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GPS/ GLONASS 통합 수신용 RF 전단부의 설계 및 제작
주재순,염경환,이상정 한국전자파학회 2001 한국전자파학회논문지 Vol.12 No.4
GPS(Global Positiong System)와 GLONASS(GLObal NAvigation Satellite System) 는 위치와 시각을 제공하는 기초 기술이며 항법 분야, 측지분야, 자세 측정 및 제어 분야 등 그 응용분야가 다양하다. 그러나 GPS나 GLONASS는 각기 제한된 가시 위성의 수로 인해 정확한 항법 해를 얻는데 어려움이 있으며, 또한 하나의 항법 시스템만을 이용하는 경우 의존도가 너무 높아지게 되어 전략적인 측면에서도 불리하다. 이러한 측면에서 GPS와 GLONASS 의 통합수신은 보다 정확한 항법 해를 구할 수 있고 보다 나은 시스템의 안정도를 가져올 수 있다. 이를 목적으로 GPS/GLONSS 통합 수신용 RF 전단부를 130$\times$80 mm$^2$의 PCB상에 구현하였고 실제 시스템에 적용 가능한지를 측정하였으며 GLONASS 수신기의 one chip화의 가능성을 검토하였다. GPS(Global Positioning System) and GLONASS(GLObal Navigation Satellite System) are basic technologies providing the information of the position and the time, and they have various applications such as navigation, survey, control, and so on. However, each GPS and GLONASS has limited number of visible satellites, and, from the view of strategy, it is undesirable to be heavily dependent on only one system. Thus, GPS/GLONASS combined receiver became required to obtain more precise navigation and system stability. In this paper, the RF front end of GPS/GLONASS combined receiver was fabricated on 130$\times$80 $\textrm{mm}^2$ PCB(Printed Circuit Board), and its system application was shown finally one chip possibility of GLONASS receiver is studied.
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Ultrasonography-guided transplantation facilitates perineural delivery of stem cells
김상범,주재순,홍영빈,최병옥 한국통합생물학회 2015 Animal cells and systems Vol.19 No.4
Treatment options for peripheral neuropathy are very limited. In order to develop a therapeutic strategy using stem cell therapy for the peripheral nervous system, we explored the feasibility of a new delivery method. Using ultrasonographyguided transplantation, human mesenchymal stem cells (hMSCs) were delivered into the perineural region of small rodent models. An optical imaging system revealed that hMSCs stained with CFSE or PKH26 reside for a week posttransplantation in both the mouse and rat. Immunofluorescence analysis of tissues revealed the presence of transplanted hMSCs in the perineural region of mice. At the end of the experiments, no behavioral or phenotypic abnormalities were observed. In addition, H&E and toluidine blue staining showed the integrity of the sciatic nerve after transplantation. This is the first study, to the best of our knowledge, to deliver cells into the perineural region under ultrasonography guidance. Since hMSCs can reside for a considerable time at a transplanted site, an anti-inflammatory efficacy of the transplanted hMSCs can be expected in the perineural region. In conclusion, we established a new administration route for inflammatory peripheral neuropathy without complications, and this may be used for delivery of chemical drugs or stem cells.
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최유리,정성철,신진희,유소영,이지수,주재순,이진호,홍영빈,최병옥 대한의학유전학회 2015 대한의학유전학회지 Vol.12 No.1
Purpose: Charcot-Marie-Tooth disease (CMT) is a peripheral neuropathy mainly divided into CMT type 1 (CMT1) and CMT2 according to the phenotype and genotype. Although molecular pathologies for each genetic causative have not been revealed in CMT2, the correlation between cell death and accumulation of misfolded proteins in the endoplasmic reticulum (ER) of Schwann cells is well documented in CMT1. Establishment of in vitro models of ER stress-mediated Schwann cell death might be useful in developing drug-screening systems for the treatment of CMT1.Materials and Methods: To develop high-throughput screening (HTS) systems for CMT1, we generated cell models using transient expression of mutant proteins and chemical induction. Results: Overexpression of wild type and mutant peripheral myelin protein 22 (PMP22) induced ER stress. Similar results were obtained from mutant myelin protein zero (MPZ) proteins. Protein localization revealed that expressed mutant PMP22 and MPZ proteins accumulated in the ER of Schwann cells. Overexpression of wild type and L16P mutant PMP22 also reduced cell viability, implying protein accumulation-mediated ER stress causes cell death. To develop more stable screening systems, we mimicked the ER stress-mediated cell death in Schwann cells using ER stress inducing chemicals. Thapsigargin treatment caused cell death via ER stress in a dose dependent manner, which was measured by expression of ER stress markers. Conclusion: We have developed genetically and chemically induced ER stress models using Schwann cells. Application of these models to HTS systems might facilitate the elucidation of molecular pathology and development of therapeutic options for CMT1.
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