PET-CT에서 발견되지 않은 동기성 삼중 원발암

한욱경,김동현,윤여훈,구본석 대한이비인후과학회 2009 대한이비인후과학회지 두경부외과학 Vol.52 No.4

As diagnosis and treatment methods of malignant tumors have improved, the average length of a patient's life and the opportunity of detecting multiple primary malignant tumors have also increased. Patients with squamous cell carcinoma of the head and neck often have multiple cancers, esophageal cancer being the most common associated cancer. FDG PET-CT has become an accepted and widely used imaging modality for detecting the metastasis or multiple primary cancers and for the follow-up in the head and neck cancer. We report an unusual case of synchronous triple primary cancer undetected by the PET-CT with a review of literature.

중비갑개에서 발생한 골성혈관종(Osseous Hemangioma) 2예

김용민,한욱경,최진웅,나기상 대한이비인후과학회 2008 대한이비인후과학회지 두경부외과학 Vol.51 No.9

Osseous hemangiomas are uncommon, constituting less than 1% of all osseous tumors. The most frequent sites are the calvaria and the vertebral column. Involvement of the facial bones is rare, and occurs most commonly in the maxilla, mandible, and nasal bones. In nasal cavity, only one case of inferior turbinate involvement has been reported in the English-language literature. We report two cases of osseous hemangioma of the middle turbinate diagnosed by histopathologic confirmation. Because of their infrequent appearance in the nasal cavity, vague symptoms and unknown typical radiologic findings, these tumors can be missed in many cases or may be misinterpreted as other osseous tumors. (Korean J Otorhinolaryngol-Head Neck Surg 2008;51:842-5)

마우스 기도 알레르기 모델에서 interleukin-18의 투여가 알레르기반응에 미치는 영향

윤여훈,한욱경,박석원,김용민,나기상 대한이비인후과학회 2007 대한이비인후과학회지 두경부외과학 Vol.50 No.11

Background and Objectives:The imbalance betwen a Th1 response and a Th2 response may be one feature of allergic disea-ses pathophysiology. IL-18, originally caled the IFN-γ inducing factor, stimulates both Th1 and Th2 responses depending on cytokine milieu. The aim of this study was to investigate and compare the effect of intranasal and intraperitoneal administration of IL-18 in mice with experimentaly induced airway allergy. Materials and Method:Female BALB/c mice were systemically sensitized with ovalbumin mixed with aluminum hydroxide and were challenged with the intranasal instillation of ovalbumin. IL-18 was instilled to nasal cavities or injected into peritoneum acording to the experimental group. After provocation test, bronchoalveolar lavage fluid (BALF) was colected and IL-4, IL-5, IL-18 and IFN-γ were measured. The degree of eosinophil-ic infiltration were evaluated at the peribronchial region of the lung specimen. :The concentration of IL-4 and IL-5 within BALF and peribronchial infiltration of eosinophils were significantly suppressed in the groups treated with IL-18 than in the control group. The intranasal instillation of IL-18 supresed Th2 cytokines more effectively than the intraperitoneal in-jection. Conclusion:It is sugested that allergic inflamation can be supresed with the intranasal instillation of IL-18. (Ko-rean J Otorhinolaryngol-Head Neck Surg 2007 ;50 :996-1000)

소음 노출 후 내이에서 Endothelin-1, Endothelin 수용체 A와 B의 발현양상 변화

허강민,류아라,한욱경,최진웅,나기상,박용호 대한이비인후과학회 2013 대한이비인후과학회지 두경부외과학 Vol.56 No.5

Background and Objectives There are several evidences of reduced cochlea blood flow after noise exposure in the cochlea. However, the pathophysiology of blood flow change is still obscure, and endothelins, proteins that constrict blood vessels and play a key role in vascular homeostasis using its receptors may have importance in this respect. In this study, we investigated the expression changes of endothelin-1 (ET-1), endothelin receptor A (ETAR) and B (ETBR) according to auditory threshold change after noise exposure. Materials and Method Mice were exposed to different noise to generate transient (group 2) and permanent threshold shift (group 3), respectively. Auditory threshold shifts were evaluated with auditory brainstem response and expression changes of ET-1, ETAR and ETBR after noise exposure were evaluated by immunohistochemistry and real time RT-PCR. Results After noise exposure, the increased ET-1, ETAR and ETBR immunoreactivities were observe in stria vascularis, spiral ligament and spiral ganglion neuron. ET-1 mRNA expressions increased after noise exposure in both group 2 and group 3 compared to those of the control group. At 2 weeks after noise exposure, however, the ET-1 mRNA expressions in group 3 increased compared to that of the control but decreased compared to that of group 2. On the other hand, ETAR mRNA expression increased at 2 weeks after noise exposure in both groups, just after noise exposure in group 2 and at 2 weeks after noise exposure in group 3. Conclusion These results suggest that expression changes of ET-1, ETAR and ETBR might be associated with hearing threshold shift and recovery after noise exposure in the cochlea.

