Nicotine이 Chloesterol 食餌性 家兎動脈 硬化症에 미치는 影響

崔榮龍 최신의학사 1967 最新醫學 Vol.10 No.7

Nicotine is known to have peripheral vasoconstrictive effect through the stimulation of the adrenal medulla and sympathetic ganglia to produce nor-epinephrine (Haimovici 19'8). it is also known for some time that smoking is an important factor in the etiology and tie progression of thromboangitis obliterans (Buerger's disease) and Raynaud's disease. Some authors believe that smoking causes thromboangiitis while others regard smoking as a promoting factor in the progression of the disease. Regardless its etiological role in the development of thromboangiitis obliterans it is well proved that without cessation of smoking the condition is not easily am-enable. The mechanism by which smoking bring about ill-effect on thromboangiitis obliterans is not clear. Sulzberger (1934) demonstrated vascular hypersensitivity to the components of tobacco extracts other than nicotine, whereas many others believe that ill-effect of the smoking is due to the action of nocotine in the tobacco. Huper (1943) examined the histologic changes following a prolonged administration of ,,nicotine in rats and dogs. He found that nicotine causes degenerative changes in the vascular system similar to those induced by the administration of epinephrine. Therefore, the present investigation is undertaken to study the effects of nicotine upon cholesterol-induced atherosclerosis on the assumption that nicotine might enhance atheroma formation. Materialls and Methods Albino rabbits of around 1.8 kg were divided into 8 groups and treated as follows: Group l ; i0 rabbits, given 1 ml of saline per kg plus 1 gm of cholesterol per day. Group R : 6 rabbits, 1 mg of nicotine per kg. Group E : 10 rabbits, 1 mg of nicotine per kg plus 1 gm of cholesterol. Group IV : 6 rabbits, 3 mg of nicotine per kg. Group V : 10 rabbits, 3 mg of nicotine per kg plus 1 gm of cholesterol. Group W : 6 rabbits, 5 mg of nicotine per kg. Group U : 10 rabbits, 5 ml of saline per kg plus 1 gm of cholesterol. Group 1E : 6 rabbits, 1 mg of nicotine per kg. Animals were fed with 300 gms of bean-curd residue per day. Cholesterol was given mixed with a small amount of bean-curd residue once a day at early in the morning. Nicotine (Eastman Kodak product, 97% pure) was diluted in saline in three different concentration to contain 1 mg/ml, 3 mg/ml, and 5 mg/ml, and was given to respective group in respective dose intraperitoneally once a day. Total experimental period lasted for 60 days. During the experimental period, body weight was measured at every 10 days, and serum cholesterol and phospholipids level once every 30 days. After 60 days of cholesterol and nicotine administration, animals were killed by air embolism. The aortas were removed and Sudan IV staining was applied to estimate the degree of gross atheroma formation. Sections from the ascending, thoracic and abdominal portions of the aortas, coronary arteries, carotid arteries, cerebral arteries, renal arteries, femoral arteries, pul onary arteries, liver, adrenals, spleen, and thyroid glands were taken after the fixation in 4% neutral formalin. Microsections were prepared in 6 u thickness after paraffin embeeding. All Sections were stained with hematoxylin-eosin and special stainings were made as required. N3icroscopical studies included the degree and picture of atheroma formation in the aorta, coronary arteries, carotid arteries, cerebral arteries, renal arteries, femoral arteries and pu sonar y arteries. And the degree of lipidosis in the Iiver was also examined. Results and Summary Serum cholesterol increased rather sharply during the first 30 days, but the increase was insidious in spite of continuous feeding of cholesterol thereafter. The smaller dose of nicotine showed enhancing effect on hypercholesterolemia while the larger dose has rather depressing effect. The level of serum phospholipids increased in parallel to cholesterol level as a whole, but the administration of nicotine showed slightly depressing effect reciprocally to the dose of nicotine given. The degree of gross atheroma formation in the aorta was markedly reduced in the groups treated together with nicotine. The degree of inhibition on atheroma formation was parallel to the dose of nicotine administered. Microscopical studies of the aortas and other arteries showed lesser degree of atheroma formation in the aorta among the groups treated ;with nicotine, However, the degree of atheroma formation in the coronary, renal and femoral arteries were not notably different between experimental groups, whereas the atheroma formation in the pulmonary artery and choroid plexus of the brain was inhibited by Iarger dose of nicotine. The changes of vascular wall due to the administration of nicotine alone consisted of Pecrosis, degeneration of elastic fibers, cystic changes and calcification of the media of the aorta, and endothelial hyperplasia with hyaliniation of the media in smaller arteries. Nicotine also showed slight but definite inhibiting effect on the lipids deposition in the liver. In summary, on the contrary to an original assumption that nicotine might have enhancing effect on cholesterol induced atherosclerosis in rabbits, the results obtained by present experiment showed inhibiting effect of nicotine on cholesterol-induced atheroma formation. The mechanism by which nicotine inhibited atheroma formation is not clear, but it may be due to mobilizing action of tissue fat, despression of ser am phospholipids le ;gel, and perhaps stabilizing effect of nicotine on blood lipids.

