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폴레이트-폴리(에틸렌 이민)-인지질 복합체가 도입된 리포솜에 의한 항암제의 세포흡수성향상
황태원 ( Tae Won Hwang ),한희동 ( Hee Dong Han ),서동환 ( Dong Hoan Seo ),성하수 ( Ha Soo Seong ),김중현 ( Jung Hyun Kim ),신병철 ( Byeong Chul Shin ) 한국조직공학과 재생의학회 2006 조직공학과 재생의학 Vol.3 No.2
Tumor-targeting liposomes that can enhance the intracellular uptake of the liposomes into tumor cells could lead to an improved therapeutic efficacy for the drugs. A new phospholipid derivative, folate-poly(ethylene imine)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine (FPD), which can be incorporated into lipid bilayers of liposomes, was synthesized and the effect of FPD-incorporated liposomes on intracellular uptake into A549 tumor cells was investigated. While the particle size of FPD-liposomes increased with increase of FPD amount in lipid composition, the loading efficiency of anticancer drug, doxorubicin(DOX), into liposomes was FPD amount in lipid composition. DOX-loaded FPD-liposomes showed higher cytotoxicity against DOX-loaded DSPE-liposomes. Fluorescence microscopy and flow cytometry revealed that FPD-liposomes facilitated the DOX uptake into A549 lung carcinoma cells via folate receptor-mediated endocytosis. It was suggested that FPD-liposomes may be a promising carrier enhancement of intracellular uptake of anticancer drugs into tumor cells.