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한국인 정신분열병 환자의 지연성 운동장애와 $CYP2D6^*4$ 및 $CYP2D6^*10$ 다형성들의 연합에 대한 고찰
우성일,강동우,서한길,김봉조,이인상,정근화,박소영,정치영,이환철,정경천,손진욱,Woo, Sung-Il,Kang, Dong-Woo,Seo, Han-Gil,Kim, Bong-Jo,Lee, In-Sang,Jeong, Geun-Hoa,Park, So-Young,Jung, Chi-Yeong,Lee, Hwan-Cheol,Jeong, Kyeong-Cheon,Sohn, 대한생물정신의학회 2000 생물정신의학 Vol.7 No.2
P450 CYP2D6 enzyme(=debrisoquine hydroxylase) is known to metabolize many neuroleptics and some genetic polymorphisms in the CYP2D6 gene were reported to be associated with tardive dyskinesia(TD). We investigeted the association of two genetic polymorphisms in the CYP2D6 gene, $CYP2D6^*4$ and $CYP2D6^*10$, with TD in Korean schizophrenic subjects. Subjects consisted of 71 Korean schizophrenics and TD was evaluated using the Abnormal Involuntary Movement Scale (AIMS). There were no statistically significant differences in the demographic variables of age, male to female percentage and the current antipsychotic(CPZ equivalent) dose between the group with TD and the group without TD. But the duration of antipsychotic drug exposure was significantly higher in the group without TD(p=0.000, by independent t-test). The mean AIMS score in the group with TD was $11.2{\pm}6.6$(S.D.). Genotypings for the presence of $CYP2D6^*4$ and $CYP2D6^*10$ were done using PCR amplifications and endonuclease digestions. There were no statistically significant genotypic and alleleic associations between TD and $CYP2D6^*4$(by chisquare tests), and between TD and $CYP2D6^*10$(by chi-square tests). These results indicate that the $CYP2D6^*4$ and $CYP2D6^*10$ polymorphisms have no significant roles in the causation of TD.
진행성 위암에서 종양 맥관형성이 예후인자로서의 가치를 가지는가?
박정우(Jeong-Woo Park),이민효(Min-Hyo Lee),주정일(Jeong-Il Joo),주영태(Young-Tae Ju),정치영(Chi-Young Jeong),하우송(Woo-Song Ha),박순태(Soon-Tae Park),최상경(Sang-Kyung Choi),홍순찬(Soon-Chan Hong),권수인(Soo-In Kwon),이영준(Young-Jo 대한외과학회 1999 Annals of Surgical Treatment and Research(ASRT) Vol.57 No.3
김가정(Ka-Jeong Kim),정치영(Chi-Young Jeong),정상호(Sang-Ho Jeong),주영태(Young-Tae Ju),정은정(Eun-Jung Jung),이영준(Young-Joon Lee),최상경(Sang-Kyung Choi),하우송(Woo-Song Ha),박순태(Soon-Tae Park),홍순찬(Soon-Chan Hong) 대한외과학회 2011 Annals of Surgical Treatment and Research(ASRT) Vol.80 No.1
Purpose: With the advancement of laparoscopic instruments and accumulation of surgical technique, laparoscopic liver resection is currently performed for various benign and malignant liver diseases. However, controversies still remain over laparoscopic liver resection for malignant liver diseases including HCC and its oncologic safety is yet to be established. This study aims at determining the safety, feasibility and short-term oncologic outcomes of laparoscopic liver resection performed for HCC. Methods: From July 2008 to March 2010, laparoscopic liver resection was performed at our hospital on a total of 45 patients with various benign and malignant liver diseases. Among these 45 patients, 16 patients diagnosed with HCC were reviewed retrospectively. Results: The mean age of the patients was 59.25, comprising 11 male patients (68.8%) and 5 female patients (31.2%). The location of tumor was left lateral in 7 cases, 4 cases in segment 6, 2 cases in segment 7, 2 cases in segment 5, 1 case in segment 4 and 1 case in caudate lobe. Wedge resection was performed in 11 cases, left hemi hepatectomy in 2 cases, left lateral sectionectomy in 2 cases, caudate lobectomy in 1 case. The mean operative time was 248.75 minutes. The mean hospital stay was 13.8 days, and there were no post-operative recurrences during the post-operative follow-up period. Conclusion: When performed by expert surgeons in selected patients, laparoscopic liver resection for HCC is a feasible and safe procedure.
