소아의 키 성장에 대한 성장호르몬의 치료효과

정은진,천부순,Cheong, Eunjin,Chun, Pusoon 대한약학회 2016 약학회지 Vol.60 No.4

Growth hormone (GH) is widely used to treat growth disorders in patients with either GH deficiency (GHD) or non-GHD. However, the effects of GH therapy are inconsistent. The aim of this study was to investigate the effect of growth hormone therapy on height in children and adolescents in South Korea. A retrospective clinical analysis was conducted using the electronic medical records of the subjects who started GH therapy between January 2013 and December 2014 at a teaching hospital located in Seoul, Korea. In order to evaluate the effect of GH therapy, the auxological parameters such as height, height standard deviation scores (SDS), and height velocity was analyzed according to the duration of treatment and baseline height SDS. A total of 428 subjects were analyzed. GH therapy improved height SDS in the subjects treated for no more than 1 year as well as more than 1 year (0.27 vs. 0.68, p=0.006). Height SDS gain was significantly greater in the subjects with lower height SDS than the subjects with higher one at baseline (1.22 for SDS < -2 vs. $-2{\leq}SDS$ < 0, p < 0.001; 1.23 for $-2{\leq}SDS$ < 0 vs. $0{\leq}SDS$, p < 0.001). Negative correlations were found between increase in height SDS after treatment and both baseline age and height SDS (r=-0.33 for age; r=-0.38 for height SDS, both p < 0.001).

ABCB1 유전적 다형성이 만성 골수성 백혈병 환자의 Imatinib 치료 반응에 미치는 영향: 체계적 문헌고찰 및 메타분석

하혜민,천부순,Ha, Hye Min,Chun, Pusoon 대한약학회 2016 약학회지 Vol.60 No.3

A growing number of studies have demonstrated that ABCB1 gene polymorphisms are associated with the variability of responses to imatinib. However, the effects of ABCB1 polymorphisms on imatinib response in chronic myeloid leukemia (CML) are inconsistent. The aim of the present study was to clarify the associations between ABCB1 polymorphisms and imatinib response in CML. A systematic literature review was performed. The databases of PubMed, Embase, and Cochrane Library were searched for all published studies from inception to December 2015. The following terms were used with functions of 'AND' and 'OR': 'chronic myeloid leukemia', 'CML', 'ABCB1', 'MDR1', 'polymorphism', 'SNP', and 'imatinib'. Using the Review Manager 5, odds ratios (ORs) were pooled to estimate the effect of ABCB1 polymorphisms on imatinib response in CML. The pooled analysis showed that ABCB1 2677 G allele was significantly associated with poor response to imatinib in African and Asian patients (GG vs TT, OR: 0.32, p<0.0001; GG+GT vs TT, OR: 0.44, p=0.0005). In subgroup analyses, African patients carrying ABCB1 1236 C allele exhibited higher risk for worse response, whereas Asian patients with 1236 C allele showed better response (CC+CT vs TT, OR: 0.41, p=0.008 for African; OR: 1.65, p=0.03 for Asian). There was no association between C3435T polymorphisms and imatinib response in African, Asian, and Caucasian CML patients.

조현병 및 조현정동장애 환자에서 항정신병약물에 의한 체중증가에 미치는 메트포르민의 영향: 체계적 문헌고찰 및 메타분석

신혜연,천부순,Sin, Hye Yeon,Chun, Pusoon 한국임상약학회 2018 한국임상약학회지 Vol.28 No.3

Background: In this systematic review and meta-analysis, the effect of metformin on weight loss was assessed to determine whether metformin should be recommended for the prevention or treatment of weight gain in patients receiving antipsychotic medication for the treatment of schizophrenia or schizoaffective disorder. Methods: The PubMed, Embase, and Cochrane Library databases were searched for all published randomized controlled trials (RCTs) from inception to June 2018. In addition, the references of relevant articles were also examined. Using Review Manager 5, the pooled estimates of the weighted mean difference (WMD) of the changes in body weight and body mass index (BMI) and the corresponding 95 % confidence intervals (CIs) were calculated. Results: The meta-analysis included 15 RCTs. The pooled analysis showed that compared with placebo, metformin led to significant reductions in body weight (WMD: -2.09, 95% CI: -2.59, -1.60; p<0.00001) and BMI (WMD: -0.90, 95% CI: -1.08, -0.72; p<0.00001). The effect of metformin on weight loss was greater in patients receiving olanzapine than in patients receiving clozapine (body weight, WMD: -2.39, 95% CI: -3.76, -1.02; p=0.0006 for olanzapine; -1.99, 95% C: -3.47, -0.51; p=0.009 for clozapine; BMI, WMD: -1.15, 95% CI: -1.74, -0.57, p=0.0001 for olanzapine; WMD: 0.76, 95% CI: -1.23, -0.28; p=0.002 for clozapine). Conclusion: Metformin can be recommended to manage olanzapine-induced weight gain in patients with schizophrenia or schizoaffective disorder. The magnitude of the reductionss in body weight and BMI implieds that the use of metformin to attenuate olanzapine-induced weight gain can minimize the risk of coronary heart disease.

