http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 최지호(Jeo Ho Choi) (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
-
건선 표피에서의 p53, pRb, p16, p21 및 PCNA에 대한 면역조직화학적 고찰
장성은(Sung Eun Chang),성경제(Kyung Jeh Sung),문기찬(Kee Chan Moon),고재경(Jai Kyoung Koh),최지호(Jeo Ho Choi) 대한피부과학회 1999 대한피부과학회지 Vol.37 No.9
N/A Background : Psoriasis is a chronic disorder which is characterized by hyperproliferation and abnormal differentiation of keratinocytes with T-cell infiltration. There is increasing evidence that inactivation of tumor-suppressor genes can promote uncontrolled cell proliferation and tumor formation. The products of p53, Rb, p16, p21 genes are examples of the molecules the cell growth cycle. Objective : In this study, immunhistochemical analysis of cell cycle-related molecules (p53, pRb, p16, p21Wafl, and PCNA) was done to elucidate the roles and interactions of those molecules in the pathogenesis of psoriatic keratinocytes. Materials and methods : Formalin-fixed skin samples composed of 20 chronic plaque type psoriatic, 20 nonlesional and 20 normal epidermis, and 5 squamous cell carcinomas were included in this study. Results : Our results suggest that p53 protein accumulation is an early event in cutaneous SCC, but not in psoriasis. In our study, diffuse expression of p16 with almost negative expression of pRb in psoriatic epidermis suggest that inverse relationship is maintained. Although loss of p16 expression is frequently associated with many kinds of cancers, we speculate there is a possibility that is a strong expression of p16 is related to localized cancer as well as in benign hyperproliferative lesions. In psoriasis, p21 may be overexpressed via a p53-independent pathway. The number of PCNA positive cells was higher in the psoriatic epidermis in contrast to scattered staining in the psoriatic nonlesional and normal epidermis Conclusion : The proliferative status of psoriatic leratinocytes dose not implicate Rb gene and may not implicate the p53 gene significantly. It is associated with the strong expression of PCNA and moderately increased expressions of p16 and p21. (Korean J Dermatol 1999;37(9) : 1286∼1295)
-
문기찬,성경제,고재경,최지호,김소형 대한피부과학회 1999 大韓皮膚科學會誌 Vol.37 No.7
We report a case of idiopathic subcutaneous type Sweets syndrome in an otherwise healthy 52-year-old woman. She had suffered from recurrent erythematous tender plaques on the trunk and extremities for 4 years. Histopathological examination revealed heavy infiltration of neutrophils and many cytophagic cells in the subcutaneous fat tissue. We suggest that Sweets syndrome, subcutaneous type, should be included in the differential diagnosis of panniculitis.
-
문기찬,성경제,고재경,장경애,안세진,최지호 대한피부과학회 1999 大韓皮膚科學會誌 Vol.37 No.1
Laugier-Hunziker syndrone is a rare, pigmentary disorder of the lips, oral mucosa, and nails. The absence of intestinal polyposis differentiated it from Peutz-Jeghers syndrome. We describe a 16-year-old boy with multiple, brownish, lenticular macules on the lips, oral mucosa, perianal area and anal mucosa, and on the digits of his fingers and toes, in wham intestinal polyposis was not detectable.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