기니픽 나선신경절에서 소음노출 후 Erythropoietin 과 Erythropoietin Receptor 의 발현양상

김동현,박재용,김아영,최진웅,한욱경,박용호 대한이비인후과학회 2008 대한이비인후과학회지 두경부외과학 Vol.51 No.1

Objectives:Erythropoietin (EPO) is produced in the kidney and locally in the CNS and acts through binding to erythropoietin receptor (EPO-R). Apart from playing an essential role in erythropoiesis, recent research has shown that EPO has neurotrophic and neuroprotective functions in the CNS and found EPO and EPO-R in the inner ear. The aim of this study is to investigate distribution and expression of EPO and EPO-R in the inner ear after noise exposure. Materials and Method: Normal guinea pigs were exposed to noise. Ten of them were sacrificed at 1 hour of the noise exposure (group B) and another 10 animals were sacrificed at day 7 (group C). Four were normal controls that were not exposed to noise (Group A). Auditory function was evaluated by ABR for 7 days. Noise-induced morphological changes of cochlea were studied by phalloidin stain. The expression of EPO and EPO-R was examined by immunofluorescence. Results:The hearing threshold shift reached a level of 40 dB SPL at 8 kHz at day 1 after noise exposure and underwent a partial recovery at day 7. Increased expression of EPO and EPO-R were observed at the level of spiral ganglion cells in the noise-exposed animals. Conclusion:It is suggested that noise exposure affects the distribution and expression of EPO and EPO-R in the inner ear. (Korean J Otorhinolaryngol- Head Neck Surg 2008;51:16-21)

기니픽에서 Cisplatin 이독성에 대한 Procaine Hydrochloride의 예방적 효과

김아영,김동현,박재용,한욱경,최진웅,박용호 대한이비인후과학회 2007 대한이비인후과학회지 두경부외과학 Vol.50 No.10

Background and Objectives: The use of cisplatin is limited by dose-dependent nephrotoxicity, ototoxicity. Some papers dem-onstrated that procaine hydrochloride increases the therapeutic index of cisplatin, reducing nephrotoxicity, improving antitumor city. Materials and Method:Procaine hydrochloride was used to prevent the ototoxic efects of cisplatin. To evaluate the eficacy, ABR threshold shifts and histopathologic examinations were performed. Results:After injection of cisplatin, ABR indicated that procaine hydrochloride reduced threshold shift significantly. The cochlear hair cels, especially outer hair cels in basal turn, were severely damaged in cisplatin treated group comparing to cisplatin/procaine hydrochloride treated group. In cisplatin/ pro-caine hydrochloride treated cochlea, the apoptotic cells were decreased compared to cisplatin treated group. Conclusion:Proca-ine hydrochloride might protect cisplatin induced ototoxicity in guinea pigs. (Korean J Otorhinolaryngol-Head Neck Surg 2007 ;50 :854-9)

반복적인 오존노출이 마우스에서 기도재형성에 미치는 영향

김용민,김인중,김효선,김아영,한욱경,나기상 대한이비인후과학회 2008 대한이비인후과학회지 두경부외과학 Vol.51 No.3

To investigate whether repeated long-term exposure of ozone has an effect on airway remodeling and whether ozone exposure has an aggravating effect on airway remodeling during allergen challenge in previously sensitized mice. Materials and Method:Forty female BALB/c mice were divided into four groups as follows:Group I as the control group, Group II the ovalbumin aerosol exposure group, Group III the ozone exposure group, and Group IV the ovalbumin aerosol and ozone exposure group. Twenty-four hours after the last OVA challenge, the concentration of IFN-γ, IL-5, IL-13 and TGF-β and the count of eosinophil and lymphocyte were measured in nasal lavage fluid (NLF) and bronchoalvelolar lavage fluid (BALF). Immunohistochemical staining for MMP-9 and TIMP-1 were performed. Trichrome staining was also conducted to evaluate subepithelial fibrosis. Results:Group II and III exhibited increased IL-5, IL-13, and TGF-β in NLF and BALF, compared to Group I;Group IV showed more increased pattern for these cytokines, compared to Group II and III. Group II, III, and IV also showed increased expression of MMP-9 and TIMP-1, compared to Group I in lung;Group II and IV showed more compared to Group I and III in nasal cavity mucosa. Subepithelial fibrosis was prominent in Group II, III, and IV, compared with group I. In group IV, subepithelial fibrosis was more increased than Group II and III. Conclusion:These results suggest that ozone exposure induces remodeling in upper and lower airway and also enhances allergen-mediated airway remodeling in previously sensitized animals. (Korean J Otorhinolaryngol-Head Neck Surg 2008;51:240-9)