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채광조,라선영,오봉경,구자승,김영주,박찬일,박영년 대한간학회 2003 Clinical and Molecular Hepatology(대한간학회지) Vol.9 No.3(S)
Background/Aims: The intraductal growth (IG) type of cholangiocarcinoma has a better prognosis than the mass forming (MF) and periductal infiltrating (PI) types. Matrix metalloproteinase (MMP)-2 and MMP-9, regulated by tissue inhibitor of metalloproteinases (TIMP)-2 and TIMP-1, respectively, play important roles in the degradation of the basement membrane during tumor invasion. Alteration in MMPs and TIMPs may regulate the gross morphology of cholangiocarcinoma. Methods: MMP-2 and MMP-9 were analyzed in 22 cholangiocarcinomas with fresh tissue using zymography and real time quantitative RT-PCR, and expressions of MMP-2, MMP-9, TIMP-1 and TIMP-2 were evaluated in 76 cholangiocarcinomas by immunohistochemistry. Results: The total MMP-2, active 62 kDa MMP-2, and MMP-2 mRNA increased 5.6 and 8.0 times, 5.3 and 7.9 times, and 3.1 and 6.8 times in the MF and PI types, respectively, compared to the IG type. The MMP-9 was present in the proform without activation and revealed no significant difference in relation to the gross types. The balanced expressions of MMP-2/TIMP-2 and MMP-9/TIMP-1 were significantly decreased in the MF and PI types, compared to the IG type. In the non-neoplastic liver, the expressions of MMP-2 and MMP-9 were very low without active form. Conclusions: The activities of MMP-2 and loss of balanced expressions of MMP-2/TIMP-2 and MMP-9/TIMP-1 were increased in the MF and PI types with invasive growth compared to the IG type with a preserved basement membrane. MMP-2 and imbalance between MMPs and TIMPs are suggested to play important roles in invasive growth related to the gross type of cholangiocarcinoma
대한간학회지 제8차 춘계학술대회 초록집 : 포스터 발표 ; 간의 이형성 결절에서 틸로미어 길이 감소와 틸로머레이즈의 재활성
오봉경 ( O Bong Gyeong ),채광조 ( Chae Gwang Jo ),박찬일 ( Park Chan Il ),김경식 ( Kim Gyeong Sig ),이우정 ( Lee U Jeong ),한광협 ( Han Gwang Hyeob ),전재윤 ( Jeon Jae Yun ),문영명 ( Mun Yeong Myeong ),박영년 ( Park Yeong Nyeon 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.2(S)