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띠 연신 PET 필름의 구조와 성질 (I)-일회 띠 연신-
지병철,윤원식,김상용,Ji, Byeong-Cheol,Yun, Won-Sik,Kim, Sang-Yong 한국섬유공학회 1993 한국섬유공학회지 Vol.30 No.4
The effect of zone-drawing conditions on the structure and physical properties of PET films was examined by measuring crystallinity, birefringence and orientation of crystalline and amorphous phases. The crystallinity of the single step zone-drawn PET film increases mote rapidly with drawing temperature than it does with drawing stress. But birefringence and the orientation of the amorphous regions of the samples increase more rapidly with drawing stress than they do with drawing temperature. At lower zone-drawing temperatures. the amorphous phase contribution to the total birefringence is higher than the crystalline phase contribution. At higher zone-drawing temperatures, on the contrary. the crystalline phase contribution to the total birefringence is higher than the amorphous phase contribution.
띠 연신 PET 필름의 구조와 성질 (II)-반복 띠 연신-
지병철,윤원식,김상용,Ji, Byeong-Cheol,Yun, Won-Sik,Kim, Sang-Yong 한국섬유공학회 1993 한국섬유공학회지 Vol.30 No.5
Zone-annealing, stepwise zone-drawing antral high temperature cone-drawing method were adapted for PET samples in order to obtain high modulus and high strength PET aims. The PET samples, drawn by the stepwise zone-drawing method, had the highest tensile modulus of 19 GPa and storage modulus of 4 GPa at 20$0^{\circ}C$. Using high temperature Bone-drawing method, the PET samples with the highest crystallinity were obtained among the three different drawing methods. The effective contribution of crystalline phase to the total birefringence was achieved by the high temperature zone-drawing/zone-annealing method. The stepwise zone-drawing method was most effective to enhance the amorphous chain molecular orientation along the fiber axis.
Zone 연신된 폴리비닐리덴 플루오라이드의 결정구조와 점탄성적 성질
조재환,지병철,김상용,Jo, Jae-Hwan,Ji, Byeong-Cheol,Kim, Sang-Yong 한국섬유공학회 1985 한국섬유공학회지 Vol.22 No.6
Zone drawing of PVDF of Form II crystal was carried out by changing the zone drawing temperature and stress. Form I crystal of PVDF was obtained by this method and was confirmed by IR spectroscoty and X-ray diffraction. Form I and II crystals were transformed to Form II and III crystals, respectively, after they were annealed at the temperatures above 160$^{\circ}C$, but were not transformed at the temperatures below 160$^{\circ}C$. Tan$\delta$ and complex modulus were decreased by stretching the specimens at very high stresses.
기저 혈중 FSH 농도가 높은 체외수정시술 환자의 과배란유도시 저용량 GnRH Agonist 장기투여법의 임상적 유용성
최영식 ( Choe Yeong Sig ),김선미 ( Kim Seon Mi ),김상돈 ( Kim Sang Don ),이동윤 ( Lee Dong Yun ),지병철 ( Ji Byeong Cheol ),구승엽 ( Gu Seung Yeob ),서창석 ( Seo Chang Seog ),최영민 ( Choe Yeong Min ),김정구 ( Kim Jeong Gu ),문신 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.2
