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두개내압 상승과 중추 α-adrenoceptor와의 관계
도성신,김형근,조광룡 대한신경외과학회 1983 Journal of Korean neurosurgical society Vol.12 No.1
Urethane 마취가토에서 경뇌막외강내에 삽입한 ballon을 통한 가압 및 두개내압 기록 방법에 의하여 내압상승에 따른 혈압상승에 관여하는 α-adrenoceptor의 성질을 구명코자 하였다. 1) 두개내압의 상승에 따라 현저한 혈압상승이 나타났다. 2) B-HT는 혈압하강 및 심박감소를 일으켰고, 내압상승에 따른 혈압상승을 현저하게 억제하였다. 3) Piperoxan은 내압상승에 따른 혈압상승을 강화시켰다. 4) Piperoxan은 B-HT의 혈압하강 및 심박감소 작용에 길항하였고, 내압상승에 따른 혈압상승작용에 대한 B-HT의 억제작용에도 길항하였다. 5) Prazosin은 내압상승에 따른 혈압상승작용에 거의 영향을 미치지 못하였다. 6) Prazosin은 B-HT의 혈압하강, 심박감소작용 및 내압상승에 따른 혈압상승에 대한 억제작용 모두에 전혀 영향을 미치지 못하였다. 이상의 실험성적으로 내압상승에 따른 혈압상승에는 중추 α-adrenoceptor가 중요한 역할을 하며 그 성질은 α₂- 형일 것으로 추론하였다. The author attempted to clarify the nature of α- adrenoceptors in relation to the pressor response to the increased intracranial pressure (ICP) in urethane anesthetized rabbits, using the epidural balloon method. 1) The blood pressure increased in parallel with the raised ICP which was made by gradual inflation of the balloon. 2) B-HT 920, an α₂- agonist, which elicited depressor and bradycardiac responses in normal rabbits inhibited markedly the pressor response to the raised ICP. 3) Piperoxan, an α₂- antagonist, potentiated the pressor response to the raised ICP. 4) Piperoxan antagonized the depressor and bradycardiac responses by B-HT 920 as well as the inhibitory effect of B-HT 920 on the pressor response to the raised ICP. 5) The pressor response to the raised ICP were not affected at all by prazosin, an α₁- antagonist. 6) Neither the depressor and bradycardiac responses by B-HT 920 itself nor the inhibitory effect of B-HT 920 on the pressor response to the raised ICP were significantly affected by prazosin. It is inferred from these observations that the central α-adrenoceptors play an important role in producing the pressor response to the raised ICP and that the receptors involved here seems to be of α₂- type.
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이규빈,최장규,박영은,정건호,권도희,조광룡,천충기,장동칠,진용익,Lee, Gyu-Bin,Choi, Jang-Gyu,Park, Young-Eun,Jung, Gun-Ho,Kwon, Do-Hee,Jo, Kwang-Ryong,Cheon, Chung-Gi,Chang, Dong Chil,Jin, Yong-Ik 한국농림기상학회 2022 한국농림기상학회지 Vol.24 No.3
Due to abnormal weather conditions caused by climate change, natural disasters and damages are gradually increasing around the world. Global climate change as accompanied by warming is projected to exert adverse impact on production of potato, which is known as cool season crop. Even though, role of potato as a food security crop is expected to increase in the future, the climate change impacts on potato and adaption strategies are not sufficiently established. Therefore, this study was conducted to analyze the damage pattern of potatoes due to high temperature treatment and to evaluate the response of cultivars. T he high temperature treatment (35~38℃) induced heat stress by sealing the plastic house in midsummer (July), and the quantity and quality characteristics of potatoes were compared with the control group. T otal yield, marketable yield (>80 g) and the number of tubers per plants decreased when heat treatment was performed, and statistical significance was evident. In the heat treatment, 'Jayoung' cultivar suffered a high heat damage with an 84% reduction in yield of >80 g compared to the control group. However, in Jopung cultivar, the decrease was relatively small at 26%. Tuber physiological disturbances (Secondary growth, Tuber cracking, Malformation) tended to increase in the heat stress. Under heat conditions, the tubers were elongated overall, which means that the marketability of potatoes was lowered. T he tuber firmness and dry matter content tended to decrease significantly in the heat-treated group. T herefore, the yield and quality of tubers were damaged when growing potatoes in heat conditions. T he cultivar with high heat adaptability was 'Jopung'. T his result can be used as basic data for potato growers and breeding of heat-resistant cultivars.
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