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      • KCI등재후보
      • LY294002 Induces G0/G1 Cell Cycle Arrest and Apoptosis of Cancer Stem-like Cells from Human Osteosarcoma Via Down-regulation of PI3K Activity

        Gong, Chen,Liao, Hui,Wang, Jiang,Lin, Yang,Qi, Jun,Qin, Liang,Tian, Lin-Qiang,Guo, Feng-Jing Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.7

        Osteosarcoma, the most common primary mesenchymal malignant tumor, usually has bad prognosis in man, with cancer stem-like cells (CSCs) considered to play a critical role in tumorigenesis and drug-resistance. It is known that phosphatidylinositol 3-kinase (PI3K) is involved in regulation of tumor cell fates, such as proliferation, cell cycling, survival and apoptosis. Whether and how PI3K and inhibitors might cooperate in human osteosarcoma CSCs is still unknown. We therefore evaluated the effects of LY294002, a PI3K inhibitor, on the cell cycle and apoptosis of osteosarcoma CSCs in vitro. LY294002 prevented phosphorylation of protein kinase B (PKB/Akt) by inhibition of PI3K phosphorylation activity, thereby inducing G0/G1 cell cycle arrest and apoptosis in osteosarcoma CSCs. Further studies also demonstrated that apoptosis induction by LY294002 is accompanied by activation of caspase-9, caspase-3 and PARP, which are involved in the mitochondrial apoptosis pathway. Therefore, our results indicate PI3K inhibitors may represent a potential strategy for managing human osteosarcoma via affecting CSCs.

      • KCI등재

        The Innovative Application of Surface Texture in Fashion and Textile Design

        Lin Gong,신주영 한국의류산업학회 2013 한국의류산업학회지 Vol.15 No.3

        This study focuses on ‘texture’ as one of the most important fashion and textile design elements; in addition,it proposes various applications of it. Surface texture is indispensable in fashion and textile design that also factors heavily into innovative creations. Along with technological advances in the fashion industry, surface texture has derived many new and attractive features that provide more opportunities for designers to show various design concepts. Rather than the surface quality of fabrics, surface texture in fashion design creates its identity through a manipulation of materials- an application that tends to be primarily for visual effects without being restricted to decorative purposes. The status and significance of surface texture in various creative fields is explored and the evolution of surface texture is traced by analyzing a number of fashion design cases with representative surface textures. The latest feature of surface texture in fashion and textile design is identified to establish a new classification of surface texture with five groups and technical suggestions. This study provides a theoretical basis for this field of study and a new framework that can be employed in the development of surface textures that use innovative techniques as well as the future application of newly-developed textures.

      • KCI등재

        The Innovative Application of Surface Texture in Fashion and Textile Design

        ( Gong Lin ),( Jooyoung Shin ) 한국의류산업학회 2013 한국의류산업학회지 Vol.15 No.3

        This study focuses on ‘texture’ as one of the most important fashion and textile design elements; in addition, it proposes various applications of it. Surface texture is indispensable in fashion and textile design that also factors heavily into innovative creations. Along with technological advances in the fashion industry, surface texture has derived many new and attractive features that provide more opportunities for designers to show various design concepts. Rather than the surface quality of fabrics, surface texture in fashion design creates its identity through a manipulation of materials- an application that tends to be primarily for visual effects without being restricted to decorative purposes. The status and significance of surface texture in various creative fields is explored and the evolution of surface texture is traced by analyzing a number of fashion design cases with representative surface textures. The latest feature of surface texture in fashion and textile design is identified to establish a new classification of surface texture with five groups and technical suggestions. This study provides a theoretical basis for this field of study and a new framework that can be employed in the development of surface textures that use innovative techniques as well as the future application of newly-developed textures.