上部胃腸管 出血의 臨床的 考察

崔榮龍(Y.Y. Choi),劉旻哲(M.C. Yoo),曺章煥(C.H. Cho),閔震植(J.S. Min),黃圭哲(K.C. Whang) 대한외과학회 1972 Annals of Surgical Treatment and Research Vol.14 No.2

賢脈管脂肪平滑筋肉腫

金智煥,崔榮龍,李有福 中央醫學社 1967 中央醫學 Vol.12 No.2

A case of angiolipomyoma with evidence of malignant transformation from a 50 year old housewife is reported. Clinical signs were intermittent colicky and dull flank pain for several years with palpable mass at the right costo-vertebral angle. Urinary findings were not remarkable. No evidence of tuberous sclerosis or adenoma sebaceum was present. The removed kidney showed multiple discrete and deeply yellow tumor nodules scattered throughout renal parenchyma and peripelvic fat tissue mimiking adenocarcinoma of the kidney. Palpation of the opposite kidney at the operation also showed nodularity. Histologically, the tumor consisted of admixture of proliferated blood vessels, smooth muscle cells and mature adipose tissue. The major part of. the tumor showed typical hamartomatous nature of angiolipomyoma, but at several areas, the tumor was quite cellular and monotonous with features of sarcomatous change. The sarcomatous element appeared to derived from smooth muscle cells.

제 23 차 학술대회 : 57. Salmonellosis 에 대한 외과적 고찰

김윤,최영용,황의호,김춘규 대한외과학회 1971 대한외과학회 학술대회자료집 Vol.- No.-

Intra-sellar Meningioma 1例

朴炳文,崔榮龍,李有福 최신의학사 1967 最新醫學 Vol.10 No.4

A case of intra-sellar meningioma is reported in view of the rarity of its kind and difficulty of accurate diagnosis by the clinicicans. The case was a 34 year old house-wife who has complained of vertigo, headiche, weakness of facial muscles, and disturbance of the vision for 5 years without evidence of pituitary hypofunction. At the surgery, a large tumor was found occupying entire sella turcica and extending into the right middle cerebral fossa giving impression of a pituitary adenoma. However, the histopathologic picture of the tumor was a clear cut meningothelial meningioma penetrating into the pituitary parenchyma. But there was still considerable amount of the normal 'pituitary tissue left accounting for the abscence of hypopituitarism clinically.

제 23 차 학술대회 : 51. 한국인 위암환자의 임상통계학적 결론과 그 생존율 ( 16년간 )

황규철,박기일,최영용,신극선,설정현,지훈상 대한외과학회 1971 대한외과학회 학술대회자료집 Vol.- No.-