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배양된 흰쥐 뇌간 신경세포에서 5-Hydroxytryptamine 흡수에 대한 각종 전통 생약 추출물의 억제 효과
조현미,정전섭,이태희,손건호,서홍원,송동근,김영희,Cho, Hyun-Mi,Jung, Jun-Sup,Lee, Tae-Hee,Son, Kun-Ho,Suh, Hong-Won,Song, Dong-Keun,Kim, Yung-Hi 한국생약학회 1995 생약학회지 Vol.26 No.4
Crude methanolic(80%) extracts from 109 kinds of traditional herbal drugs were randomly screened for inhibitory effects on 5-hydroxytryptamine(5-HT) uptake in primary cultured rat brainstem neurons. Rat brainstem neurons were cultured from embryonic day 14, and maintained for 7-9 days in vitro. Clomipramine (500 nM), a reference drug, decreased 5-HT uptake to 16% of control values. Of the 109 herbal drugs screened, Citri immaturi Pericarpium(靑皮), Coptidis Rhizoma(黃蓮), Cnidii Rhizoma(土川芎) showed the most potent 5-HT uptake inhibiting activities. These herbal drugs, at the concentration of $10{\;}{\mu}g/ml$, inhibited 5-HT uptake 69, 69, and 57% respectively, when inhibition(%) was expressed as a relative value compared to the 500 nM clomipramine-induced inhibition.
조현미(Cho Hyunmee),권수혜(Kwon Suhye),이연향(Lee Younhyang),김윤정(Kim Yunjeong),강정미(Kang Jungmi) 한국노인간호학회 2020 노인간호학회지 Vol.22 No.2
Purpose: This phenomenological study was done to identify clinical nurses experiences of safety management with older patients. Methods: Data were analyzed using Colaizzi s phenomenological six step method. Data collected from July 27 to December 1, 2017, were from face-to-face in-depth interviews with seven nurses who had worked at one general hospital for more than five years. Data collection was done until data saturation was reached. Results: This study results were comprised of four categories and nine clusters of themes. The four categories were: “Increasing burden in the management of older patients”, “Unsettling feelings of fear and guilt from unexpected safety accidents”, “Shift to active coping”, and “Expectations regarding improvement of safety management for older patients” Conclusion: The results of this study show that for clinical nurses to provide safety management for older patients, it is necessary to have a sufficient number of nursing staff, to understand the unique characteristics of elders, and to establish facilities that older patients can use safely and conveniently. In addition, this study is significant for the nursing community as it provides an improved understanding of safety management for older patients from the nurses point of view and thereby, suggests that there is a need for education and improvement in the work capability to provide care to elders. Furthermore, the study results are also politically significant as evidence to establish standards for expanding the number of nursing staff and safety management infrastructure.
알코올 의존증 남편을 둔 여성 배우자로 살아감에 대한 생애사 연구
조현미(Cho Hyunmee),조은주(Cho Eunju),장유나(Jang yoona) 학습자중심교과교육학회 2022 학습자중심교과교육연구 Vol.22 No.8
목적 알코올 의존증 남편을 둔 여성 배우자로 살아감에 관한 본질적 의미를 파악하여 이들에게 필요한 전문적 개입의 실천적 방안 마련을 위한 기초자료를 제시하고자 본 연구를 시행하였다. 방법 질적 연구방법 중 하나인 생애사적 연구 방법을 이용하였다. 연구 참여자는 알코올 의존증 남편을 둔 52세 여성 배우자 1인이다. 주제 중심적 생애사 자료 수집 방법으로 심층면담을 시도하였고 참여자 면담 시 연구 참여 동의서를 받았다. 자료의 분석은 Mandelbaum이 제시한 생애사 분석 틀인 삶의 차원, 삶의 전환점, 적응 차원에 따라 참여자의 생애사를 분석하고 생애사 문장을 구성하였다. 결과 자료의 분석결과 삶의 영역은 ‘아버지의 술 문제로 불안정한 어린 시절’, ‘울타리가 되어주지 않는 부모를 원망함’, ‘어머니의 자리를 자신이 채움’, ‘하고 싶은 일을 참고 살아 옴’, ‘부모를 바라보며 자신은 다른 부모가 되리라 다짐함’, ‘남편의 술 문제로 고통스러운 결혼생활’로 나타났다. 또한 삶의 전환점 영역은 ‘엄마의 부재가 사회로부터 버림받은 느낌을 줌’, ‘동기들과 동떨어진 삶의 방향’, ‘다시 삶을 붙들어 준 신앙’, ‘남편의 눈물에서 변화의 가능성을 발견함’, ‘나를 개방하며 삶의 태도가 바뀜’으로 나타났다. 마지막으로 적응 영역은 ‘자기 가치를 회복하고 표현하는 삶을 살게 됨’, ‘서로를 이해하며 건강한 가족이 되는 길로 한 걸음 나아감’, ‘감사의 제목들을 발견하고 내적 성장을 이루어 감’으로 나타났다. 결론 본 연구에서 시도한 알코올 의존증 남편을 둔 여성 배우자가 경험하는 생애에 대한 분석을 통해 이들이 경험해 온 삶의 궤적에는 자기 자신에 대한 부정적 내재화, 우울감 및 공허함이 내재되어 있음을 확인할 수 있었다. 