Real-world Adverse Events Associated with Fluconazole and Itraconazole: Analysis of Nationwide Data Using a Spontaneous Reporting System Database

이유경,이정민,천부순,Lee, Yu gyeong,Lee, Jungmin,Chun, Pusoon Korean College Of Clinical Pharmacy 2022 한국임상약학회지 Vol.32 No.3

Objective: This study aimed to investigate the occurrence and types of the adverse events (AEs) associated with oral fluconazole and itraconazole and factors associated with specific types of AEs. Methods: We analyzed AEs reported by community pharmacies nationwide over 10 years using the Korea Adverse Event Reporting System database. Various AE terms were categorized into 18 types, and concomitant medications were classified by drug-drug interaction (DDI) severity. The relationship between the specific type of AE and age, sex, and number of concomitant medications was investigated using multiple logistic regression analysis. Results: A total of 879 AE reports of fluconazole and 401 reports of itraconazole were analyzed; of these reports, 321 and 83 reports of fluconazole and itraconazole, respectively, described concomitant drug administration categorized as DDI severity of contraindicated or major. Women had a higher risk of psychiatric AEs associated with fluconazole use (OR, 1.587; p=0.042). Polypharmacy increased the risk for psychiatric AEs (OR, 3.598; p<0.001 for fluconazole and OR, 2.308; p=0.046 for itraconazole). In dermatologic AEs, the mean age of patients who received itraconazole was lower than that of patients who received fluconazole (46.3±16.8 vs. 54.9±15.4; p<0.001). Co-administration of fluconazole with 1-3 drugs increased the risk of neurological AEs (OR, 1.764; p=0.028). Conclusion: When using fluconazole and itraconazole, psychiatric AEs should be noted, particularly in women and in case of polypharmacy; moreover, when fluconazole is co-administered with other drugs, attention should be paid to the occurrence of neurological AEs.

SLCO1B1 T521C가 스타틴에 의한 저밀도지단백 콜레스테롤 감소에 미치는 영향: 체계적 문헌고찰 및 메타분석

이영숙(Young Sook Lee),천부순(Pusoon Chun) 대한약학회 2018 약학회지 Vol.62 No.4

Increasing number of studies have examined the effect of SLCO1B1 T521C polymorphism on lipid-lowering efficacy of statin. This study was conducted to clarify the effect of SLCO1B1 T521C on the rate of statin-induced reduction in low-density lipoprotein cholesterol (LDL-C). The databases of PubMed, Embase, Ovid, and Cochrane Library were searched for all published studies from inception to April 2018. Using the Review Manager 5, the pooled estimates of the weighted mean difference (WMD) of the percent changes of LDL-C and corresponding 95% confidence intervals (CIs) were calculated. A total of 17 cohort studies were included in this meta-analysis. The percent reduction in LDL-C was slightly higher in the statin users carrying 521TT than in the users carrying 521CC (WMD: 2.41; 95% CI: 0.15, 4.67; p=0.04). Sim-ilarly, the carriers of 521TC achieved slightly higher reduction in LDL-C than the carriers of 521CC (WMD: 2.07; 95% CI: 0.79, 3.35; p=0.002). However, no significant difference in percent reduction was found between the carriers and non-carriers of the 521C allele (TC+CC vs TT, WMD: 0.87; 95% CI: -0.67, 2.41; p=0.27). These results imply that the SLCO1B1 T521C polymorphism has little or no effect on the rate of reduction in LDL-C following statin therapy.

건강기능식품의 Cytochrome P450에 대한 영향

신혜연(Hye Yeon Sin),천부순(Pusoon Chun) 대한약학회 2018 약학회지 Vol.62 No.2

Increasing evidence has shown the involvement of health functional foods (HFFs) in inhibition or induction of cytochrome P450 (CYP), affecting the pharmacokinetics of co-administered drugs. To optimize the use of HFFs, it is nec-essary to understand the effects of them on CYPs. In this review we summarize the findings from clinical and in vitro studies evaluating the effects of HFFs on CYPs. In in vitro studies, CYP2C9 and 3A4 were strongly inhibited by allicin in garlic, boswellia extract, fermented curcuma, licorice extract, pomegranate concentrate, and red yeast rice. Furthermore, CYP2C9 was suppressed by hydrolyzed soy extract, lycii fructus extract, and Rhus verniciflua extract. Moreover, red yeast rice strongly inhibited CYP2D6, whereas CYP 2C19 was strongly suppressed by garlic, licorice extract, lycii fructus extract, red yeast rice, and Rhus verniciflua extract. Meanwhile, ginkgo biloba leaf extract showed a potent inductive effect on CYP2C19. In clinical studies, the long-term consumption of ginseng or ginkgo biloba leaf extract caused moderate inductive effects on CYP3A, whereas intake of milk thistle extract led to a moderate inhibition of CYP2C9. Further clinical studies are needed to verify the effects of HFFs on CYPs.

