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김용태(Y . T . Kim),유권(K . Yoo),정현채(H . C . Jung),이효석(H . S . Lee),윤용범(Y . B . Yoon),송인성(I . S . Song),최규완(K . W . Choi),김정룡(C . Y . Kim),최병인(B . I . Choi),최상운(S . W . Choi) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.2
N/A To investigate the prevalance of cholelithiasis in liver cirrhosis, a retrospective study using biliary ultrasonography was performed in 222 patients with liver eirrhosis and in 177 controls. Gallstones were found more often in cirrhotic patients (13.5%) than in controls (5.6%) (p<0.05). Their prevalence was the same in both sexes. The prevalence of gallstone increased in decompensated liver cirrhosis (p<0.05). The prevalence was higher in HBs-Ag negative liver cirrhosis than HBs-Ag positive liver cirrhosis (p<0.01). The linear trend of increasing prevalence with increasing age in non cirrhotic group was not observed in patients with liver cirrhosis. This study confirms, by means of sonography, the high prevalence of cholelithiasis in liver cirrhosis in Korean adults.
체류성 장 증후군에서의 미소융모막효소 활성 및 점액 조성의 변화
백현욱(H . W . Baik),송영욱(Y . W . Song),최상운(S . W . Choi),정현채(H . C . Chung),이효석(H . S . Lee),윤용범(Y . B . Yun),송인성(I . S . Song),김정룡(C . Y . Kim) 대한내과학회 1988 대한내과학회지 Vol.34 No.2
N/A The effect of intestinal bacterial overgrowth on brush border hydrolases and composition of mucus was studied in rats with surgically introduced jejunal self-filling blind 1oops (SFBL), Enzymes and mucus were analyzed from blind loop segments, segments above and below the blind loops in the rats with SFBL, and three corresponding segments in the nonoperated controls. Sucrase and lactase activities were significantly reduced in homogenates from the self-filling blind loop, but alkaline phosphatase was not affected. Lactase activities were significantly reduced in homogenates from the three segments (proximal, blind loop, distal) of small intestine of rats with SFBL. The carbohydrate content of purified mucin was reduced in rats with SFBL than that of normal controls. N-acetyl neuraminic acid was significantly reduced in purified mucin from the SFBL. The results indicate that bacteria enhance the destruction of intestinal surface glycoproteins including disaccharidases. Since alkaline phosphatase, a glycoprotein, is not affected, the destruction is selective and presumably involves only the most exposed membrane components. And among disaccharidases, lactase activities were depressed in segments without direct contact with bacteria, suggesting that bacterial byproducts may exert effect on lactase synthesis systematically.