의식하 진정법에 관한 보호자의 인식도 및 만족도 조사

최한주,박재홍,김광철,최성철 大韓小兒齒科學會 2008 大韓小兒齒科學會誌 Vol.35 No.4

본 연구는,보호자가 바라보는 진정법의 모습과 이를 통해 보호자들이 얻고자 하는 것과 원하는 것이 무엇인지를 알고 보호자들의 높은 만족도와 능동적인 협조를 이끌어 내기 위한 목적으로 시도되었다. 2006년 7월부터 9월까지 경희대학교 병원 소아치과에 내원한 신환 보호자 168명과 의식하진정법을 경험한 환자의 보호자 50명을 대상으로 설문조사를 실시하였다. 설문지는 신환 보호자용과 진정법 경험 보호자용으로 제작하여 설문을 실시하였다. 조사결과 다음을 알 수 있었다. 1. 일반적인 의식하진정법에 대한 정보의 제공이 주로 주변 사람들에 의해 제한적이고 수동적으로 이루어 졌으며,비전문 적인 성향임을 알 수 있었고,또한 소아치과 진료영역에서의 의식하진정법에 대한 정보의 제공이 부족함을 알 수 있었다. 2. 신환 보호자와 진정법을 경험한 환자 보호자 모두에서 환아의 공포감 감소에 가장 큰 관심을 가지고 있었다. 3. 행동 개선보다는 환아의 심리적 개선에 있어 보호자가 느끼는 만족감이 크며,따라서 진정법 시 행동 개선의 목적 보다는 환아의 공포감및 불안감감소에 초점을 두어야겠다. 4. 신환 보호자의 경우 진정법의 안정성에 대한 인식이 정립되어 있지 않았고,진정법을 경험한 보호자의 경우 모르겠다는 것과 불안하다는 대답이 대부분을 차지하여 경험을 하였음에도 올바른 안전성에 대한 인식을 하지 못하고 있었다. The aim of this study was to recognize guardians' desire and awareness on sedation. and to guide guardians' satisfaction and cooperation. Followings are the conclusion : 1. Information supply about conscious sedation were restrictive and insufficient. 2. Both first-visit guardians and guardians of sedated patients were interested in decrease of dental fear. 3. Doth first-visit guardians and guardians of sedated patients were satisfied with psychological improvement better than behavior improvement. Therefore. decrease of patients' fear and anxiety was essential. 4. Both first-visit guardians and guardians of sedated patients didn' t recognize accurate safety of conscious sedation.

직장에 발생한 원발성 악성 흑색종 1예

이석주,김광일,김동호,김홍성,우상민,최덕례,정현용 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.1

An extremely rare case of primary melanoma involving only rectum is reported. This 59 year-old male patient was admitted to the hospital because of hematochezia, difficulty of defection. Endoscopic examination and radical excision showed polypoid lesion with ulceration which measured 6x6x3cm in 2cm from the anal verge. Histopathologic, H&E stain and electron microscopic examination(EM) were performed from endoscopic biopsies and excisional mass. We are reporting a case primary rectal melanoma with brief review of literature.

Triamcinone acetonide의 유리체강내 주사후 발생한 안내염 3례

김영덕,최광주 朝鮮大學校 附設 醫學硏究所 2003 The Medical Journal of Chosun University Vol.28 No.2

Purpose : We report 3 cases of endophthalmitis that is the most serous complication after intravitreal infection of triamcinolone acetonide. Methods : Of patients that intravitreal injection of triamcinolone acetonide was performed, two eyes of two persons with macular edema due to diabetic retinopathy and one eye of one person with cystoid macula edema after phacoemulsification were complicated by endophthalmitis. We performed gram stain, bacterial culture, intravitreal injection of antibiotics, and pars plana vitrectomy. Results : Serratia marcescens were found in two cases, the other wasn'ts. Final visual acuity was no light perception in 2 casea and 0.3 in 1 case. 목적 : triamcinolone acetonide의 유리체강내 주사 후 발생된 합병증중 가장 치명적인 안내염 3례를 경험하였기에 이를 보고하고자 한다. 대상 및 방법 : 당뇨망막병증으로 인한 황반부종 2명, 2안과 백내장수술후 발생한 낭포성 황반부종 1명, 1안에서 치료를 위해 유리체강내 triamcinolone acetonide 주사 후 발생한 안내염 환자에서 균배양검사, 유리체강내 항생제 주사 및 유리체 절제술을 시행하였다. 결과 : 안내염환자의 균배양검사에서 2례에서는 serratia marcescens가 원인균으로 판명되었고 1례에서는 균이 배양되지 않았다. 최종시력은 2례에서 무광각, 1례에서는 0.3으로 교정되었다.

