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기능성 소화불량증 환자에 대한 보화탕(保和湯)의 임상효과
김동우,최빈혜,허진일,박경,김대준,변준석,Kim, Dong-Woo,Choi, Bin-Hye,Hur, Jin-Il,Park, Kyung,Kim, Dae-Jun,Byun, Joon-Seok 대한한의학방제학회 2006 大韓韓醫學方劑學會誌 Vol.14 No.2
Objective: Functional dyspepsia refers to sustainable or repetitive pain at upper stomach related with food intake. This research was intended to observe the improvement of the symptom by administering Bowhatang to a number of functional dyspepsia patients and to clarify its clinical effects. Method: The research was performed upon the appropriate 36 patients conforming to the criteria after being diagnosed with functional dyspepsia among the 87 patients who visited the department of internal medicine at Gumi Oriental Hospital of Daegu Haany University for digestive diseases and were administered with Bowhatang. Result: 91.8% of the patients had upper stomach globus symptoms. which is of the largest percentage. and 13.5% had hunger pain. which is of the least percentage. After administering Bowhatang. by and large Likert scale was significantly reduced. According to the subjective improvement evaluation by the patients. 32 patients(86%) were improved. and 3 patients(8%) had neither improvement nor relapse. while 2 patients ( 6%) were relapsed. Conclusion: Bowhatang has shown significant improvement about the symptoms for functional dyspepsia patients. It is predicted when more outcomes become available from researches on side effects or toxicity of Bowhatang later on. it will be more often used in the clinic.
보중익기합대칠기탕(補中益氣合大七氣湯) 추출물의 ICR마우스에서 경구 단회투여독성 평가
배영철,최빈혜,김동우,허진일,김대준,변준석,Bae, Young-Chul,Choi, Bin-Hye,Kim, Dong-Woo,Hur, Jin-Il,Kim, Dae-Jun,Byun, Joon-Seok 대한한방내과학회 2005 大韓韓方內科學會誌 Vol.26 No.2
An herbal water extract of Bojungikkeehapdaechilkitang(BDT) was prepared to test it for single-dose and repeated-dose toxicity, genotoxicity and reproductive toxicity, and to obtain a 50% lethal dose$(LD_{50})$, approximated lethal dose(ALD), and approximated target organs for BDT. The extract was tested on female and male ICR mice according to KFDA Guideline 1999-61 at doasge level of 2000, 1000, 500, 250 and 125mg/kg/10mL In this study, clinical signs, mortalities and gross findings of principal organs were observed for 14 days of single dosing, and afterwards in some cases. The ALD and $LD_{50}$ of BDT extract obtained in this study was>2000mg/kg for both male and female ICR mice. Also, any possible digestive toxicity of BDT extract was found to be above 1000mg/kg in both male and female ICR mice. The results of this study strongly suggest that BDT extract has no toxic effect at dosage level below 500mg/kg.
대승기탕(大承氣湯) 투여 후 편폐(便閉 ), 번조(煩燥), 불면(不眠)호전된 중풍 환자 치험 1례
김봉석,임희용,최빈혜,김대준,전연이,조종관,변준석,오중한,Kim, Bong-Suk,Lim, Hee-Yong,Kim, Dong-Woo,Choi, Bin-Hye,Kim, Dae-Joon,Jun, Yeon-I,Cho, Chong-Kwan,Byun, Joon-Seok,Oh, Jung-Han 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.2
In the early stage of stroke, the symptoms of constipation, chest discomfort and insomnia may appear in addition to the general symptoms such as specific limb weakness, dysphasia, headache, dizziness etc.. We administered Daeseungkitang(大承氣湯) to the patient diagnosed with cerebral infarction by MRI. He clearly displayed the usual syndromes of stroke(實證), endogenous wind stirring in the liver(肝風內動) and acceleration of upper chest functions(上焦火盛), ascertainned by Oriental Medical methods. After treatment with Daeseungkitang(大承氣湯), the constipation, chest discomfort and insomnia improved along with improvement of general symptoms of stroke.