      • KCI등재

        Inequalities in Awareness and Attitude towards HPV and Its Vaccine between Local and Migrant Residents Who Participated in Cervical Cancer Screening in Shenzhen, China

        Wei Lin,Yueyun Wang,Zhihua Liu,Bin Chen,Shixin Yuan,Bo Wu,Lin Gong 대한암학회 2020 Cancer Research and Treatment Vol.52 No.1

        Purpose A cross-sectional survey was conducted to evaluate the differences on awareness and attitude towards human papillomavirus (HPV) and its vaccine between local and migrant residents who participated in cervical cancer screening in Shenzhen, China. Materials and Methods A total of 9,855 females sampled from healthcare institutions in 20 street blocks through the Cervical Cancer Prevention Network were surveyed in this study by a self-administered questionnaire. Multivariate logistic regression was conducted to explore the role of the hukou and resident status in the willingness to receive HPV vaccination. Results Local residents had a relatively higher awareness of HPV (62.0% vs. 35.6% vs. 29.9%, p < 0.001) and its vaccine (35.3% vs. 15.4% vs. 14.8%, p < 0.001), as well as a higher willingness to receive HPV vaccination (68.5% vs. 62.5% vs. 56.2%, p < 0.001) than non-permanent residents and floating population. Except for age, education level, marital status, monthly income, having daughter(s), and heard of HPV and its vaccine, the hukou and resident status significantly associated with the willingness to receive HPV vaccination (local residents vs. floating population: odds ratio, 1.216; 95% confidence interval, 1.057 to 1.398). None significant difference on the associated factors was found between local residents and internal migrants (p for interactions > 0.05). Conclusion Inequalities in awareness and attitude towards HPV and its vaccine existed between local and migrant residents in Shenzhen. The hukou and resident status did impact on the willingness to receive HPV vaccination, therefore, it is critical to implement effective health education campaigns on HPV and its vaccine among internal migrants.

      • KCI등재

        UiO-66-derived porous-carbon adsorbents: synthesis, characterization and tetracycline adsorption performance

        Lin Xiaoying,Zeng Weipeng,Chen Yilan,Su Ting,Zhong Qinhua,Gong Linzhu,Liu Yamin 한국탄소학회 2022 Carbon Letters Vol.32 No.3

        A porous-carbon material UiO-66-C was prepared from metal–organic frameworks UiO-66 by carbonization in inert gas atmosphere. Physicochemical properties of UiO-66-C materials were well characterized by Powder X-ray diffraction (PXRD), Scanning electron microscope (SEM), Fourier-transform infrared spectroscopy (FT-IR), Raman spectrometer, N2 adsorption/desorption isotherms (BET), and the adsorption properties of the products were studied UiO-66-C has a high specific surface area up to 1974.17 m2/g. Besides, the adsorption capacity of tetracycline could reach 678.19 mg/g, the adsorption processes agreed well with the pseudo-second-order kinetic model and Langmuir isotherm model.

      • SCIESCOPUS

        Buckling response of offshore pipelines under combined tension and bending

        Gong, Shun-Feng,Ni, Xing-Yue,Yuan, Lin,Jin, Wei-Liang Techno-Press 2012 Structural Engineering and Mechanics, An Int'l Jou Vol.41 No.6

        Offshore pipelines have to withstand combined actions of tension and bending during deepwater installation, which can possibly lead to elliptical buckle and even catastrophic failure of whole pipeline. A 2D theoretical model initially proposed by Kyriakides and his co-workers which carried out buckling response analysis of elastic-plastic tubes under various load combinations, is further applied to investigate buckling behavior of offshore pipelines under combined tension and bending. In association with practical pipe-laying circumstances, two different types of loadings, i.e., bent over a rigid surface in the presence of tension, and bent freely in the presence of tension, are taken into account in present study. In order to verify the accuracy of the theoretical model, numerical simulations are implemented using a 3D finite element model within the framework of ABAQUS. Excellent agreement between the results validates the effectiveness of this theoretical method. Then, this theoretical model is used to study the effects of some important factors such as load type, loading path, geometric parameters and material properties etc. on buckling behavior of the pipes. Based upon parametric studies, a few significant conclusions are drawn, which offer a theoretical reference for design and installation monitoring of deepwater pipelines.