0.5% Timolol과 2% Dorzolamide의 병용투여군과 cosopt®단독 투여군에서의 안압 하강 효과비교

서정성,최광주,나경수,조남수 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.1

ackground and Objective: This study was designed to compare the IOP decreasing effect between the IOP decreasing effect of patients who were treated with 0.5% Timolol and 2% of Dorzolamide and that of patients who were treated with Cosopt® only being the patients who couldn't be controlled by Timolol adequately. Materials and Method: Twenty eight open angle glaucoma patients, 40 eyes, who weren't able to reach desirable IOP when treated with 0.5% Timolol, were tested. The patients were divided into two groups. In group A 13 patients, 20 eyes, were treated with Timolol and 2% Dorzolamide. In group B 15 patients, 20 eyes, were treated with Cosopt® only. The IOP and side effects were recorded after The 1st week, the 1st month and the 3rd month. Results: After 3 months, the IOP in group A was decreased by 20.5% (4.0mmHg) from 19.5mmHg to 15.5mmHg and the IOP in group B was decreased by 23.7% (4.7mmHg) from 19.8mmHg to 15.1mmHg. There was no statistical significance between the two groups. Conclusion Cosopt® has a similar IOP decreasing effect with that of 0.5% Timolol and 2% Dorzolamide combined. It may increase adaptation of patients by decreasing the number of dispensions.

오렌지로부터 아플라톡신B₁의 정량분석에 관한 연구

장향동,백광균,구경림,옥선미,최진석,고은주,류성렬 한국공업화학회 2004 응용화학 Vol.8 No.2

Aflatoxin B₁ was known to have the strongest poisonous character among Aflatoxin compounds. To search the production of Aflatoxin B1 according to the change of temperature, relative humidity and incubation days, orange incubated with Aspergillus parasiticus KCCM 35078 was incubated at 20℃, 25℃, 30℃ at relative humidity 60%, 70%, 80% and for incubation time 3, 4, 5, 6, 7 days.. Production of Aflatoxin B₁ shows that the highest production appeared at 25℃ and its relative humidity 70%. The result that was quantitatively analyzed by using HPLC was 77.41ppm, and by using Fluoroscence detector was 87.87ppm. - Production of Aflatoxin B₁ shows that the lowest production appreared at 20℃ and its relative humidity 80%(HPLC), 60%(Fluoroscence detector). The result that was quantitatively analyzed by using HPLC was 4.47ppm, and by using Fluoroscence detector was 4.17ppm. The structure of Aflatoxin B₁ was identify with authentic sample by using instrumental analysis methods of GC/MS, ¹H-NMR, FT-IR respectively.

유리체강 내 트리암시놀론 주입으로 치유된 안유육종증 1예

박영철,정민규,최광주 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.3

Sarcoidosis is a granulomatous inflammation that is not made clear in its disease origin, If sarcoidosis involves the eye, systemic oral steroid is treated in general. The authors intend to report a case of completed cured ocular sarcoidosis using high dose steroid and intravitreal thamcinolone acetonide injection.

Development of Machine Learning-Based Clinical Decision Support System for Hepatocellular Carcinoma

( Gwang Hyeon Choi ),( Jihye Yun ),( Jonggi Choi ),( Danbi Lee ),( Ju Hyun Shim ),( Young-suk Lim ),( Han Chu Lee ),( Young-hwa Chung ),( Yung Sang Lee ),( Beomhee Park ),( Namkug Kim ),( Kang Mo Kim 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

Aims: There is a significant discrepancy between the actual choice for initial treatment option for hepatocellular carcinoma (HCC) and recommendations from the currently used BCLC staging system. The aim of this study is to develop a machine learning-based clinical decision support system (CDSS) for recommending initial treatment option in HCC and predicting overall survival (OS). Methods: From hospital records of 1021 consecutive patients with HCC treated at a single center in Korea between January 2010 and October 2010, we collected information on 61 pretreatment variables, initial treatment, and survival status. Twenty pretreatment key variables were finally selected. We developed the CDSS from the derivation set (N=813) using random forest method and validated it in the validation set (N=208). Results: Among the 1021 patients (mean age: 56.9 years), 81.8% were male and hepatitis B virus was positive in 77.0%. Patients with BCLC stages 0, A, B, C, and D were 13.4%, 26.0%, 18.0%, 36.6%, and 6.3%, respectively. The 6 multistep classifier models were developed for treatment decision in a hierarchical manner, and it showed good performance with 76.6-88.4% of accuracy. We also developed 7 survival prediction models for each treatment option, which showed good prediction ability for OS with C-index values ranging from 0.684-0.959. Conclusions: Our newly developed HCC-CDSS model showed good performance in terms of treatment recommendation and overall survival prediction. Our HCC-CDSS model may be used as a guidance in deciding the initial treatment option for HCC.