경두개 도플러 초음파를 이용한 현훈 환자의 뇌혈관 혈류 측정에 관한 임상적 연구 (중대뇌동맥, 추골동맥 및 기저동맥을 중심으로)
김봉석,오중한,김동우,최빈혜,장우석,서영호,손대용,변준석,임회용,Kim, Bong-Suk,Oh, Jung-Han,Kim, Dong-Woo,Choi, Bin-Hye,Jang, Woo-Seok,Seo, Young-Ho,Son, Dae-Yong,Byun, Joon-Seok,Lim, Hee-Yong 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.3
Objectives : This study was designed to research whether transcranial doppler ultrasound(TCD) can yield a suitable diagnosis or prognosis for dizziness. Methods : To evaluate the blood flow, we measured the mean velocity(Vm), peak systolic velocity(Vs) and pulsatility index(PI) of the middle cerebral artery(MCA), vertebral artery(VA) and basilar artery(BA) in 54 dizziness patients and 44 normal subjects. To investigate the difference between dizziness patients and normal subjects, we selected 54 dizziness patients diagnosed normal by Brain MRI, and 44 normal subjects who did not have any symptoms of hyperlipemia, hypertension, diabetes melitus, heart disease, or smoking, diagnosed normal by Brain MRI. 30-69 year olds were divided into 30-49 year olds, 50-59 year olds and 60-69 year olds. Results : In normal subjects, there was a significantly higher Vm, Vs in the MCA and BA, and Vs in the VA of female subjects, and there was a significant difference in PI in the MCA and BA increasing with age. In comparison with normal subjects, dizziness patients had a significantly lower Vm in the BA. Male dizziness patients had significantly lower PI in the MCA. 30-49 year olds had significantly lower Vm in the BA. Conclusions : The significant difference in blood flow velocities in the BA between dizziness patients and normal subjects suggests that dizziness is related to blocking of blood flow in the BA and that diagnosis and prognosis can be made through TCD. More detailed study of dizziness patients will be needed.
평위산(平胃散)과 보화환(保和丸)으로 호전된 연하장애 환자 2례
김동우,오중한,김봉석,임희용,최빈혜,허진일,변준석,김대준,Kim, Dong woo,Oh, Jung-hwan,Kim, Bong-seok,Lim, Hee-yong,Choi, Bin-hye,Heo, Jin-il,Byeon, Jun-seok,Kim, Dae-jun 대한중풍순환신경학회 2005 대한중풍.순환신경학회지 Vol.6 No.1
Dysphagia is an important complication for the rehabilitative treatment and life quality of stroke patients. This report is about two patients with dysphagia after stroke who were treated with Pyungwesan and Bowhawhan. The severity of the patient's dysphagia was evaluated with stage of dysphagia according to severity. After treatment, dysphagia were remarkably improved(from stage 5 to 2, 5 to 1). This result shows that Pyungwesan and Bowhawhan could be effective against dysphagia after stroke.
생진양혈탕(生津養血湯) 물 추출물의 Streptozotocin 유발 고지혈증에 대한 효과
허현,김대준,변준석,최빈혜,Hur, Hyun,Kim, Dae-Jun,Byun, Joon-Seok,Choi, Bin-Hye 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.2
In the Present study, the therapeutic hypolipemic effect of water extract of Saengjinyanghyl-tang (SJYHT), a herbal extract mixture for treatment of diabetes in oriental medicine was tested in Streptozotocin-induced diabetic hyperlipemic SD rats. For detect the therapeutic effects, the test articles were once a day dosed for 28 days by gastric gavage at a dosage 1000, 500 and 250mg/kg from 25 days after STZ-dosing, and the changes on body weight and gains, serum LDL, HDL, Triglyceride and Total Cholesterol levels were observed In addition, the effects of test articles were compared to that of Simvastatin, a well known hypolipemic agents 10mg/kg-dosing group. Base on these results, although no meaningful effects were detected on the serum HDL levels, it is concluded that Saengjinyanghyul-tang water extracts have relatively good favorable effect treatment of STZ-induced diabetic hyperlipemia because they showed clear evidences inhibit the increase of serum LDL, Triglyceride and Total Cholesterol levels. Therefore, it is expected that Saengjinyanghyul-tang extract has favorable potency to development hypolipemic drugs. In addition, about 1000mg/kg of Saengjinyanghyul-tang extracts have similar effect compared to that of Simvastatin 10mg/kg. The effective dosage of Saengjinyanghyul-tang water extracts in the present study was considered as below 250mg/kg.