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조성래,정창곡 동덕여자대학교 2002 생활과학연구 Vol.7 No.-
This study was carried out to evaluate the utility of health interview questionnaire used for workers when they have regular health screening. Data were collected from 1,008 workers (male; 72.82%, female; 27.18%) employed in 6 different industries located in Seoul and Kyounggi area from March 1, 1998 to December 1, 1998. Averarge age of the study population was 31.9 (±6.2)years and age range was 20 to 60 years. Kappa indices were -0.222~0.128 for the items of health recognition and daily life habit and -0.038~0.017 for the items of symptom and sings, negative predictability and positives predictability were 98.52 and 98.5 respectively only for the item on weight change and blood sugar, and there were no items over 60% for both sensitivity and specificity. In conclusion the validity and reliability were very low for the health interview questionnaire and it should be modified to be used for health screening.
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최빈아,정창곡 韓國保健敎育.健康增進學會 2003 보건교육건강증진학회지 Vol.20 No.2
The purpose of this study was to develop game style courseware in oral health instruction for elementary school children. The manufacturing equipment and languages which were used to develop the courseware were : Photoshop version 7.0, Illustrator version 10.0, HTML, Dream Weaver MX, Editplus, CSS and Java - script. The data base was built up by using PHP and mySQL over Internet Explorer version 4.0. The contents of courseware for oral health education were based on the list of oral health affaires of the Department of Health and Welfare, 2002. The story of the game ‘Saving Hayani locked down in a castle of a cavity man’ was developed far the learners to learn oral health by inducing learning motivation. A character named ‘Chani’ was introduced to the learners to be more friendly with the program while they were learning. As the game was made of three step education levels, the learner most pass the prepared test given at each step to advance to a higher level. A database connected to web was constructed to store the scores the learned earned at each step. In conclusion the courseware will help the elementary school children learn oral health care efficiently through the internet regardless of time and space.
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양지열,이옥준,손승명,우창곡,정유숙,양예원,권지현,이기형,한혜숙 대한암학회 2018 Cancer Research and Treatment Vol.50 No.3
Purpose Malignant pleural effusions (MPEs) are often observed in lung cancer, particularly adenocarcinoma. The aim of this study was to investigate epidermal growth factor receptor (EGFR) mutation status in lung adenocarcinoma-associated MPEs (LA-MPEs) and its correlation with efficacy of EGFR tyrosine kinase inhibitor (TKI) therapy. Materials and Methods Samples comprised 40 cell blocks of pathologically-confirmed LA-MPEs collected before the start of EGFR TKI therapy. EGFR mutation status was re-evaluated by peptide nucleic acid clamping and the clinical outcomes of EGFR TKItreated patients were analyzed retrospectively. Results EGFR mutations were detected in 72.5% of LA-MPE cell blocks (29/40). The median progression- free survival for patients with EGFRmutations in LA-MPEs was better than that for patients with wild-type EGFR (7.33 months vs. 2.07 months; hazard ratio, 0.486; 95% confidence interval, 0.206 to 1.144; p=0.032). The objective response rate (ORR) of 26 patients with EGFR mutations in LA-MPEs among the 36 patients with measurable lesions was 80.8%, while the ORR of the 10 patients with wild-type EGFR in LA-MPEs was 10% (p < 0.001). Among the 26 patients with EGFR mutations in LA-MPEs, the ORR of target lesions and LA-MPEs were 88.5% and 61.5%, respectively (p=0.026). Conclusion EGFRmutation status in cell blocks of LA-MPEs confirmed by pathologic diagnosis is highly predictive of EGFR TKI efficacy. For patients with EGFRmutations in LA-MPEs, the response to EGFR TKIs seems to be worse for pleural effusions than for solid tumors.
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