Optimization of Ultrasound-Assisted Extraction of Antioxidant from Peony Root

Gwang Deok Park,Jong Jin Park,Ibukunoluwa Fola Olawuyi,Yeon Ju Seo,Min Ju Park,Da Hee Choi,Yeon Jeong Choi,Jun Hyun Yun,Won Young Lee 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10

This study applied response surface methodology (RSM) to optimize ultrasonic-assisted extraction conditions of antioxidants from peony roots. The independent variables were extraction temperature (30-70°C), ethanol concentration (20-100%), and extraction time (15-55 min). The dependent variables were bioactive compounds (total polyphenol content, paeoniflorin, and myricetin) and antioxidant activity (ABTS). ABTS and myricetin increases with increasing extraction temperature. On the other hand, at lower ethanol concentrations, paeoniflorin and myricetin contents increased. The superimposing 4D graphs showed that extraction temperature (60-65°C), ethanol concentration (40-50%), and extraction time (40-50 min) were optimal extraction conditions for peony root. The validation experiment results confirmed that the total polyphenol content showed a difference of 2%, ABTS and paeoniflorin 4%, and myricetin 8%. This discovered condition can be said to be the optimal extraction condition for peony roots through the results of validation experiments and statistical analysis.

Control of Dissolution Rate of Sodium-Alginate/Polyacrylamide Hydrogel for Selectively Dissolvable Water-Blocking Device

Gwang-Mook Choi(최광묵),Jin-Ju Choi(최진주),Woo-Cheol Kim(김우철),Hwanmin Hwang(황환민),Myungwoong Kim(김명웅),Min-Jun Kim(김민준) 한국고분자학회 2021 폴리머 Vol.45 No.6

본 연구에서는 나트륨-알지네이트/폴리아크릴아마이드(SA/PAM) 하이드로겔의 온도 및 가교제로 작용하는 N,N′-메틸렌비스아크릴아마이드(MBAAm) 농도에 따른 수용 형태 및 시간 변화를 분석하였다. 실험 결과, 수온이 증가하거나 가교제 농도가 감소할수록 SA/PAM 하이드로겔의 팽윤 및 수용 속도가 증가함을 확인하였다. 수온 상승 시 이온결합이 불안정하고 아마이드 결합이 깨지면서 하이드로겔의 수용 속도를 증가시키는 반면, MBAAm의 밀도 감소 시에는 주요 결합력인 이온결합력이 약화되어 고온수에 취약함을 확인하였다. 본 연구를 통해 SA/PAM 하이드로겔의 수용속도의 제어가 가능함을 증명하였고 선택적 수용이 가능한 차수재로서의 가능성을 제시하였다. The objective of this study was to examine changes in the dissolution rate of sodium-alginate/polyacrylamide (SA/PAM) hydrogel according to water temperature and concentration of cross-linking agent N,N"-methylenebisacrylamide (MBAAm). Results confirmed that swelling and dissolution rates of the SA/PAM hydrogel were increased when the temperature of the water was increased or the amount of MBAAm was decreased. When water temperature was increased, ionic crosslinks became unstable and amide bonds were broken due to hydrolysis, causing the hydrogel to rapidly dissolve in the hot water. Also, after the amount of MBAAm was decreased, ionic crosslinks became dominant and SA/PAM hydrogel became more vulnerable to hot water. Here, we analyzed the dissolution rate of hydrogel following temperature and MBAAm density changes. We also developed a selectively dissolvable water-blocking hydrogel that could be stable in cold water and become dissolved quickly in hot water.

백내장수술후 발생한 안내염의 임상적 고찰

최광주(Gwang Ju Choi),윤길중(Gil Joong Yoon),나경수(Kyeong Soo Na) 대한안과학회 1996 대한안과학회지 Vol.37 No.6