http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Eckert, Jana K.,Kim, Young J.,Kim, Jung I.,Gurtler, K.,Oh, D.Y.,Sur, S.,Lundvall, L.,Hamann, L.,van der Ploeg, A.,Pickkers, P.,Giamarellos-Bourboulis, E.,Kubarenko, Andriy V.,Weber, Alexander N.,Kabes Cell Press 2013 Immunity Vol.39 No.4
Lipopolysaccharide (LPS) binding protein (LBP) is an acute-phase protein that initiates an immune response after recognition of bacterial LPS. Here, we report the crystal structure of murine LBP at 2.9 A resolution. Several structural differences were observed between LBP and the related bactericidal/permeability-increasing protein (BPI), and the LBP C-terminal domain contained a negatively charged groove and a hydrophobic ''phenylalanine core.'' A frequent human LBP SNP (allelic frequency 0.08) affected this region, potentially generating a proteinase cleavage site. The mutant protein had a reduced binding capacity for LPS and lipopeptides. SNP carriers displayed a reduced cytokine response after in vivo LPS exposure and lower cytokine concentrations in pneumonia. In a retrospective trial, the LBP SNP was associated with increased mortality rates during sepsis and pneumonia. Thus, the structural integrity of LBP may be crucial for fighting infections efficiently, and future patient stratification might help to develop better therapeutic strategies.
A. Eckert,R. Neugebauer,M. Rossinger,M. Wahl,F. Schulz 한국소성가공학회 2011 기타자료 Vol.2011 No.8
This paper deals with the determination of application limits of an already presented method [1] to predict distortion of joined car body assemblies caused by mechanical joining technologies. The investigated method is particularly developed concerning the demands coming from the application in the automotive body production. Parameter studies in simulation and experiment are presented which show the influence of pre-straining and clamping on the joints properties and dimensional accuracy of the assembly. The gained cognitions allow conclusions about the quality of prediction of dimensional accuracy using the proposed simplified model in different joining situations. Finally, the investigated method is applied to a car body assembly.
Hufenbach, J.,Helth, A.,Lee, M.H.,Wendrock, H.,Giebeler, L.,Choe, C.Y.,Kim, K.H.,Kuhn, U.,Kim, T.S.,Eckert, J. Elsevier Sequoia 2016 Materials science & engineering. properties, micro Vol.674 No.-
<P>This work presents an investigation on the influence of rare earth additions (Ce) on the microstructure and mechanical properties of a cast Fe85Cr4Mo8V2C1 (element contents in wt%) tool steel. The applied relatively high solidification rate during the casting process promotes the formation of non-equilibrium phases such as martensite, retained austenite as well as a fine network-like structure of complex carbides. This combination of phases and their morphology results in excellent mechanical properties already in the as-cast state. Cerium additions induce a change in phase formation and resulting mechanical properties. Besides morphological and quantitative changes of the main constituent phases, novel carbo-oxide and carbide phases are formed. To investigate this microstructural phenomenon, X-ray diffraction (XRD), transmission electron microscopy (TEM) and scanning electron microscopy (SEM) combined with energy dispersive X-ray spectroscopy (EDX) were applied. Altogether, the addition of small amounts of the rare earth element cerium together with a tailored casting process results in enhanced mechanical properties compared to the Fe85Cr4Mo8V2C1 alloy and offers new possibilities to obtain high-strength and simultaneously adequate ductile cast steels for advanced tool design. (C) 2016 Elsevier B.V. All rights reserved.</P>
Al-Shehri, Eman Z.,Al-Zain, Afnan O.,Sabrah, Alaa H.,Al-Angari, Sarah S.,Dehailan, Laila Al,Eckert, George J.,Ozcan, Mutlu,Platt, Jeffrey A.,Bottino, Marco C. The Korean Academy of Conservative Dentistry 2017 Restorative Dentistry & Endodontics Vol.42 No.3
Objectives: To determine the combined effect of fatigue cyclic loading and thermocycling (CLTC) on the shear bond strength (SBS) of a resin cement to zirconia surfaces that were previously air-abraded with aluminum oxide ($Al_2O_3$) particles at different pressures. Materials and Methods: Seventy-two cuboid zirconia specimens were prepared and randomly assigned to 3 groups according to the air-abrasion pressures (1, 2, and 2.8 bar), and each group was further divided into 2 groups depending on aging parameters (n = 12). Panavia F 2.0 was placed on pre-conditioned zirconia surfaces, and SBS testing was performed either after 24 hours or 10,000 fatigue cycles (cyclic loading) and 5,000 thermocycles. Non-contact profilometry was used to measure surface roughness. Failure modes were evaluated under optical and scanning electron microscopy. The data were analyzed using 2-way analysis of variance and ${\chi}^2$ tests (${\alpha}=0.05$). Results: The 2.8 bar group showed significantly higher surface roughness compared to the 1 bar group (p < 0.05). The interaction between pressure and time/cycling was not significant on SBS, and pressure did not have a significant effect either. SBS was significantly higher (p = 0.006) for 24 hours storage compared to CLTC. The 2 bar-CLTC group presented significantly higher percentage of pre-test failure during fatigue compared to the other groups. Mixed-failure mode was more frequent than adhesive failure. Conclusions: CLTC significantly decreased the SBS values regardless of the air-abrasion pressure used.
