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조유경 ( Jo Yu Gyeong ),최명규 ( Choe Myeong Gyu ),한혜원 ( Han Hye Won ),김세희 ( Kim Se Hui ),이인석 ( Lee In Seog ),김상우 ( Kim Sang U ),정인식 ( Jeong In Sig ) 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<목적> 유동식부하검사는 기능성소화불량증 환자에서 위적응과 감각능을 반영한다고 보고되었다. 연자들은 건강인과 환자를 대상으로 고칼로리 유동식부하검사를 시행하여 검사의 의의를 조사하였다. <방법> 위절제환자, 기능성소화불량증환자, 건강대조군에게 3분 간격으로 유동식(ensure, 1 kcal/ml) 67.5 ml (22.5 ml/min)을 최대한 먹을 수 있을 때까지 마시도록 하였다. 3분 간격으로 오심, 포만감, 상복부 불쾌감/통증의 3 증상을 시각적
조유경 ( Jo Yu Gyeong ),최명규 ( Choe Myeong Gyu ),김세희 ( Kim Se Hui ),이인석 ( I In Seog ),김상우 ( Gim Sang U ),정인식 ( Jeong In Sig ),이상열 ( I Sang Yeol ),최석채 ( Choe Seog Chae ),설상영 ( Seol Sang Yeong ) 대한소화기학회 2004 대한소화기학회지 Vol.43 No.3
Background/Aims: It is unknown whether the prokinetics improve the quality of life in patients with functional dyspepsia. Thus, we evaluate the effect of the mosapride, selective 5-HT4 agonist, on the symptom and life quality of patients with functional dyspepsia using the Nepean dyspepsia index-Korean version (NDI-K), a reliable and validated disease-specific quality of life questionnaire. Methods: A single, open trial was performed in 129 patients with functional dyspepsia. Patients were received mosapride 5 mg t.i.d before each meal for 4 weeks. The symptoms and quality of life were measured with the NDI-K at baseline and 4 weeks. The responsiveness of the NDI-K was evaluated by correlation with symptom scores. Results: All the 15 symptom scores and the dyspepsia score decreased after treatment (p<0.05). The total symptom score decreased from 60.9±25.8 to 24.7±20.4 (p=0.001). Correlations were observed between the total symptom score and the NDI-K score (r=0.47, p=0.001), and between the total symptom score and each score in 5 subscales (r=0.25-0.44, p=0.001). The NDI-K score was significantly increased in the effective group whose dyspepsia score decreased more than 50% of the score at baseline, compared with that of ineffective group. Any significant adverse effect and prolongation of QT interval were not occurred in all patients. Conclusions: A prokinetic drug, mosapride improves the symptoms and the quality of life in patients with functional dyspepsia. (Korean J Gastroenterol 2004;43:160-167)
당뇨병 환자에서 발생한 Cerivastatin에 의한 횡문근 융해증 3예
이성수 ( Lee Seong Su ),조유경 ( Jo Yu Gyeong ),김해림 ( Kim Hae Lim ),박훈준 ( Park Hun Jun ),박만원 ( Park Man Won ),최민석 ( Choe Min Seog ),이강우 ( Lee Gang U ),장윤식 ( Jang Yun Sig ),방병기 ( Bang Byeong Gi ) 대한신장학회 2001 Kidney Research and Clinical Practice Vol.20 No.6
Cerivastatin is novel HMG-CoA reductase inhibitors. Clinical trials showed no significant differences of serum creatine kiase between cerivastatin and placebo, and cerivastatin-induced myopathy was rarely reported. This beneficial effect of cerivastatin is thought to be related to the the dual pathway metabolism by hapatic CYP3A4 and 2C8. We here report three cases of rhabdomyolysis which is associated with cerivastatin therapy. Two patients had diabetes mellitus, and received cerivastatin( 0.8 mg/day) for treating hyperlipidemia and the other patient had chronic renal failure due to diabetic nephropathy and has maintained peritoneal dialysis and received cerivastatin(0.4 mg/day). Within one month of cerivastatin treatment, those patients experienced myalgia or muscle weakness. At that time, laboratory findings including muscle enzyme level, and bone scan finding were compatible with rhadomyolysis. Under the impression of cerivastatininduced rhabodmyolysis, cerivastatin was withdrwan, and conventional treatment for rhabdomyolysis was started. Clinical course was uneventful, and these patients were discharged with good general condition. In conclusion, cerivastatin is regarded as a safe drug as compared with other statins, but it also causes rhabdomyolysis. Careful history taking and regular follow-up of muscle enzyme levels would be necessary to detect cerivastatin-induced rhabdomyolysis.
한국인에서 Interleukin 1β 유전자다형성에 따른 위산분비능
이인석 ( Lee In Seog ),한혜원 ( Han Hye Won ),조유경 ( Jo Yu Gyeong ),김세희 ( Kim Se Hui ),이수민 ( Lee Su Min ),이학성 ( Lee Hag Seong ),김상우 ( Kim Sang U ),최명규 ( Choe Myeong Gyu ),채현석 ( Chae Hyeon Seog ),김재광 ( Kim Ja 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<배경> IL-1β는 Helicobacter pylori 감염 후 증가되는 염증물질로서 IL-1β의 유전자다형성은 위내저산증과 연관 있는 것으로 알려져 있다. 저자는 IL-1β 유전자다형성에 따른 위산분비능에 대하여 연구하였다. <방법> 2001년 9월-2003년8월까지 강남성모병원 소화기내과를 방문한 환자 중 지원자를 대상으로 IL-1β -511,-31 및 IL-1RN 유전자다형성여부를 조사하고, 상부위장관내시경, 혈중 gastrin/ pepsinog
한국인에서 분리된 Helicobacter pylori 균주의 항생제 내성율의 변화와 내성 기전
한혜원 ( Han Hye Won ),정인식 ( Jeong In Sig ),이학성 ( Lee Hag Seong ),이수민 ( Lee Su Min ),이인석 ( Lee In Seog ),조유경 ( Jo Yu Gyeong ),김세희 ( Kim Se Hui ),김상우 ( Kim Sang U ),최명규 ( Choe Myeong Gyu ) 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<목적> 항생제에 대한 내성은 H. pylori 제균 실패의 중요한 원인이다. 저자는 한국인에서 분리된 H.pylori 균주에서 clarithromycin과 metronidazole에 대한 내성률의 변화와 내성 기전을 조사하였다. <방법> 2002년 8월부터 2003년 7월까지 H. pylori 감염 양성인 45명의 환자를 대상으로 과거 H.pylori 치료여부를 확인하고, 균배양을 시행하였다. 배양된 H. pylori에서 metronidazole과 c