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      • SCOPUSKCI등재

        위결핵

        선덕재(Duk Jae Shun),박충기(Choong Kee Park),임규성(Kyu Sung Rim),박명석(Myoung Suk Park),김진민(Jin Min Kim),주상언(Sang On Ju) 대한소화기학회 1986 대한소화기학회지 Vol.18 No.2

        Gastric tuberculosis is a rare disease, and it is very difficult to diagnose correctly in early phase. We experienced a case of gastric tuberculosis which was developed at 14 months after subtotal gastrectomy for stomach cancer in 55 years old male patient.

      • KCI등재후보

        간세포암 환자에서 DNase , RNase 및 Rnase inhibitor 측정의 의의

        계세협(Sea Hyub Kae),정유선(Yoo Sun Chung),장현주(Heon Ju Jang),정선화(Sun Wha Jung),김용태(Yong Tae Kim),강승식(Seung Sik Kang),이진(Jin Lee),곽상택(Sang Taek Kwak),주상언(Sang Aun Joo),유재영(Jae Young Yoo) 대한내과학회 1998 대한내과학회지 Vol.54 No.5

        N/A Objective Activities of nucleases (acid DNase and neutral RNase) and RNase inhibitor 1mown to be involved in carcinogenesis and suppression of cancer were determined in cancer tissue, serum and ascitic fluid of patients with hepatocellular carcinoma and were compared with those of the controls. Also studied were nucleases and RNase inhibitor isolated from hepatocellular carcinoma tissue and ascitic fluid of the cancer patients to evaluate the properties and interactions between them. Method: Activities of nucleases and RNase inhibitor were measured in cancer tissue, serum and ascitic fluid of patients with hepatocellular carcinoma by ultraviolet spectrophotometry. Nucleases and RNase inhibitor were isolated from hepatocellular carcinoma tissue and ascitic fluid of the cancer patients by DEAE-cellulose column chromatography. As controls, normal tissue of the cancer patients, serum of healthy persons and ascitic fluid of cirrhotic patients were used. Result: Activities of DNase, RNase and RNase inhibitor were significantly increased in hepatocellular carcinoma tissue. DNase activity was not detected, RNase activity was increased and RNase inhibitor activity was unchanged in both serum and ascitic fluid of the hepatocellular carcinoma patients. DNase was isolated as a single enzyme and RNase as seven isozymes from the hepatocellular carcinoma tissue. The DNase isolated preferentially cleaved ds DNA over ss DNA and was endonuclease in nature (majority of hydrolytic products of DNA by the DNase were oligodeoxyribonucleotides). Of seven RNase isozymes isolated from the hepatocellular carcinoma tissue, isozyme I exhibited nonsecretory nature of RNase and other six isozymes secretory nature of the enzyme. Activity of RNase isozyme V was greatly increased and the activity of inhibitor complexed with the isozyme V was also increased. RNase in ascitic fluid of the cancer patient was separated into four isozymes, of which isozyme I exhibited mixed form of secretory and nonseretory nature and greatly increased in its activity. RNase isozyme V isolated in the hepatocellular carcinoma tissue was not detected in the ascitic fluid, Conclusion: The use of the nucleases and the inhibitor in the cancer tissue as biochemical markers for the hepatocellular carcinoma was suggested. RNase was released into the body fluid from the cancer tissue and could be used as a diagnostic marker for the hepatocellular carcinoma. An important rale of the DNase in carcinogenesis of the liver was suggested. RNase isozyme V was limited in the cancer tissue and RNase isozyme I and V and inhibitors associated with these isozymes might be involved in carcinogenesis processes, suppression of cancer and maintenance of tocellular carcinoma through their interactions.

      • SCOPUSKCI등재

        소화성 궤양에 대한 Famotidine (Gasterⓡ) 의 임상효과의 검토

        박충기,임규성,주상언 대한소화기내시경학회 1987 Clinical Endoscopy Vol.7 No.1

        The aim of the investigation was to study the efficacy and safety of Famotidine (Gaster), a new, potent, histamine H-receptor antagonist. The Famotidine (40 mg p.o.h.s) was administered to 22 patients with 33 peptic ulcers for 4 weeks. Follow up checking was done at 2 week and 4 week by endoscopy and physical examination. All patients were carefully evaluated at regular intervals for adverse drugh reactions by clinical and laboratory examinations. By the end of study, 97% of the ulcers were healed by endoscopically and rapid and complete relief of epigastric pain was observed in all patients. Famotidine treatment was well tolerated and no alterations in laboratory tests were noted. Therfore, Famotidine was proved effective in the treatment of peptic ulcers (especially multiple ulcers) and was well tolerted on the short-term basis.

      • KCI등재후보

        담낭의 결절성 다발 동맥염 1예

        조미경,윤돈영,함상수,한춘호,손주현,곽상택,주상언,송창용,김성,박혜림 대한내과학회 1992 대한내과학회지 Vol.42 No.6

        저자들은 우상복부동통 및 발열을 주소로 내원한 63세 남자 환자에서 수술전에는 전혀 예상할 수 없었으나 진단 목적으로 시행한 담낭절제술후, 병리 조직검사상 담낭의 결절성 다발동맥염으로 진단된 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Polyarteritis nodosa is one of the necrotizing vasculitis, characterized by necrotizing panarteritis in small and medium sized arteries. Various organ may be involved but isolated panarteritis of gallbladder is rare. We experienced a case of PAN of gallbladder, presenting as acute cholecystitis, confirmed by biopsy and report this with a review of literatures.

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