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Abbas A,Abdus-Salam,Adeniyi Adedayo Olabumuyi,Mutiu Alani Jimoh,Sharif Adeniyi Folorunso,Ajibike Ayomide Orekoya 대한방사선종양학회 2020 Radiation Oncology Journal Vol.38 No.3
Inflammatory musculoskeletal conditions are a common group of diseases among the elderly, worldwide. They are characterized by articular degenerative changes accompanied with often debilitating pain. Treatments often involve life-long analgesic therapy or joint replacement in extreme cases. The aim of this current review is to look at the role of radiation treatment with the hope of further study into the effectiveness of radiation treatment in reducing pain, eliminate or reduce the need for life-long analgesic therapy and thereby avoiding the analgesics’ side effects. Extensive literature search was done on PubMed and other available data base and the findings are presented and discussed. Literature showed that many countries in Europe, especially Germany use radiation routinely for the treatment of many degenerative disorders including osteoarthritis with good results and few side effects. A pilot study is therefore recommended with a view to establish the effectiveness or otherwise of this treatment method in patients.
MPK9 and MPK12 function in SA-induced stomatal closure in <i>Arabidopsis thaliana</i>
Khokon, Md. Atiqur Rahman,Salam, Mohammad Abdus,Jammes, Fabien,Ye, Wenxiu,Hossain, Mohammad Anowar,Okuma, Eiji,Nakamura, Yoshimasa,Mori, Izumi C.,Kwak, June M.,Murata, Yoshiyuki Informa UK (TaylorFrancis) 2017 Bioscience, Biotechnology, and Biochemistry Vol.81 No.7
<P>Salicylic acid (SA) induces stomatal closure sharing several components with abscisic acid (ABA) and methyl jasmonate (MeJA) signaling. We have previously shown that two guard cell-preferential mitogen-activated protein kinases (MAPKs), MPK9 and MPK12, positively regulate ABA signaling and MeJA signaling in Arabidopsis thaliana. In this study, we examined whether these two MAPKs are involved in SA-induced stomatal closure using genetic mutants and a pharmacological, MAPKK inhibitor. Salicylic acid induced stomatal closure in mpk9 and mpk12 single mutants but not in mpk9 mpk12 double mutants. The MAPKK inhibitor PD98059 inhibited SA-induced stomatal closure in wild-type plants. Salicylic acid induced extracellular reactive oxygen species (ROS) production, intracellular ROS accumulation, and cytosolic alkalization in the mpk9, mpk12, and mpk9 mpk12 mutants. Moreover, SA-activated S-type anion channels in guard cells of wild-type plants but not in guard cells of mpk9 mpk12 double mutants. These results imply that MPK9 and MPK12 are positive regulators of SA signaling in Arabidopsis guard cells.</P>
I. Reginald Obidike,Igwebuike U. Maduabuchi,Abdus Salam International Centre for Theoretical Physics),Shoyinka S.V. Olumuyiwa 대한수의학회 2007 Journal of Veterinary Science Vol.8 No.1
Potential negative effects of exposure to Nigerian Qua Iboe Brent crude oil on the reproductive system of male rats was investigated. Forty Sprague-Dawley rats were used for the experiment. Exposure to Nigerian Qua Iboe Brent crude oil was achieved via oral administration of increasing doses (0.1, 0.2, and 0.4 ml/rat) every other day for 4 weeks. Cauda epididymal sperm reserves and relative weights of the testes as well as histological features of the testes of rats that received the crude oil treatment were compared to those of control rats. The results described here showed a significant (p < 0.01) dosedependent reduction in the cauda epididymal sperm reserves of rats that received crude oil treatment relative to the control group. The morphology of testes of the crude oil-exposed rats was characterized by the presence of interstitial exudates, degeneration, and necrosis of spermatogenic and interstitial (Leydig) cells. Findings indicate that exposure of male rats to Nigerian Qua Iboe Brent crude oil may have adversely affected their reproductive systems. This may imply possible reproductive health hazards for animals and humans that may be exposed to this environmental pollutant, especially in areas where oil spillage is a common feature.
Li, Jian Hua,Choe, Han,Wang, Ai Fen,Maiti, Kaushik,Wang, Chengbing,Salam, Abdus,Chun, Sang Young,Lee, Won-Kyo,Kim, Kyungjin,Kwon, Hyuk Bang,Seong, Jae Young American Society for Pharmacology and Experimental 2005 Molecular pharmacology Vol.67 No.4
<P>Mammalian type I and II gonadotropin-releasing hormone (GnRH) receptors (GnRHRs) show differential ligand preference for GnRH-I and GnRH-II, respectively. Using a variety of chimeric receptors based on green monkey GnRHR-2 (gmGnRHR-2), a representative type II GnRHR, and rat GnRHR, a representative type I GnRHR, this study elucidated specific domains responsible for this ligand selectivity. A chimeric gmGnRHR-2 with the extracellular loop 3 (EL3) and EL3-proximal transmembrane helix 7 (TMH7) of rat GnRHR showed a great increase in ligand sensitivity to GnRH-I but not to GnRH-II. Point-mutation studies indicate that four amino acids, Leu/Phe(7.38), Leu/Phe(7.43), Ala/Pro(7.46), and Pro/Cys(7.47) in TMH7 are critical for ligand selectivity as well as receptor conformation. Furthermore, a combinatory mutation (Pro(7.31)-Pro(7.32)-Ser(7.33) motif to Ser-Glu-Pro in EL3 and Leu(7.38), Leu(7.43), Ala(7.46), and Pro(7.47) to those of rat GnRHR) in gmGnRH-2 exhibited an approximately 500-fold increased sensitivity to GnRH-I, indicating that these residues are critical for discriminating GnRH-II from GnRH-I. [Trp(7)]GnRH-I and [Trp(8)]GnRH-I but not [His(5)]GnRH-I exhibit a higher potency in activating wild-type gmGnRHR-2 than native GnRH-I, indicating that amino acids at positions 7 and 8 of GnRHs are more important than position 5 for differential recognition by type I and type II GnRHRs. As a whole, these data suggest a molecular coevolution of ligands and their receptors and facilitate the understanding of the molecular interaction between GnRHs and their cognate receptors.</P>
Side-NSM composite technique for flexural strengthening of RC beams
Akter Hosen,Mohd Zamin Jumaat,A. B. M. Saiful Islam,Abdus Salam,Kim Hung Mo 사단법인 한국계산역학회 2017 Computers and Concrete, An International Journal Vol.20 No.4
Reinforced concrete (RC) infrastructures often require strengthening due to error in design, degradation of materials properties after prolong utilization and increases load carrying capacity persuaded by new use of the structures. For this purpose, a newly proposed Side Near Surface Mounted (SNSM) composite technique was used for flexural strengthening of RC beam specimens. Analytical and non-linear finite element modeling (FEM) using ABAQUS were performed to predict the flexural performance of RC specimens strengthened with S-NSM using steel bars as a strengthening reinforcement. RC beams with various SNSM reinforcement ratios were tested for flexural performance using four-point bending under monotonic loading condition. Results showed significantly increase the yield and ultimate strengths up to 140% and 144% respectively and improved failure modes. The flexural response, such as failure load, mode of failure, yield load, ultimate load, deflection, strain, cracks characteristic and ductility of the beams were compared with those predicted results. The strengthened RC beam specimens showed good agreement of predicted flexural behavior with the experimental outcomes.