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Tie1 controls angiopoietin function in vascular remodeling and inflammation
Korhonen, Emilia A.,Lampinen, Anita,Giri, Hemant,Anisimov, Andrey,Kim, Minah,Allen, Breanna,Fang, Shentong,D Amico, Gabriela,Sipilä,, Tuomas J.,Lohela, Marja American Society for Clinical Investigation 2016 The Journal of clinical investigation Vol.126 No.9
<P>The angiopoietin/Tie (ANG/Tie) receptor system controls developmental and tumor angiogenesis, inflammatory vascular remodeling, and vessel leakage. ANG1 is a Tie2 agonist that promotes vascular stabilization in inflammation and sepsis, whereas ANG2 is a context-dependent Tie2 agonist or antagonist. A limited understanding of ANG signaling mechanisms and the orphan receptor Tie1 has hindered development of ANG/Tie-targeted therapeutics. Here, we determined that both ANG1 and ANG2 binding to Tie2 increases Tie1-Tie2 interactions in a 131 integrin-dependent manner and that Tie1 regulates ANG-induced Tie2 trafficking in endothelial cells. Endothelial Tie1 was essential for the agonist activity of ANG1 and autocrine ANG2. Deletion of endothelial Tiel in mice reduced Tie2 phosphorylation and downstream Akt activation, increased FOXO1 nuclear localization and transcriptional activation, and prevented ANG1- and ANG2-induced capillary-to-venous remodeling. However, in acute endotoxemia, the Tie1 ectodomain that is responsible for interaction with Tie2 was rapidly cleaved, ANG1 agonist activity was decreased, and autocrine ANG2 agonist activity was lost, which led to suppression of Tie2 signaling. Tie1 cleavage also occurred in patients with hantavirus infection. These results support a model in which Tie1 directly interacts with Tie2 to promote ANG-induced vascular responses under noninflammatory conditions, whereas in inflammation, Tie1 cleavage contributes to loss of ANG2 agonist activity and vascular stability.</P>
A. Giri,M. M. Mahapatra,K. Sharma,P. K. Singh 한국강구조학회 2017 International Journal of Steel Structures Vol.17 No.1
Present research describes the effect of weld groove designs on residual stresses of thick SS 304LN pipe welds which are commonly utilized for applications such as boiling water reactor system, oil and steam piping. The faying surfaces of the pipe joints were machined to generate conventional and narrow groove geometries for welding. Circumferential multipass pipe welding was carried out without applying preheat and post weld heat treatment. Blind hole drilling technique was employed for measuring hoop and axial residual stresses in narrow and conventional grooved SS 304LN pipe welds considering plasticity and stress concentration effects of hole drilling process. The result exhibited 20 to 30 percent reduction in residual stresses in narrow grooved pipe welds. A finite element model was developed for estimating the pass by pass peak temperature distributions in the pipe welds. Sequentially coupled thermomechanical elastic-plastic analysis of both conventional and narrow groove pipe welds indicated close agreement between the predicted and experimentally determined hoop and axial residual stresses.
A novel SARMA-ANN hybrid model for global solar radiation forecasting
Srivastava, Rachit,Tiwaria, A.N.,Giri, V.K. Techno-Press 2019 Advances in energy research Vol.6 No.2
Global Solar Radiation (GSR) is the key element for performance estimation of any Solar Power Plant (SPP). Its forecasting may help in estimation of power production from a SPP well in advance, and may also render help in optimal use of this power. Seasonal Auto-Regressive Moving Average (SARMA) and Artificial Neural Network (ANN) models are combined in order to develop a hybrid model (SARMA-ANN) conceiving the characteristics of both linear and non-linear prediction models. This developed model has been used for prediction of GSR at Gorakhpur, situated in the northern region of India. The proposed model is beneficial for the univariate forecasting. Along with this model, we have also used Auto-Regressive Moving Average (ARMA), SARMA, ANN based models for 1 - 6 day-ahead forecasting of GSR on hourly basis. It has been found that the proposed model presents least RMSE (Root Mean Square Error) and produces best forecasting results among all the models considered in the present study. As an application, the comparison between the forecasted one and the energy produced by the grid connected PV plant installed on the parking stands of the University shows the superiority of the proposed model.
