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육계에서 sulfathiazole 경구투여 후 혈장 및 조직내 잔류량
서형석 ( Heyng Seok Seo ),임정철 ( Jung Chul Lim ),허부홍 ( Boo Hong Hur ),권정택 ( Jung Taek Kwon ),김성문 ( Seong Moon Kim ),천희웅 ( Hee Woong Chun ),최인방 ( In Bang Choi ),김진상 ( Jin Shang Kim ) 한국가축위생학회 2002 韓國家畜衛生學會誌 Vol.25 No.3
The purposes of this study were to characterize the disposition of sulfathiazole(ST) and to investigate the effects of sodium bicarbonate on the disposition of ST in broiler chicks(2.5~3.0kg). Animals were given ST acutely(10~80mg/kg, PO), and plasma, kidney, muscle, heart, liver and spleen samples were collected and analyzed for ST by high performance liquid chromatography. The plasma and tissue data was consistent with a one-compartment pharmacokinetic model. The drug is rapidly but incompletely(2.5~3.87%) absorbed with peak plasma and tissue levels being achieved within one hour after dosing. The plasma and tissue levels depended on drug dosage, and the descending order in concentration of ST was kidney>plasma>heart>muscle≥spleen≥liver from animals sacrificed at one hour after dosing. Moreover, significant positive correlations(r>0.9) existed between plasma and tissue levels of ST. In addition, sodium bicarbonate pretreatment decreased plasma level, indicating that an alkalinization stimulate the excretion of ST. Results of this study suggest that oral application of ST was rapidly absorbed and eliminated, and confirmed that tissue residues of ST can be estimated from plasma drug concentration in broiler chicks.