이러한 결과를 통해 알코올 의존자 가정의 여성 배우자가 경험하는 다양한 어려움에 대한 심도 깊은 이해를 제공하였으며 알코올 의존자와 그 배우자 및 가족의 회복과 건강가정 유지를 위한 전문적 개입의 실천적 방안 마련을 위한 기초자료를 제시하였다고 보여진다. Objectives This study was conducted to understand the essence of what it is like to live as a wife of an alcoholic and to provide baseline data to help develop protocols for professional interventions. Methods Life history research, an example of a qualitative study method, was utilized. The study participant was a 52-year-old female spouse of an alcoholic. In-depth interviews were conducted to gather data on her life history. Consent was acquired prior to the initiation of the interview. Data analysis were assessed based on the life history research frame presented by Mandelbaum, which included life dimensions, turning point, and adaptations. Life history sentences were constructed. Results Analysis were identified, the realms of life were ‘an unstable childhood due to father s alcohol problem’, ‘resented her parents for not being a fence’, ‘filled mother’s place herself’, ‘lived by enduring what I want’, ‘vowed to herself that will be a better parent than parent’, and ‘painful marriage life due to her husband s drinking problem’. Life turning points included ‘felt deserted due to her mother’s absence by society’, ‘a way of life apart from classmates’, ‘faith that sustains life’, ‘found possibilities of change in her husband’s tears’, ‘changed in the attitude towards life by opening myself’. Adaptations were ‘living a life that restores self-worth and expressed’, ‘one step better to be a healthy family in which understandings each other’, ‘discovered gratitude and achieved internal growth’. Conclusions An analysis of the life of a female spouse of an alcoholic revealed that the trajectory of their lives included negative self-internalization, depression, and emptiness. This study provided a detailed understanding of the various difficulties that occur to the female spouse in a family with alcoholic and went further to provide baseline data to help develop protocols for professional interventions to restore and protect a healthy family for the alcoholic and spouse.
조현미(Cho, Hyeonmi) 한국실내디자인학회 2013 한국실내디자인학회논문집 Vol.22 No.1
The primary purpose of this research was to set up the standard guidelines for the planning of interior architectural environments of the detention facilities at the Korean Police Stations. By visit-studying the actual interior environmental conditions of 5 different kinds’ domestic Correcting Facilities and 5 domestic police detention facilities and 2 foreign police detention facilities, comparing them to the existing Korean correctional institutions’ cell facilities, that the strengths and weaknesses had been analyzed to extract the main concepts and the planning scheme for the Standard Korean Police Detention Facilities. By reserching the National human Right Commitee’s Anual Reports, three different indexes were picked out for those analysis : the Environmental control index, the Detention Service support index, the Environmental support index. These three indexes will be used as Key factors for the planning of interior architectural environments of the detention facilities at the Korean Police Stations.: ①the Environmental control index to establish the Space Program, the Spatial Hierarchy and the horizontal & vertical Security Blocks, ②the Detention Service support index for the central Environmental Control & Security System, the Secured Privacy for both detainees & police offices, ③the Environmental support index for the gender-respected segregation of cell zones, the psychological & physical safety design factors, the construction standards of all rooms in a detention facility. The result of this study should be used as the guidelines for “The Standard Plans and Regulations for the Korean Police Detention Facilities” to respect fundamental human rights.