송유정(Yu-Jeong Song),정상호(Sang-Ho Jeong),이영준(Young-Joon Lee),박순태(Soon-Tae Park),최상경(Sang-Kyung Choi),홍순찬(Soon-Chan Hong),정은정(Eun-Jung Jung),주영태(Young-tae Joo),정치영(Chi-Young Jeong),하우송(Woo-Song Ha) 대한외과학회 2010 Annals of Surgical Treatment and Research(ASRT) Vol.79 No.5
Purpose: Combined organ resection is a common operation in gastric cancer surgery. The aim of this study is to investigate the risk of combined minor organ resection (GB, gynecologic organ, appendix etc) in gastric cancer surgery. Methods: The clinical data from 673 consecutive patients who underwent gastrectomy for gastric cancer at a single center were retrospectively analyzed. We investigated clinical data between open groups (OG) and laparoscopy groups (LAG), and we divided the patients into 3 groups: no resection group, minor organ resection group and major organ (spleen, pancreas, and colon) resection group. Results: There were higher complication rates in major organ resection group (59.3%, 53.8%) than no resection (32.3%, 19.1%) or minor organ resection groups (38.7%, 20%) both in OG and LAG (P<0.05). However, there were longer hospital stays in minor (22.2 days) and major resection groups (24.1) than no resection group (16.2) in OG, but stays were longer in major resection group (30.9) than minor (14.5) and no resection group (16.2) in LAG (P<0.01). Operative times were longer in minor (287 min) and major organ resection group (310) than no resection group (243) in OG (P<0.00). However, operation time was longer in major resection group (505) than minor (415) and no resection group (370) in LAG (P=0.00). Conclusion: Combined minor organ resection with gastrectomy does not increase morbidity, and there is no statistical difference in hospital stay and op time than no resection group in LAG.
김가정(Ka-Jeong Kim),이영준(Young-Joon Lee),주영태(Young-Tae Ju),정치영(Chi-Young Jeong),정은정(Eun-Jung Jung),홍순찬(Soon-Chan Hong),최상경(Sang-Kyung Choi),하우송(Woo-Song Ha),박순태(Soon-Tae Park) 대한외과학회 2008 Annals of Surgical Treatment and Research(ASRT) Vol.74 No.5
Purpose: Chylous ascites is an accumulation of lymphatic fluid within the peritoneal cavity caused by obstruction or rupture of the peritoneal or retroperitoneal lymphatic drainage system. Postoperative chylous ascites is a rare complication of abdominal surgery. In the present study, we analyzed patients who developed postoperative chylous ascites after gastrectomy. Methods: From February 2003 to June 2006, we treated 7 cases of chylous ascites that occurred after gastrectomy for gastric cancer. We reviewed the medical charts of these patients retrospectively. Results: The incidence of chylous ascites after gastrectomy was 1.7%. Mean triglyceride concentration of the ascitic fluid was 437 ㎎/㎗ (range: 128 ㎎/㎗∼816 ㎎/㎗). Total parenteral nutrition and somatostatin were administered to 6 patients, and 1 patient was treated with oral diuretics and serial paracentesis. Conclusion: The incidence of chylous ascites is low, but may increase with more aggressive surgery. Surgeons should consider chylous ascites if the character of drainage is milky. Conservative management is usually effective for the treatment of postoperative chylous ascites. If conservative management fails, surgical management should be considered.