      • KCI등재

        Enhanced Salt Tolerance of Transgenic Vegetable Soybeans Resulting from Overexpression of a Novel Δ1-Pyrroline-5-carboxylate Synthetase Gene from Solanum torvum Swartz

        Gong-Chen Zhang,Wen-Li Zhu,Jun-Yi Gai,Yue-Lin Zhu,Li-Fei Yang 한국원예학회 2015 Horticulture, Environment, and Biotechnology Vol.56 No.1

        Vegetable soybeans [Glycine max (L.) Merrill] are susceptible to salt stress and, thus, soil salinity can severely affect their growth and productivity. To enhance the salt tolerance of vegetable soybeans, a novel Solanum torvum Swartz Δ1-pyrroline-5-carboxylate synthetase gene (StP5CS, GenBank accession number: JN606861) that encodes a critical regulatory enzyme in proline biosynthesis was transformed into the cultivar NY-1001 using an Agrobacteriummediated transformation method. PCR and Southern blot analyses indicated that two independent T0 fertile transgenic plants were generated. The transgenic plants transmitted the transgenes into their T1 progeny in a 3:1 ratio. The T2 and T3 homozygous transgenic lines (HTLs) were examined for salt tolerance in pot and hydroponic cultures, respectively. The StP5CS overexpression conferred salt tolerance in T2 and T3 HTLs. Under NaCl stress conditions, the leaf scorch scores of T2 and T3 HTLs were significantly lower than those of wild-type (WT) plants. The plant height, leaf area, relative chlorophyll content, and number of fresh pods of T2 and T3 HTLs were significantly higher than those of WT plants. Compared with WT plants, T2 and T3 HTLs had significantly higher levels of proline and significantly lower levels of membrane lipid peroxidation. These results indicate that StP5CS overexpression in HTLs results in enhanced salt tolerance associated with higher levels of proline accumulation under salinity stress and that StP5CS can be utilized to improve salinity tolerance in vegetable crop genetic engineering.

      • KCI등재

        Vector Control of Stator-Permanent Magnet Memory Machine Based on Three Magnetization State Manipulations

        Gong-De Yang,Ming-Yao Lin,Nian Li,Li Hao 대한전기학회 2019 Journal of Electrical Engineering & Technology Vol.14 No.1

        Owing to the estimated permanent magnet (PM) flux linkage fluctuation, the stator-PM memory machine employing the continuous magnetization state (MS) manipulation may suffer from frequent MS manipulations and the accidental inverter damage in its extended speed range. In order to deal with this issue, in this paper, a novel vector control based on three MS manipulations is proposed and implemented on the existing hybrid PM axial field flux-switching memory machine. After a brief analysis of the researched machine configuration, the principle of the three MS manipulations, the remedial sliding mode speed regulator and the current distribution strategy are discussed. The simulated results show that the proposed scheme reduces the speed and electromagnetic torque overshoot and improves the dynamic performance. Meanwhile, compared with the flux-weakening control, the wide speed range can be obtained. Finally, the experiment is carried out to verify the validity of the theory.

      • KCI등재

        Comparative Study of Flux Regulation Methods for Hybrid Permanent Magnet Axial Field Flux-switching Memory Machines

        Gong-De Yang,Xinghe Fu,Mingyao Lin,Nian Li,Hao Liu 전력전자학회 2019 JOURNAL OF POWER ELECTRONICS Vol.19 No.1

        This research comparatively studies three kinds of flux regulation methods, namely, stored capacitor discharge pulse (SCDP),constant current source pulse (CCSP), and quantitative flux regulation pulse (QFRP), which are used for hybrid permanentmagnet (PM) axial field flux-switching memory machines (HPM-AFFSMMs). Through an analysis of the operation principleand the series hybrid PM flux regulation mechanism of the objective machine, the circuit topologies and flux regulation processof these flux regulation methods are addressed in detail. On the basis of a simulation, the flux regulation characteristics of theresearched machine during the magnetization and demagnetization processes are comparatively evaluated. Then, machineperformance, including back EMF, direct and quadrature axis inductances, and magnetization and demagnetizationcharacteristics, is quantitatively investigated. Results show that the QFRP enables the HPM-AFFSMM to achieve a lessharmonic component of back EMF by approximately 7.28% and 7.97% at the magnetization and demagnetization states,respectively, and a more complete magnetization process than the SCDP and CCSP.

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