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CT99 발현 신경 세포주에서 익기안신탕(益氣安神湯)의 신경보호 및 항치매 효과
황연규,이소연,윤현덕,신오철,박창국,박치상,Hwang, Yeon-Kyu,Lee, So-Yeon,Yoon, Hyeon-Deok,Shin, Oh-Chul,Park, Chang-Gook,Park, Chi-Sang 대한한의학방제학회 2005 大韓韓醫學方劑學會誌 Vol.13 No.1
Alzheimer's disease(AD) is a geriatric dementia that is widespread in old age. In the near future AD will be the biggest problem in public health service. It has been widely believed that $A{\beta}$ peptide devided from APP causes apoptotic neurotoxicity in AD brain. However, recent evidence suggests that n99 may be an important factor causing neurotoxicity in AD. Mouse Neuro 2A cells expressed with CT99 exhibited remarkable apoptotic cell damage. We invesgated the protective effects of Ikgiansintang water extract(IGA). Findings from our experiment have shown that IGA inhibits the activities of CT99, which has neurotoxicities and apoptotic activities in cell line. In addition treatment of IGA($50{\mu}g/ml$ for 24 hours) partially prevented CT99-induced cytotoxicity in Neuro 2A cells. As the result of this study, In IGA group, the apoptosis in the nervous system is inhibited, the repair against the degerneration of Neuro 2A cells by n99 expression is promoted. Base on these findings, IGA may be beneficial for the treatment of AD.