HCN gas. The electrical resistance of the reduced GQDs was increased as a result of their exposure to HCN gas. Accepting a p-type semiconducting characteristic for GQD material, he above-mentioned behaviour suggested electron donation from HCN to GQD. The sensor response to HCIsil gas was reversible, suggesting a reversible adsorption/desorption phenomenon of HCN to the GQDs. The response as well as the recovery time of the sensor was different depending on the HCN concentration tested. The developed sensor showed linear HCN response from 1 to 100 ppm. The detection limit of the sensor was estimated to be 0.6 ppm (SIN). Relative standard deviation f HCN determination by the developed sensor was calculated to be 5.7% (n = 4, [HCN]= 50 ppm). The sensor response was did not vary significantly within 6 months</P>

Biguanide-Functionalized Fe₃O₄/SiO₂ Magnetic Nanoparticles: An Efficient Heterogeneous Organosuperbase Catalyst for Various Organic Transformations in Aqueous Media

Alizadeh, Abdolhamid,Khodaei, Mohammad M.,Beygzadeh, Mojtaba,Kordestani, Davood,Feyzi, Mostafa Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.8

A novel biguanide-functionalized $Fe_3O_4/SiO_2$ magnetite nanoparticle with a core-shell structure was developed for utilization as a heterogeneous organosuperbase in chemical transformations. The structural, surface, and magnetic characteristics of the nanosized catalyst were investigated by various techniques such as transmission electron microscopy (TEM), powder X-ray diffraction (XRD), vibrating sample magnetometry (VSM), elemental analyzer (EA), thermogravimetric analysis (TGA), $N_2$ adsorption-desorption (BET and BJH) and FT-IR. The biguanide-functionalized $Fe_3O_4/SiO_2$ nanoparticles showed a superpara-magnetic property with a saturation magnetization value of 46.7 emu/g, indicating great potential for application in magnetically separation technologies. In application point of view, the prepared catalyst was found to act as an efficient recoverable nanocatalyst in nitroaldol and domino Knoevenagel condensation/Michael addition/cyclization reactions in aqueous media under mild condition. Additionally, the catalyst was reused six times without significant degradation in catalytic activity and performance.