http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
황윤균,김진웅,최장원,황정환,박우람,박기동,서경도 한국고분자학회 2012 Macromolecular Research Vol.20 No.4
This study provides a practical approach that can afford evaluation of drug compound permeability through the skin in which synthetic polymer membranes are used as a proxy. For this, permeation behaviors of a variety of drug molecules through the synthetic membranes were characterized under the iontophoresis condition as well as passive delivery. As a proof of concept, the permeability of caffeine and TriamiondilTM, both of which are model drug compounds, through the membranes correlated with conventional use of porcine skin. The synthetic polymer membranes showed similar drug permeation patterns to that of the porcine skin, which allowed us to apply them to an alternate to the animal skin. Moreover, the application of iontophoresis to the device system enabled the drug molecules to pass through both the polymer membranes and porcine skin. Our study also verified that drug permeation is substantially influenced by the current direction that likely drives either electrorepulsion or electroosmosis under iontophoretic conditions.
전기방사법을 이용한 유용성 생리활성성분을 포함한 고분자 마이크로입자 제조
황윤균 ( Yoon Kyun Hwang ),정민국 ( Min Kuk Jeong ),조성연 ( Sung Yeon Cho ),박성일 ( Sung Il Park ),조은철 ( Eun Chul Cho ) 대한화장품학회 2017 대한화장품학회지 Vol.43 No.1
Ethyl (4-(2,3-dihydro- 1H-indene-5-carboxyamido) benzoate)는 노화방지 효과가 있으나 난용성 및 결정화 특성을 가지고 있어 제형화 및 2차 가공을 통해 입자내 활성성분을 담지시키는데 어려움이 있으며, 3,5,7-trihydroxy-4’-methoxy-8-prenylflavone는 플라보노이드(flavonoid)류의 일종으로 미백기능을 가지고 있으나 복합제형에 사용할 경우 제형의 착색을 일으키는 물질 중 하나이다. 본 연구에서는 전기방사법을 이용하여 유용성/난용성 생리활성성분인 ethyl (4-(2,3-dihydro-1H-indene-5-carboxyamido) benzoate)와 3,5,7-trihydroxy-4’-methoxy-8-prenylflavone 성분을 각각 poly (methyl methacrylate)와 polycaprolactone 고분자 입자 내에 담지 시키고 이를 화장품 제형에 적용했을 때 나타나는 효과에 대해서 기술하였다. 입자내 활성성분을 담지시킨 고분자 입자를 제조하는 과정에는 고분자의 농도, 노즐의 구조, 그리고 고분자와 생리활성 성분의 상용성이 중요한 역할을 하였다. 아울러 3,5,7-trihydroxy-4’-methoxy-8-prenylflavone가 캡슐화된 polycaprolactone 고분자 입자를 금속산화물이 포함된 화장품 제형과 혼합하였을 경우, 고분자 입자는 캡슐화 되지 않은 flavonoid가 제형에 포함되었을 경우 나타나는 착색현상을 방지하는 데 효과적 일 수 있다는 결과를 확인하였다. An anti-aging compound ethyl (4-(2,3-dihydro-1H-indene-5-carboxyamido) benzoate) rapidly crystallizes in emulsion systems, and a flavonoid 3,5,7-trihydroxy-4’-methoxy-8-prenylflavone bearing a whitening function causes coloration of cosmetic compounds when mixed with metal oxides. In this study, an electrospray method was used to encapsulate water-insoluble bioactive compounds in polymeric microparticles. Poly (methyl methacrylate) and polycaprolactone were used to encapsulate ethyl (4-(2,3-dihydro-1H-indene-5-carboxyamido) benzoate) and 3,5,7-trihydroxy- 4’-methoxy-8-prenylflavone, respectively. It was found that polymer concentration, the structure of electrospray nozzle, and compatibility between polymers and bioactive compounds were important factors in the preparation of the particles. Polycaprolactone particles encapsulating 3,5,7-trihydroxy-4’-methoxy-8-prenylflavone was effective in preventing coloration of a cosmetic compound when mixed with metal oxides.