Han, J.H.,Mattern, N.,Vainio, U.,Shariq, A.,Sohn, S.W.,Kim, D.H.,Eckert, J. Elsevier Science 2014 Acta materialia Vol.66 No.-
The influence of Gd addition on the microstructure of Zr<SUB>56</SUB>Co<SUB>28</SUB>Al<SUB>16</SUB> metallic glasses was investigated for the exchange of Zr by up to 20 at.% Gd. Due to the large positive enthalpy of mixing between Zr and Gd, liquid-liquid phase separation occurs during rapid quenching of the melt. For a low concentration of Gd (x=2 at.%), a homogeneous amorphous structure is obtained for the as-quenched state. Early stages of spinodal decomposition are observed in the as-quenched state of the glasses with x=5 and 10 at.% Gd. Gd-enriched clusters 4-7nm in size are formed, as shown by atom probe tomography (APT). Annealing below the crystallization temperature T<SUB>x</SUB> leads to an increase in the amplitude of compositional fluctuations and the analysis of the spatial atomic distribution by APT provides direct evidence of the spinodal character of the decomposition by uphill diffusion of Gd into the clusters. For higher Gd content (x=15 and 20 at.%), a coarsened microstructure of the phase-separated glass is obtained due to growth and coalescence while quenching the melt. The microstructure formation is essentially determined by the thermodynamic properties of the metastable undercooled liquid.
Eman Z. Al-Shehri,Afnan O. Al-Zain,Alaa H. Sabrah,Sarah S. Al-Angari,Laila Al Dehailan,George J. Eckert,Mutlu Özcan,Jeffrey A. Platt,Marco C. Bottino 대한치과보존학회 2017 Restorative Dentistry & Endodontics Vol.42 No.3
Objectives: To determine the combined effect of fatigue cyclic loading and thermocycling (CLTC) on the shear bond strength (SBS) of a resin cement to zirconia surfaces that were previously air-abraded with aluminum oxide (Al2O3) particles at different pressures. Materials and Methods: Seventy-two cuboid zirconia specimens were prepared and randomly assigned to 3 groups according to the air-abrasion pressures (1, 2, and 2.8 bar), and each group was further divided into 2 groups depending on aging parameters (n = 12). Panavia F 2.0 was placed on pre-conditioned zirconia surfaces, and SBS testing was performed either after 24 hours or 10,000 fatigue cycles (cyclic loading) and 5,000 thermocycles. Non-contact profilometry was used to measure surface roughness. Failure modes were evaluated under optical and scanning electron microscopy. The data were analyzed using 2-way analysis of variance and χ2 tests (α = 0.05). Results: The 2.8 bar group showed significantly higher surface roughness compared to the 1 bar group (p < 0.05). The interaction between pressure and time/cycling was not significant on SBS, and pressure did not have a significant effect either. SBS was significantly higher (p = 0.006) for 24 hours storage compared to CLTC. The 2 bar-CLTC group presented significantly higher percentage of pre-test failure during fatigue compared to the other groups. Mixed-failure mode was more frequent than adhesive failure. Conclusions: CLTC significantly decreased the SBS values regardless of the air-abrasion pressure used.
Glassy Dynamics in Giant Magnetoresistive Melt - spun Co - Cu
B. Idzikowski,U. K. Röβler,A. Handstein,D. Eckert,M. Wolf,K. Nenkov,K.-H. Müller 한국자기학회 1999 Journal of Magnetics Vol.4 No.3
We report results on metastable CuCo ribbons at low Co contents (2 and 10 at%), which were prepared by conventional melt-spinning technique and subsequent annealing. The properties of these materials cannot consistently be described by those of an assembly of superparamagnetic single-domain particles. Magnetic measurements related to magnetic dynamics reveal spin-glass-like properties. Especially, we find very slow nonequilibrium relaxation processes in Co_(10)Cu_(90), which depend on prehistory, when probing the relaxation of the resistivity. The results are clear evidence for frustrated interaction effects due to magnetic couplings between Co clusters or precipitates in these alloys.