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임상연구 : 편도절제술을 받은 환아에서 수술 후 통증 조절을 위해 사용한 Ketorolac과 Propacetamol의 비교
이인화 ( In Hwa Lee ),한종인 ( Jong In Han ),김동연 ( Dong Yeon Kim ),이귀용 ( Guie Yong Lee ) 대한마취과학회 2008 Korean Journal of Anesthesiology Vol.55 No.6
Background: Both ketorolac and propacetamol have been used to control mild to moderate pain after operation. Ketorolac is a non-steroid anti-inflammatory drug (NSAID) with strong analgesic activity, but should be avoided in patients with renal dysfunction or bleeding complications. Propacetamol is a prodrug of paracetamol and can be delivered intravenously. Importantly, it has fewer side effects and therefore generally considered safe. The purpose of this study is to compare the analgesic efficacy of ketorolac and propacetamol for pain control after tonsillectomy in pediatric patients. Methods: The pediatric patients were randomly divided into three groups. All patients were given propofol and fentanyl for induction. During induction, one group received ketorolac 1 mg/kg (group K), another group received propacetamol 30 mg/kg (group P), and the other group received saline (group C). Postoperative pain was assessed by Visual Analogue Scale (VAS) and Faces Pain Scale (FPS) at 15, 30 and 60 min after arrival at the recovery room. Results: VAS and FPS at 30 and 60 min after arrival were significantly lower in group K and P than in group C (P < 0.05). No adverse side effect was observed in all groups after tonsillectomy. Conclusions: Propacetamol can be used as a safe alternative to ketorolac for pain control after tonsillectomy in pediatric patients. (Korean J Anesthesiol 2008; 55: 704~8)
임상연구 : 노인환자의 마취유도 시 Remifentanil 투여방법에 따른 혈역학적 변화
임은빈 ( Eun Bin Yim ),이귀용 ( Guie Yong Lee ),한종인 ( Jong In Han ),정락경 ( Rack Kyung Chung ) 대한마취과학회 2007 Korean Journal of Anesthesiology Vol.53 No.6
Background: The elderly have increased sensitivity to opioids and anesthetics. The hemodynamic effects of propofolremifentanil during induction are not known in the elderly. This study was designed to compare two different remifentanil administration methods during propofol-remifentanil induction and tracheal intubation in the elderly. Methods: Forty patients, ages over 65 years were enrolled. Anesthesia was induced with propofol 1 mg/kg and remifentanil. In Group T (TCI : target controlled infusion), remifentanil 3.5 ng/ml were infused until laryngoscopy and tracheal intubation. In Group R (rapid infusion), infusion were stopped when effect-site concentration reaches 5.0 ng/ml. Mean arterial pressure (MAP) and heart rate (HR) were recorded before induction (baseline), after remifentanil reaches its target effect-site concentration, after administration of propofol, 1 minute before intubation, 1 minute after intubation and 3 minute after intubation. Results: In both groups, MAP decreased significantly after induction and then increases significantly after intubation (P < 0.05). In Group R, MAP decreased earlier and was significantly lower than that of Group T (P < 0.05) before intubation. HR shows no significant changes between groups. Conclusions: In these two methods, there are no severe hemodynamic compromise during induction and tracheal intubation in the elderly. However, lesser degree of hypotension occurs in Group T. So we conclude that TCI method can provide better hemodynamic stability than rapid infusion method. (Korean J Anesthesiol 2007; 53: 714∼9)
성상신경절 차단 후 초음파로 확인한 국소마취제 분포가 증상에 미치는 영향
손미경 ( Mi Kyoung Son ),정락경 ( Rack Kyung Chung ),김윤진 ( Youn Jin Kim ),김동연 ( Dong Yeon Kim ),이희승 ( Hee Seung Lee ),한종인 ( Jong In Han ) 대한마취과학회 2009 Korean Journal of Anesthesiology Vol.57 No.5
Background: The aim of this study is to evaluate the effects of local anesthetic distribution on symptoms using ultrasound image after C6 stellate ganglion block (SGB). Methods: Twenty-six patients underwent SGB via an anterior paratracheal approach at the sixth cervical level using 6 ml of 1% mepivacaine. We divided the patients into two groups by local anesthetic distribution using ultrasound image after SGB. In the group `sub`, injected local anesthetic was beneath the prevertebral fascia. In the group `supra`, some of injected local anesthetic was above the prevertebral fascia. The occurrence of Horner`s syndrome, warm sensation on the face and hand, brachial plexus block, hoarseness, and foreign body sensation in the throat were evaluated. The skin temperature of the bilateral thumbs was measured pre and post SGB. Results: The occurrence of hoarseness and the foreign body sensation in the throat was significantly reduced in the group `sub` than the group `supra` (P<0.05). The skin temperature of the ipsilateral thumb significantly increased in both groups compared to the pre SGB values, and the change of the skin temperature significantly increased in the group `sub` than the group `supra` (P<0.05). Conclusions: Subfascial distribution of local anesthetic under ultrasound image after SGB reduces the typical complications. It is more effective in the sympathetic block than suprafascial distribution. (Korean J Anesthesiol 2009;57:579∼83)
수확시기 및 저장온도에 따른 돼지감자 괴경의 가용성당 조성변화
강수일(Su Il Kang),한종인(Jong In Han),김경연(Kyoung Youn Kim),오선진(Sun Jin Oh),김수일(Su Il Kim) 한국응용생명화학회 1993 Applied Biological Chemistry (Appl Biol Chem) Vol.36 No.4
The composition of soluble neutral carbohydrates in Jerusalem artichoke tubers was measured and compared according to harvest dates and storage temperatures using HPLC. The breakdown of inulin (≥GF8) into sucrose and fructo-oligosaccharides (GF2-GF7) was highest on November just after cold-shock. The composition of sucrose and fructo-oligosaccharides on March was much higher than that on September of previous year. Inulin (≥GFB) proportion decreased from 66.4% to 33.1% but the proportion of fructo-oligosaccharides (GF2-GF7) and sucrose increased from 25% to 61% and from 3.4% to 13.6%. respectively. The storage at a low temperature (4℃) for 34 days increased the composition as well. However, the amount of fructo-oligosaccharides was decreased when the tubers harvested in March were stored at high temperature (25∼40℃). For the maximum yield of fructo-oligosaccharides in jerusalem artichoke, it is concluded that the tubers be harvested in March and/or stored at the low temperature.