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First M87 Event Horizon Telescope Results. V. Physical Origin of the Asymmetric Ring
Akiyama, Kazunori,Alberdi, Antxon,Alef, Walter,Asada, Keiichi,Azulay, Rebecca,Baczko, Anne-Kathrin,Ball, David,Baloković,, Mislav,Barrett, John,Bintley, Dan,Blackburn, Lindy,Boland, Wilfred,Bouma American Astronomical Society 2019 ASTROPHYSICAL JOURNAL LETTERS - Vol.875 No.1
First M87 Event Horizon Telescope Results. VI. The Shadow and Mass of the Central Black Hole
Akiyama, Kazunori,Alberdi, Antxon,Alef, Walter,Asada, Keiichi,Azulay, Rebecca,Baczko, Anne-Kathrin,Ball, David,Baloković,, Mislav,Barrett, John,Bintley, Dan,Blackburn, Lindy,Boland, Wilfred,Bouma American Astronomical Society 2019 ASTROPHYSICAL JOURNAL LETTERS - Vol.875 No.1
First M87 Event Horizon Telescope Results. II. Array and Instrumentation
Akiyama, Kazunori,Alberdi, Antxon,Alef, Walter,Asada, Keiichi,Azulay, Rebecca,Baczko, Anne-Kathrin,Ball, David,Baloković,, Mislav,Barrett, John,Bintley, Dan,Blackburn, Lindy,Boland, Wilfred,Bouma American Astronomical Society 2019 ASTROPHYSICAL JOURNAL LETTERS - Vol.875 No.1
First M87 Event Horizon Telescope Results. IV. Imaging the Central Supermassive Black Hole
Akiyama, Kazunori,Alberdi, Antxon,Alef, Walter,Asada, Keiichi,Azulay, Rebecca,Baczko, Anne-Kathrin,Ball, David,Baloković,, Mislav,Barrett, John,Bintley, Dan,Blackburn, Lindy,Boland, Wilfred,Bouma American Astronomical Society 2019 ASTROPHYSICAL JOURNAL LETTERS - Vol.875 No.1
Effect of blood type on anti-α-Gal immunity and the incidence of infectious diseases
Alejandro Cabezas-Cruz,Lourdes Mateos-Hernández,Pilar Alberdi,Margarita Villar,Gilles Riveau,Emmanuel Hermann,Anne-Marie Schacht,Jamal Khalife,Margarida Correia-Neves,Christian Gortazar,José de la Fue 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
The identification of factors affecting the susceptibility to infectious diseases is essential toward reducing their burden on the human population. The ABO blood type correlates with susceptibility to malaria and other infectious diseases. Due to the structural similarity between blood antigen B and Galα1-3Galβ1-(3)4GlcNAc-R (α-Gal), we hypothesized that self-tolerance to antigen B affects the immune response to α-Gal, which in turn affects the susceptibility to infectious diseases caused by pathogens carrying α-Gal on their surface. Here we found that the incidence of malaria and tuberculosis, caused by pathogens with α-Gal on their surface, positively correlates with the frequency of blood type B in endemic regions. However, the incidence of dengue fever, caused by a pathogen without α-Gal, was not related to the frequency of blood type B in these populations. Furthermore, the incidence of malaria and tuberculosis was negatively correlated with the anti-α-Gal antibody protective response. These results have implications for disease control and prevention.
Arantza Infante,Eva Rubio-Azpeitia,Patricia Sa´nchez,Rau´ l Alberdi,Clara I. Rodriguez,Isabel Andia 한국조직공학과 재생의학회 2017 조직공학과 재생의학 Vol.14 No.5
We aim to examine the influence of platelet rich plasma (PRP) and spatial cues in cartilage/bone matrix forming proteins, and to evaluate the mitotic and chemotactic potential of PRP on human mesenchymal stem cells (hMSCs). Directed cell migration towards PRP gradients was assessed in chemotactic chambers, and recorded by time-lapse microscopy. hMSCs cultured in three-dimensional (3D) scaffolds were visualized by scanning electron microscopy; Hoechst dye was used to confirm cell confluence in 3D-constructs and monolayers before experimental treatment. MSCs were treated with 10% PRP lysate or 10% PRP lysate supplemented with TGF-b-based differentiation medium. The expression of cartilage (COL2A1, Sox9, ACAN, COMP), and bone (COL1A1, VEGF, COL10A1, Runx2) fundamental genes was assessed by real time PCR in monolayers and 3D-constructs. PRP had mitotic (p\0.001), and chemotactic effect on hMSCs, Ralyleigh test p = 1.02E - 10. Two and three-week exposure of MSCs to PRP secretome in 3Dconstructs or monolayers decreased Sox9 expression (p\0.001 and p = 0.050) and COL2A1, (p = 0.011 and p = 0.019). MSCs in monolayers exposed to PRP showed increased ACAN (p = 0.050) and COMP (p\0.001). Adding TGF-b-based differentiation medium to PRP increased COMP, and COL2A1 expression at gene and protein level, but merely in 3D-constructs, p\0.001. TGF-b addition to monolayers reduced Sox9 (p\0.001), aggrecan (p = 0.004), and VEGF (p = 0.004). Cells exposed to PRP showed no changes in hypertrophy associated genes in either monolayers or 3Dconstructs. Our study suggests hMSCs have high-degree of plasticity having the potential to change their matrix-forming phenotype when exposed to PRP and according to spatial configuration.