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오존(O3)․입상활성탄(GAC) 공정을 이용한 맛․냄새 유발물질과 유기물질의 제거특성 평가
함영완,주영길,오효근,이병욱,김현기,김덕구,홍승관 대한상하수도학회 2012 상하수도학회지 Vol.26 No.2
This study assessed the removal characteristics of taste and odor causing compounds (2-methylisoborneol and geosmin) and organic matters, using a pilot-scale ozone/granular activated carbon (O3/GAC) process treating surface water of Pal-dang reservoir in the Han river over a 3-month period. Experiments were conducted to verify the removal efficiency of O3/GAC process which has two different empty bed contact time (EBCT) (O3/GAC column 1 : 10 min and 2 : 15.1 min) with 10.86 min contact time of ozonation at 1.0 mg/L O3. Spiking test using geosmin and 2-MIB was also conducted systematically to mimic the conditions when the algae appears, specifically at the levels similar to the concentrations experienced (geosmin: 250 ng/L) in the winter of 2011. In single ozonation process, organic materials, disinfection by-products (DBPs) and their precursors were disassembled but not removed completely. Meanwhile, it was verified that organic matters, taste and odor causing compounds, and DBPs were well removed when sequentially passing through the GAC process. The pilot results also showed that GAC column with larger EBCT achieved higher removal efficiency. Specifically, in spiking tests, single O3 process showed approximately 89% removal efficiency of geosmin and 2-MIB. O3/GAC combined process demonstrated excellent removal of geosmin and 2-MIB, which are higher than 95%.
Enhanced cell growth inhibition by thiacremonone in paclitaxel-treated lung cancer cells
반정옥,황철주,박미희,황인국,정헌상,이희범,현병국,김지영,윤해석,함영완,윤도영,한상배,송민종,홍진태 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.7
Activation of nuclear factor kappa-B (NF-jB) is implicated in drug resistant of lung cancer cells. Our previous data showed that thiacremonone inhibited activation of NF-jB. In the present study, we investigated whether thiacremonone enhanced susceptibility oflungcancercellstoa common anti-cancer drug paclitaxel by further inhibition of NF-jB. Thus, we used the threefold lower doses of IC50 values (50 lg/ml thiacremonone and 2.5 nM paclitaxel). We found that combination treatment with thiacremonone and paclitaxel was more susceptible (combination index; 0.40inNCI-H460cellsand0.46inA549cells)incellgrowth inhibition of two types of lung cancer cell lines compared to a single agent treatment. Consistent with the combination effect on cancer cell growth inhibition, the combination treatment further induced apoptotic cell death and arrested the cancer cells in G2/M phase accompanied with a much lowerexpressionofcdc2andcyclinB1,andinhibitedcolony formation. Much more inactivation of NF-jB and greater expression of NF-jB target apoptosis regulated genes such as caspase-8 and PARPs were found by the combination treatment. Molecular model and pull down assay as well as MALDI-TOF analysis demonstrated that thiacremonone directly binds to p50. These data indicated that thiacremonone leads to increased apoptotic cell death in lung cancer cell lines through greater inhibition of NF-jB by the combination treatment with paclitaxel.