Shruti Shastri,A K Giri,Geetilaxmi Mohapatra 한양대학교 경제연구소 2017 JOURNAL OF ECONOMIC RESEARCH Vol.22 No.1
The paper examines the twin deficit hypothesis for a panel of eight South Asian and South East Asian economies having a history of persistent deficits on both fiscal and current accounts for the period 1985-2014. The results based on first and second generation panel cointegration tests indicate existence of a long-run relationship among budget balance, interest rate, exchange rate and current account balance. The estimates of long run coefficients obtained from common correlated effects mean group indicate a positive relationship between the two balances, the impact of the budget balance on the current account being stronger. Dumitrescu-Hurlin panel causality and block exogeniety tests suggest a feedback relationship between the two balances. The conventional hypothesis of causation running from budget balance to interest rates, to exchange rates and then to current account balance is however not borne out by the results.
C. Pandey,A. Giri,M. M. Mahapatra 한국강구조학회 2016 International Journal of Steel Structures Vol.16 No.2
The present study describes how the effect of direction of welding is useful to minimize distortion in submerged arc welded double-sided fillet joints. In present work, angular distortion of 12 mm thick double-sided fillet welds was measured for same direction and reverse direction welding. It has been observed that the maximum magnitude of the angular distortion for reverse direction fillet welding is lower. Thermal history in horizontal and vertical plate of fillet welds was also measured for both same direction and reverse direction welding. After welding, the fillet welds were sectioned, polished and etched to measure the effect of direction of welding on weld bead geometry. To predict the temperature distribution and thermal history, a finite element (FE) elasto-plastic thermo-mechanical model has been developed for submerged arc welded double-sided fillet welds by using moving distributed heat source. The three-dimensional FE thermal model was verified by comparing peak temperature obtained with experimental values. The model results matched fairly well with experimental results with a variation of 6 percent for sample 1 and 7.5 percent for sample 2 for the maximum values of distortion, and a variation of 2-8 percent for peak temperatures in horizontal plate and 9 percent in web plate.
( Shruti Shastri ),( A. K. Giri ),( Geetilaxmi Mohapatra ) 한양대학교 경제연구소 2017 JOURNAL OF ECONOMIC RESEARCH Vol.22 No.2
The paper examines the twin deficit hypothesis for a panel of eight South Asian and South East Asian economies having a history of persistent deficits on both fiscal and current accounts for the peri-od 1985-2014. The results based on first and second generation pan-el cointegration tests indicate existence of a long-run relationship among budget balance, interest rate, exchange rate and current ac-count balance. The estimates of long run coefficients obtained from common correlated effects mean group indicate a positive relation-ship between the two balances, the impact of the budget balance on the current account being stronger. Dumitrescu-Hurlin panel cau-sality and block exogeniety tests suggest a feedback relationship between the two balances. The conventional hypothesis of causation running from budget balance to interest rates, to exchange rates and then to current account balance is however not borne out by the results.
Seasonal PM<sub>10</sub> dynamics in Kathmandu Valley
Aryal, R.K.,Lee, B.K.,Karki, R.,Gurung, A.,Kandasamy, J.,Pathak, B.K.,Sharma, S.,Giri, N. Pergamon Press ; Elsevier [distribution] 2008 Atmospheric environment Vol.42 No.37
Data on ambient PM<SUB>10</SUB> levels from six locations in the Kathmandu Valley recorded by means of continuous sampling using low volume air samplers from October 2002 to March 2007 were used to investigate PM<SUB>10</SUB> concentration dynamics in the valley. Monthly average data of the urban areas, which have much higher concentrations than the rural areas, even exceeded the daily standard level of PM<SUB>10</SUB>, in Nepal, 120μmm<SUP>-3</SUP>. Repetitive peaks and troughs each year indicated annual patterns. Monthly average showed seasonal patterns are different between rural area and urban sites. The highest monthly average concentration was observed in February, the end of winter in urban areas where as in rural found in spring, and the lowest concentration was observed in July (monsoon period). The continuous increase in PM<SUB>10</SUB> concentration from December to February in urban areas showed accumulation of PM<SUB>10</SUB> in the ambient air during the wintertime. Rainfall in June and September, during the monsoon period, caused a PM<SUB>10</SUB> concentration decrease, demonstrating that precipitation is effective in removing PM<SUB>10</SUB> from the valley. Cross correlation analyses among the PM<SUB>10</SUB> levels measured simultaneously at the sampling stations showed a poor relationship in winter; however, there were good relationships in the monsoon and post-monsoon seasons. Both the PM<SUB>10</SUB> concentration and the air-mixing environment in the valley were closely associated with the temperature and wind speed.