목적 : 기저 혈중 FSH 농도가 높은 체외수정시술 환자의 과배란 유도시 half-dose GnRH agonist 장기투여법과 추가 감소 용량 (further reduced dose) GnRH agonist 장기투여법의 임상적 유용성을 평가하고자 하였다. 연구 방법 : 기저 혈중 FSH 농도가 높은 체외수정시술 환자 84명에서 시행된 102주기를 대상으로 후향적 연구를 실시하였다. A군(n=63)은 투여 시작부터 지속적으로 half-dose로 사용한 GnRH agonist 장기투여법을 시행하였고, B군 (n=39)은 half-dose로 시작하여 뇌하수체 억제 후 통상 용량의 1/3 1/4 용량까지 더 줄여 사용한 GnRH agonist 장기투여법을 시행하였다. 과배란유도시 외인성 FSH 또는 hMG를 step-down method로 투여하였고, 이식 배아의 수는 4개 이하로 제한하였으며, 황체기 보강을 위해 progesterone in oil을 근육주사하거나 8% progesterone gel을 질내투여하였다. 결과 : 대상 환자의 임상적 특성에 있어 양군 간에 유의한 차이가 없었다. HCG 투여일의 혈중 estradiol(E₂) 농도는 B군에서 유의하게 높았으며 (1,318.3±1,120.4 vs. 2,054.9±1,773.5 pg/mL, p=0.015), 자궁내로 이식 가능한 배아의 수도 Brnsdptj dbdmlgkrp shvdkTek (2.9±1.7 vs. 3.7±2.0, p=0.027). 고배란유도시 투여된 성선자극 호르몬의 용량, 채취된 난자의 수, 임상적 임신율 등의 시술 결과는 양군 간에 유의한 차이가 없었다. 결론 : 기저 혈중 FSH 농도가 높은 체외수정시술 환자의 과배란유도시 half-dose GnRH agonist 장기투여법을 사용함에 있어 뇌하수체 억제 후 GnRH agonist 용량을 통상 용량의 1/3 또는 1/4까지 감소시키는 투여 방법은 임상적으로 유용하였으며, 지속적 half-dose GnRH agonist 장기투여법의 대체 투여 방법으로 고려할 수 있을 것으로 사료된다. 향후 본 연구 결과를 검증하기 위하여 대규모의 무작위 전향적 연구가 필요할 것으로 사료된다. Objective : To evaluate the clinical efficacy of half-dose and further reduced dose GnRH agonist long protocols for controlled ovarian hyperstimulation (COH) in in vitro fertilization and embryo transfer (IVF-ET) patients with high basal serum FSH level. Methods : One hundred and two IVF-ET cycles performed in 84 infertile patients with high basal serum FSH level (FSH>10.0 mIU/mL) were included in this retrospective study. Study subjects were assigned in two groups: continuous half-dose GnRH agonist long protocol (Group A, n=63) vs. further reduced dose GnRH agonist long protocol (Group B, n=39) from half-dose at the start of GnRH agonist to 1/3 or 1/4 dose after pituitary suppression. Exogenous FSH or hMG was administered for COH in step-down mode, 4 or less embryos were transferred, and intramuscular progesterone or 8% progesterone gel was used for the luteal support. Results : Serum estradiol (E₂) level on hCG day was significantly higher in Group B (1,318.3±1,120.4 vs. 2,054.9±1,773.5 pg/mL, p=0.015). The number of transferable embryos was also significantly higher in Group B (2.9±1.7 vs. 3.7±2.0, p=0.027). There was no statistically significant difference in the outcomes such as the dose of gonadotropins administered, the number of oocytes retrieved, and the clinical pregnancy rate. Conclusion : GnRH agonist long protocol with the reduced dose from half-dose at the start 1/3 or 1/4 of dose after pituitary suppression may be more beneficial for COH in IVF-ET patients with high basal serum FSH level. Further prospective randomized controlled study in a larger scale will be necessary to confirm this findings.
성효숙 ( Seong Hyo Sug ),이시은 ( Lee Si Eun ),김진주 ( Kim Jin Ju ),윤상호 ( Yun Sang Ho ),이준호 ( Lee Jun Ho ),주웅 ( Ju Ung ),지병철 ( Ji Byeong Cheol ),구승엽 ( Gu Seung Yeob ),서창석 ( Seo Chang Seog ),최영민 ( Choe Yeong M 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.1
목적 : 체외수정시술시 배아이식 후 부화 과정의 실패에 의하여 임신이 이루어지지 않는 것으로 추론되는 불임환자, 즉 과거력상 3회 이상 임신 성립에 실패한 환자, 연령이 37세 이상인 환자 그리고 기초 혈중 FSH 농도가 15 mIU/㎖ 이상인 환자를 대상으로 보조부화술의 임상적 유용성을 규명하고자 하였다. 연구 방법 : 1998년 1월부터 2002년 6월까지 서울대학교병원 산부인과 불임클리닉에서 체외수정시술을 시행 받은 117명 (156주기)의 불임환 Objective : To investigate the clinical efficacy of assisted hatching (AH) with partial zona dissection (PZD) in intrauterine embryo transfer in the patients who failed more than 2 times with standard IVF-ET protocol (Group R), were more than 37 years old