새로운 사이클로프로필 뉴크레오사이드 유도체의 합성과 생리활성

강진아(Jin-Ah Kang),천부순(Pusoon Chun),문형룡(Hyung Ryong Moon) 대한약학회 2012 약학회지 Vol.56 No.4

Synthesis of novel cyclopropyl pyrimidine and purine nucleoside derivatives 2~8 with α-configuration was successfully accomplished using an epoxide-ring opening reaction, lactonization, a hydroboration-oxidation reaction and a Mitsunobu reaction as the key steps. Antiviral activities against HSV-1 and -2, HIV-1 and -2, coxsackie B1and B3 viruses and poliovirus were assayed. Three compounds 4, 7 and 8 exhibit cytotoxicity-derived antiviral activity only in HIV-1 and -2.

국내 류마티스 관절염의 처방 현황 분석

김윤숙(Yoonsook Kim),천부순(Pusoon Chun) 대한약학회 2019 약학회지 Vol.63 No.6

This study was conducted to analyze the prescription patterns of glucocorticoids and disease-modifying antirheumatic drugs (DMARDs) in the management of rheumatoid arthritis. A cross-sectional study was conducted using the claims data of the Health Insurance Review and Assessment Service-National Patient Samples-2016. A total of 4,147 patients were analyzed. About 38, 28, and 6% received triamcinolone, methylprednisolone, and hydrocortisone, whereas 65, 45, 30, and 20% received methotrexate, hydroxychloroquine, leflunomide, and sulfasalazine. A total of 369 patients received biological DMARDs and approximately 47% received tocilizumab or adalimumab. Most of the biological DMARDs were concurrently prescribed with synthetic DMARD, especially methotrexate. In case of injectable glucocorticoids, 84% of the repeated injections were given within 12 weeks after the previous injections. As for oral glucocorticoid cases, 48% were “low dose” and stopped within 3 months. Furthermore, 15% continued for more than 6 months and 20% were prescribed at high doses. This study found that the prescription patterns of DMARDs met with the guidelines of American College of Rheumatology (ACR) and European League Against Rheumatism (EULAR). However, in many cases of glucocorticoid uses, the dose was higher and the duration was longer than the recommendations of the guidelines. High doses and longterm use of glucocorticoids should be restrained to prevent serious side effects.

아스피린 및 디클로페낙나트륨 장용정의 분할 처방 현황

윤승원(Seung Won Yun),천부순(Pusoon Chun) 대한약학회 2023 약학회지 Vol.67 No.4

약학대학생들의 성격유형과 희망취업분야

최방선(Bangsun Choi),정현주(Hyunju Joung),천부순(Pusoon Chun) 대한약학회 2022 약학회지 Vol.66 No.3

This study was conducted to investigate the personality types and most desired career fields of pharmacy students. In this study, 31 first-year students, 28 third-year transfer students, and 32 fifth-grade students were analyzed, and 60.4% were female. Of 91 subjects, the introversion-sensing-thinking-judging (ISTJ) type was the most common, followed by introversion-sensing-thinking-perceiving (ISTP) and extraversion-sensing-thinking-judging (ESTJ). Thirty-five percent of first-graders, 42.9% of third-graders, and 53.1% of fifth-graders were extroverts and 64.5% of first-graders, 71.4% of thirdgraders, and 68.8% of fifth-graders belonged to the “sensing” personality type. Seventy-one percent of first-graders, 60.7% of third-graders, and 75% of fifth-graders belonged to the “thinking” type. Of 41 students wishing to work at community pharmacies, 51.2% were extroverts, 70.7% were “sensing,” 63.4% were “thinking,” and 51.2% were the “judging” type. Of 32 students who preferred hospital pharmacy, 40.6% were extroverts, 71.9% were “sensing,” 81.3% were “thinking,” and 53.1% were the “judging” type. Of 11 students wishing to work in pharmaceuticals, 36.4% were extroverts, 63.6% were “sensing,” 63.6% were “thinking,” and 72.7% were the “perceiving” type. Of seven students who preferred public institutions, 71.4% were introverts. When analyzing the correlation between personality types and the most desired career fields, no statistical significance was observed.