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고위험 증식당뇨망막병증에서 범망막광응고 대신에 시행한 유리체절제술
조형훈,최광주,Hyung Hun Cho,M,D,Gwang Ju Choi,M,D 대한안과학회 2007 대한안과학회지 Vol.48 No.1
Purpose: This research is to evaluate the effectiveness of vitrectomy on early vision recovery compared to that of panretinal photocoagulation for the high-risk proliferative diabetic retinopathy (PDR) patients. Methods: A retrospective chart review of 84 high-risk PDR patients (100 eyes) who had undergone panretinal photocoagulation or vitrectomy under the diagnosis the high-risk PDR and followed up at least 12 months. Authors divided them into two different groups ; one with who received PRP, and another with vitrectomy. We investigated both groups` vision change every 3, 6, and 12 months after the treatment. Results: The Vitrectomy group patients showed higher percentage of vision improvement and lower percentage of vision decrease (p≤0.05) than the PRP group patients in 3rd and 6th month. Macular edema decreased in the Vitrectomy group and increased in the PRP group in the 3rd month. Need for additional surgery due to complication showed 26% in the PRP group, and 12% in the Vitrectomy group. Conclusions: We conclude the vitrectomy is more efficient method than PRP for high-risk PDR patients who are in need of early vision recovery.
배양망막색소상피세포에서 젤라틴아제의 발현에 대한 산화스트레스의 영향
박영철,최광주,Young-Chul Park,Gwang-Ju Choi 대한안과학회 2005 대한안과학회지 Vol.46 No.11
Purpose: To evaluate the expression pattern of gelatinases in the human retinal pigment epithelial cell line ARPE-19 in response to oxidative stress. Methods: ARPE-19 cells were exposed to paraquat for 72 hours. The cells were assayed for the mRNA expression of gelatinase A and gelatinase B by reverse transcriptase polymerase chain reaction (RT-PCR). The conditioned media were assayed for the production of gelatinases protein by Western blotting. Also, the inhibitory effect of the antioxidants against oxidative stress to the cells was evaluated. Results: The gelatinase levels in the RPE cells increased under oxidative stress compaired with the control (p〈 0.05). Also, the levels decreased when the cells were incubated with the antioxidant N-acetylcysteine (NAC). Conclusions: Oxidative stress upregulates gelatinase expression in ARPE-19 cells.
홍지원,박영철,최광주,Ji-Won Hong,Young-Chul Park,Gwang-Ju Choi 대한안과학회 2005 대한안과학회지 Vol.46 No.9
Objective: Tuberculosis is a chronic infection caused by Mycobacterium tuberculosis that can appear throughout the entire body; however, intraocular tuberculosis is rare. We report a case of tuberculous neuroretinitis accompanied by periphlebitis. Methods: A 17-year-old female was referred with the diagnosis of retinal vasculitis. In the fundus of her right eye, an edematous disc, serous detachment of the macula, multiple hard exudates, and vascular sheathing around the veins were noted. Also, she had no direct light reflex in her right eye. Although her chest X-ray showed no abnormalities, the Tuberculin test was positive; therefore, the condition was diagnosed with a neuroretinitis accompanied by periphlebitis caused by Mycobacterium tuberculosis. Results: High-dose steroid treatment decreased peripapillary edema but did not improved visual acuity. Treatment with antituberculosis medicine resulted in the recovery of her visual acuity and in fundus changes. Conclusions: Ocular tuberculosis commonly appears as perivasculitis; however, it can cause a visual disturbance by invading the retina and optic nerve simultaneously.
트리암시놀론이 배양망막상피세포에서 생산된 혈관형성관련인자에 미치는 영향
이영창,윤태중,최광주,김대현,Young Chang Lee,Tae Jung Yoon,Gwang Ju Choi,Dae Hyun Kim 대한안과학회 2009 대한안과학회지 Vol.50 No.4
Purpose: To examine the effects of triamcinolone on angiogenesis related factors in cultured human retinal pigment epithelial cells Methods: Human retinal pigment epithelial cells were exposed to triamcinolone, cultured in a hypoxic environment, and expression and production of VEGF and PEDF were subsequently tested by RT-PCR and Western blot. Angiogenesis was measured via a tube formation assay using ECV 304 cells and with a migration assay using human dermal microvascular endothelial cells. Results: Expression and production of VEGF and PEDF were tested by RT-PCR and Western blot, respectively. VEGF abundance was reduced while that of PEDF was unchanged in triamcinolone exposed retinal pigment epithelial cells cultured in hypoxic environment compared with cells with no treatment in hypoxic environment (p<0.05). Tube formation and cell migration were reduced by triamcinolone (p<0.05). Conclusions: These results suggest that triamcinolone affects the secretion of angiogenesis-related factors and suppresses neovascularization. J Korean Ophthalmol Soc 2009;50(4):594-602